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Microbiology > RNA Viruses > Flashcards

RNA Viruses Flashcards

1
Q

Single-stranded, positive sense, ENVELOPED, icosahedral RNA virus

A 
Flavivirus:
HCV
HGV
West nile
Dengue
Yellow fever

Togavirus:
Rubella

Retrovirus:
HTV
HTLV
Sarcoma

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2
Q

Single-stranded, positive sense, ENVELOPED, helical RNA virus

A

Corona virus

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3
Q

Single-stranded, positive sense, NAKED, icosahedral RNA virus

A

Calici:
Norwalk/Noro
Sapovirus
HEV

Picorna:
Polio
Entero
Echo
Coxackie
Rhino
HAV

Astrovirus

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4
Q

Single-stranded, negative sense, enveloped, HELICAL, RNA virus

A 
Paramyxo:
Mumps
Measles
RSV
Parainfluenza

Filo:
Marburg
Ebola

Orthomyxo:
Influenza

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5
Q

Single-stranded, negative sense, enveloped, BULLET, RNA virus

A

Rhabdo:
Rabies
Vesicular stomatitis

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6
Q

Single-stranded, ambisence and negative sense, enveloped, helical RNA virus

A

Arena:
LCV
Lassa fever

Bunya:
Hantavirus
CCHF
Cali encephalitis

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7
Q

All RNA virus have single-stranded DNA except?

A

Reovirus

Rotavirus

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8
Q

All RNA viruses replicate in the cytoplasm except?

A

Influenza

Retrovirus

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9
Q

MC clinical form of poliomyelitis

A

Abortive poliomyelitis

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10
Q

Cowdry type B intranuclear inclusions

A

Poliovirus

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11
Q

Killed polio vaccine

A

Salk IPV (injection)

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12
Q

Live, attenuated polio vaccine

A

Sabin OPV (oral)

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13
Q

MCC of myocarditis and pericarditis

A

Coxsackie virus

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14
Q

MCC of aseptic meningitis

A

Enteroviruses:
Coxsackie
Polio
Echo

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15
Q

Causes hand, foot, and mouth disease

A

Coxsackie virus

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16
Q

Enteric cytopathic human orphan

A

Echovirus

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17
Q

MCC of common colds

A

Rhinovirus

2nd: Coronavirus

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18
Q

Most frequently infected by Hepa A

A

Children

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19
Q

Most impt test for Hepa A

A

Anti-HAV IgM

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20
Q

Hepa E has high mortality in?

A

Pregnant women

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21
Q

MCC of nonbacterial diarrhea in adults

A

Norwalk/Norovirus

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22
Q

MCC of childhood diarrhea

A

Rotavirus

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23
Q

Type of influenza which causes pandemic

A

Influenza A

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24
Q

Type of influenza which causes major outbreaks of influenza (does not lead to pandemic)

A

Influenza B (only a human virus)

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25
Q

Virulence factor of Influenza virus for binding; it is the target of neutralizing antibody

A

Hemagglutinin

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26
Q

Virulence factor of Influenza virus for entry; cleaves neuraminic acid (sialic acid)

A

Neuraminidase

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27
Q

Causes influenza pandemic

A

Antigenic shift

Influenza A

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28
Q

Causes influenza epidemics

A

Antigenic drifts (Influenza B)

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29
Q

Complications of Influenza virus

A

Staph pneumonia

Reye syndrome

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30
Q

DOC for influenza virus

A

Oseltamivir or Zanamivir

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31
Q

Drug for influenza A only

A

Amantadine or rimantadine (prevents viral uncoating)

32
Q

Symptom unique to influenza

A

Myalgia

33
Q

Damson disease is also called as?

A

Subacute sclerosing panencephalitis (Measles)

34
Q

Associated with type 1 DM

A

Mumps virus

35
Q

Warthin finkeldey giant cells

A

Measles

36
Q

Most important cause of pneumonia and bronchiolitis in infants

A

RSV

37
Q

DOC for RSV infection (viral pneumonia)

A

Ribavirin

38
Q

Steeple sign

A

Croup (Laryngotracheobronchitis)

39
Q

Causes croup

A

Parainfluenza virus 1 and 2

40
Q

DOC for croup

A

Racemic epinephrine

41
Q

Negri bodies

A

Rabies

42
Q

Club-shaped spikes

A

Coronavirus

43
Q

CXR: noncavitary “ground-glass” infiltrates

A

SARS (coronavirus)

44
Q

Atypical pneumonia rapidly progressing to ARDS

A

SARS

45
Q

Most specific test for dengue

A

Dengue PCR

46
Q

Laterality of pleural effusion in dengue

A

Right

47
Q

Criteria for severe dengue

A

Severe plasma leakage

Severe bleeding

Severe organ involvement

48
Q

Warning signs of dengue

A 
Abdominal pain/tenderness
Persistent vomiting
Clinical fluid accumulation
Mucosal bleed
Lethargy, restlessness
Liver enlargement >2cm
Increase in HCT concurrent with rapid decrease in platelet count
49
Q

Most prevalent blood-borne pathogen

A

Hepa C (IV drug abusers)

50
Q

It greatly enhances rate of hepa ca caused by Hepa C

A

Alcoholism

51
Q

Hepa infection with autoimmune reactions (thyroiditis, etc)

A

Hepa C

52
Q

Main cause of essential mixed cryoglobulinemia

A

Hepa C

53
Q

MCC indication for liver transplantation

A

Cirrhosis caused by Hepa C

54
Q

DOC for acute hepa C in children

A

Interferon

55
Q

DOC for chronic hepa C

A

Peginterferon

Ribavirin

56
Q

Prodrome followed by 3-day maculopapular rash and postauricular LAD

A

Rubella

57
Q

5 Bs of congenital rubella syndrome

A 
Bulag- cataracts
Bingi- sensorineural deafness
Bobo- MR
Butas ang puso (PDA)
Blueberry muffin baby
58
Q

RNA dependent DNA polymerase

A

Reverse transcriptase (Retrovirdae)

59
Q

HIV fusion protein

A

GP41

60
Q

HIV attachment protein

A

GP120

61
Q

HIV major capsid protein; impt for dx

A

p24

62
Q

HIV: directs entry of the dsDNA provirus into the nucleus

A

MA (p17)

63
Q

HIV: responsible for rapid antigenic changes

A

gp120

64
Q

Gene responsible for activation of transcription of HIV viral genes

A

Tat gene

65
Q

1 cause of mortality in AIDS

A

Disseminated TB

66
Q

PCP pneumonia in AIDS occurs when CD4 count is?

A
67
Q

TB, esophageal candidiasis, and kaposi sarcoma in AIDS occurs when CD4 count is?

A
68
Q

MC AIDS-defining illness

A

P. carinii pneumonia

69
Q

Used to monitor response and for prognostication in AIDS

A

PCR

70
Q

Highly active antiretroviral therapy (HAART)

A

2 nucleoside inhibitors (zidovudine + lamivudine) + protease inhibitor (indinavir)

71
Q

Malignant T cells with flower-shaped nucleus

A

Adult T cell leukemia

HTLV-associated myelopathy

72
Q

Thread-like viruses; longest viruses

A

Ebola virus (filoviridae)

73
Q

Virus with bird-mosquito-man cycle

A

West nile virus

74
Q

MCC of epidemic encephalitis

A

Japanese B encephalitis

75
Q

Area in the brain affected by Japanese B encephalitis

A

Thalamus (thalamic infarcts)

76
Q

Double-stranded, naked, icosahedral, linear, RNA virus

A

Reovirus:
Rotavirus
Colorado
Tick fever

Microbiology (9 decks)

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