GI Infectious Bacteria Flashcards

1
Q

What is the resevoir of cholera? Transmission?

A

Shellfish; Fecal-oral of contaminated water

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2
Q

What are the symptoms and complications of Cholera?

A

Abrupt onset vomiting and WATERY diarrhea; Dehydration, hypotension and Electrolyte imbalance

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3
Q

What is the affected GI site of cholera? Morphology?

A

Small intestine; No change on biopsy

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4
Q

How is cholera treated?

A

Hydration

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5
Q

Discuss the pathogenesis of cholera infection?

A

Non-invase
AB subunit toxin; B causes direct endocytosis, A is transported to ER, increase in cAMP, open CTFR, Cl- released, SECRETORY diarrhea.

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6
Q

What is the resevoir of Campylobacter jejuni? Transmission?

A

Poultry, sheep, cattle; Fecal-oral

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7
Q

What are the symptoms and complications of C. jejuni?

A

Watery/Bloody diarrhea with or without flu-like prodrome;

If patient is HLA-B27 positive, Arthritis, Guillain-Barre and Erythema nodosum

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8
Q

Affected GI site, Morphology and characteristics of C. jejuni?

A

Colon;
Cryptitis, Crypt absesses, lamnia propia neutrophil infiltrate.
Oxidase positive, microaerophilic

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9
Q

Diagnosis and Treatment of C. jejuni?

A

Stool culture;

Hydration if symptoms last

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10
Q

Discuss the pathogenesis of C. jejuni?

A

Colonization of intestinal mucosa, adherence and entrance into endothelial cells via vacuoles, moves using cell’s microtubule structure.

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11
Q

What is the resevoir and transmission of Shigella?

A

Humans; Fecal-oral.

Potato/Egg salad, lettuce and raw vegetables.

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12
Q

What is the affected GI site and morphology of Shigella?

A

Left colon and ileum.

Non-motile, Hemorrhagic, ulcerated mucosa. Cryptitis, Crypt absesses, lamnia propia neutrophil infiltrate.

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13
Q

What are the symptoms and complications of Shigella?

A

BLOODY diarrhea and fever

If HLA-B27 positive; Reiter syndrome, Hemolytic-uremic syndrome

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14
Q

What is the treatment and diagnosis of shigella?

A

Stool culture;

Antibiotics. Antidiarrheals are CONTRAINDICATED.

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15
Q

Discuss the pathogenesis of Shigella.

A

IpaB inserts into bilayer, IpaC disrupts it, Bacteria multiply and spread via Actin tails in cytoplasm using IcsA,P and VirA, Shigatoxin kills cell.

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