GI Infectious Bacteria Pt 2

Question 1

What is the resevoir and transmission of Salmonella?

Answer 1

Poultry and REPTILES; Fecal-oral or person to person

Question 2

What is the Affected GI site and Morphology of Salmonella?

Answer 2

Colon and Small intestine

Enlarged, soft spleen with pale red pulp, Necrotic parenchyma with macrophages. Produces H2S.

Question 3

What are the symptoms and complications of Salmonella?

Answer 3

First Watery/Bloody diarrhea, then Bacteremia w/ flu-like symptoms. Rose spots on chest/abd
May colonize gb; Sickle cell pts are susceptible to Osteomyelitis.

Question 4

What is the treatment and diagnosis of salmonella?

Answer 4

Diagnosed via stool culture; ABx during bacteremia

Question 5

Discuss the pathogenesis of Salmonella

Answer 5

Endocytosed via M-cell, moves into submucosa, Ingested by M0 in lamina propria, Proliferate in vacuoles, Carried to lymphatics, spleen and liver, LPS in bloodstream causes inflammatory response.

Question 6

What is the resevoir and transmission of Yersinia?

Answer 6

Pigs; Fecal-oral

Question 7

What is the Affected GI site and Morphology of Yersinia?

Answer 7

Ileum, APPENDIX, right colon.
Lymph node and Peyer’s patch hyperplasia, Bowel wall thickening. May see Granulomas (don’t confuse w/ crohns or appendicitis)

Question 8

What are the symptoms and complications of Yersinia?

Answer 8

Pharyngitis, arthralgia, Erythema nodosum, Fever, cramps.

Hemolytic anemia and Hemochromatosis pts at great risk. Sterile arthritis, Reiter syndrome and glomerulonephritis

Question 9

How is Yersinia diagnosed?

Answer 9

Stool/Blood culture

Question 10

Discuss the pathogenesis of Yersinia?

Answer 10

Invade M-cells, Iron uptake system that mediates iron capture and transport is involved. Iron enhances virulence, and stimulates systemic dissemination.

Question 11

What are some symptoms and complications of C. diff?

Answer 11

Hypoalbuminemia, ABx-associated diarrhea +/- blood

Question 12

Morphology and characteristics of C. diff

Answer 12

Exudative plaques, distended crypts with mucopurulent exduate that ‘erupts’ to the surface.
Gram POSITIVE, strict anaerobe, can’t reduce sulfate to sulfite, makes endospores

Question 13

Treatment and diagnosis of C.diff

Answer 13

Diagnosed using C.diff TOXIN.

Discontinue ABx, If severe use Vancomycin or Metronidazole

Question 14

What is the resevoir of Listeria?

Answer 14

Cold processed meats and dairy products

Question 15

What are the symptoms and complications of Listeria?

Answer 15

Fever, myalgia, meningitis, FETAL ABORTION.

Invasive disease in PREGNANT WOMEN and immunocompromised pts