GI Infectious Bacteria Flashcards
What is the resevoir of cholera? Transmission?
Shellfish; Fecal-oral of contaminated water
What are the symptoms and complications of Cholera?
Abrupt onset vomiting and WATERY diarrhea; Dehydration, hypotension and Electrolyte imbalance
What is the affected GI site of cholera? Morphology?
Small intestine; No change on biopsy
How is cholera treated?
Hydration
Discuss the pathogenesis of cholera infection?
Non-invase
AB subunit toxin; B causes direct endocytosis, A is transported to ER, increase in cAMP, open CTFR, Cl- released, SECRETORY diarrhea.
What is the resevoir of Campylobacter jejuni? Transmission?
Poultry, sheep, cattle; Fecal-oral
What are the symptoms and complications of C. jejuni?
Watery/Bloody diarrhea with or without flu-like prodrome;
If patient is HLA-B27 positive, Arthritis, Guillain-Barre and Erythema nodosum
Affected GI site, Morphology and characteristics of C. jejuni?
Colon;
Cryptitis, Crypt absesses, lamnia propia neutrophil infiltrate.
Oxidase positive, microaerophilic
Diagnosis and Treatment of C. jejuni?
Stool culture;
Hydration if symptoms last
Discuss the pathogenesis of C. jejuni?
Colonization of intestinal mucosa, adherence and entrance into endothelial cells via vacuoles, moves using cell’s microtubule structure.
What is the resevoir and transmission of Shigella?
Humans; Fecal-oral.
Potato/Egg salad, lettuce and raw vegetables.
What is the affected GI site and morphology of Shigella?
Left colon and ileum.
Non-motile, Hemorrhagic, ulcerated mucosa. Cryptitis, Crypt absesses, lamnia propia neutrophil infiltrate.
What are the symptoms and complications of Shigella?
BLOODY diarrhea and fever
If HLA-B27 positive; Reiter syndrome, Hemolytic-uremic syndrome
What is the treatment and diagnosis of shigella?
Stool culture;
Antibiotics. Antidiarrheals are CONTRAINDICATED.
Discuss the pathogenesis of Shigella.
IpaB inserts into bilayer, IpaC disrupts it, Bacteria multiply and spread via Actin tails in cytoplasm using IcsA,P and VirA, Shigatoxin kills cell.
