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Microbiology 2 > RNA Viruses > Flashcards

RNA Viruses Flashcards

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0
Q

All RNA viruses replicate in the cytoplasm except the

A

Influenza

Retro

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1
Q

All RNA viruses have a single stranded DNA except

A

Reo

Rota

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2
Q 
RNA viruses
Double stranded
Naked
Icosahedral
Linear
A

Reo

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3
Q

Most common cause of childhood diarrhea

A

Rota

Reo

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4
Q

RNA viruses
Positive sense
Naked
Icosahedral

A

Calici
Picorna
Astro

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5
Q

Caliciviridae

A

Hep E

Norwalk

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6
Q

Hep strain which does not cause liver cirrhosis and cancer

A

Hepatitis E
Expectant mothers
Calici

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7
Q

Most common cause of nonbacterial diarrhea in adults

A

Viral Gastroenteritis
Norwalk virus
Calici

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8
Q

Picornaviridae

A 
PERCHed on a PIC
Polio
Echo
Rhino
Coxsackie
Hep A
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9
Q

Enteroviruses of Picornaviridae

A

Polio
Echo
Coxsackie
- Hep A

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10
Q

Replicates in the anterior horn of the spinal cord causing paralysis

A

Polio

Picorna

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11
Q

Three serologic types of Polio based on _

A

Outer capsid proteins

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12
Q

Most common clinical form of Polio

A

Abortive poliomyelitis

Picorna

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13
Q

Aseptic meningitis caused by Polio

A

Nonparalytic poliomyelitis

Picorna

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14
Q

Flaccid paralysis with permanent motor damage

A

Paralytic poliomyelitis

Picorna

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15
Q

Cowdry type
A
B

A

HSV and ZVZ

Polio

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16
Q

Between the two polio vaccines, which one interrupts transmission and afford secondary protection by spread to others?

A

Live Sabin

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17
Q

Between the two polio vaccines, which one induces intestinal IgA and interferes with virus replication in the gut?

A

Live Sabin

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18
Q

Between the two polio vaccines, which one can revert to virulence and cause disease in the immunocompromised?

A

Live Sabin

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19
Q

Between the two polio vaccines, which one would impair immunization when there is coinfection with other enteroviruses?

A

Live Sabin

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20
Q

Fever, sore throat and tender vesicles in oropharynx

A

Herpangina
Coxsackie A
Picorna

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21
Q

Vesicular rash on hands and feet

Mouth ulcerations

A

Hand foot and mouth disease
Coxsackie
Picorna

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22
Q

Fever and severe pleuritic type pain

A

Pleurodynia
Coxsackie B
Picorna

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23
Q

Most common cause of myocarditis and pericarditis

A

Coxsackie

Picorna

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24
Q

Most common cause of aseptic meningitis

A

Coxsackie A and B

Picorna

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25
Q 
Aseptic meningitis
URTI
Fever and rash
Infantile diarrhea
Hemorrhagic conjunctivitis
A

Enteric Cytopathic Human Orphan
Echovirus
Picorna

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26
Q

Common colds

A

Rhino
Picorna
33C acid labile

Corona

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27
Q

Enterovirus 72

A

Hep A

Picorna

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28
Q

Self limited hepatitis

A

Hep A

Picorna

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29
Q

Most important diagnostic test of Hep A

A

Anti HAV IgM

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30
Q

Raw shellfish

A

Hep A

Picorna

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31
Q 
RNA virus
Single stranded
Positive sense
Enveloped
Helical
A

Corona

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32
Q

Club shaped spikes

A

Corona

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33
Q

Virus binds to _ in the lungs causing atypical pneumonia rapidly progressing to ARDS

A

V3 receptors
SARS
Corona

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34
Q

Non cavitary ground glass infiltrates

A

SARS

Corona

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35
Q

RNA viruses
Positive sense
Enveloped
Icosahedral

A

Flavi
Toga
Retro

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36
Q

Worst DENV serotype

A

DENV2

Flavi

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37
Q

Dengue
Diagnostic test
Vector

A

Dengue IgM
Aedes aegypti

Flavi

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38
Q

Influenzalike syndrome with maculopapular rash and severe pains in muscles and joints

A

Breakbone fever
Dengue
Flavi

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39
Q

Dengue warning signs

A 
Persistent vomiting
Lethargy
Abdominal pain  
Mucosal bleed
Liver >2 cm
Fluid accumulation
Inc HCT with thrombocytopenia
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40
Q

Hypervariable region in glycoprotein envelope

A

Hep C

Flavi

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41
Q

Diagnostic test for Hep C

A

Anti HCV or HCV RNA

PCR

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42
Q

Most prevalent blood borne pathogen

A

Hep C

Flavi

43
Q

IV drug abusers

A

Hep C

Flavi

44
Q

Main cause of essential mixed cryoglobulinemia

A

Hep C

Flavi

45
Q

DOC for Hep C
Acute
Chronic

A

Interferon

Peginterferon Ribavirin

46
Q

Most common indication for liver transplantation

A

Hep C

Flavi

47
Q

Prodrome followed by 3 day maculopapular rash and posterior auricular LAD

A

German Measles
Rubella
Toga

48
Q 
PDA
Congenital cataracts
Sensorineural deafness
MR
Blueberry muffin baby
1st trimester
A

Bulag bingi bobo butas ang puso blueberry
Congenital rubella syndrome
Rubella
Toga

49
Q

HIV
Transmembrane or fusion protein
Surface protein for attachment

A

gp41

gp120

50
Q

HIV

Major capsid protein

A

CA or p24

51
Q

HIV
Direct entry to nucleus
Viral assembly

A

MA or p17

52
Q

HIV

Nucleocapsid

A

NC or p7

53
Q

HIV genes

A

Gag
Pol
Env

54
Q

HIV genes

Gag codes for

A

P24 and p7 NC

P17 matrix

55
Q

HIV genes

Pol codes for

A

Reverse transcriptase
Protease
Integrase

56
Q

HIV genes

Env codes for

A

Gp120

Gp41

57
Q

HIV protein

Antigenicity changes rapidly

A

Gp120

58
Q

Serologic markers for infection in HIV

A

Anti- p24

59
Q

Most immunogenic region of gp120

A

V3

60
Q

Stages of HIV infection

A 
0 infection
1 window period
2 seroconversion viral load, + HIV test
3 latent CD4 goes down
4 early symptomatic CD4 500-200 5 years 
5 AIDS CD4<200 2 years
61
Q

Definitive diagnosis for HIV

A

Western blot analysis

62
Q

HIV treatment

A

Highly active antiretroviral therapy (HAART)

63
Q

HAART is composed of

A

2 nucleoside inhibitors - zidovudine and lamivudine

Protease inhibitor - indinavir

64
Q

HIV+

HBV, HCV, MAC/MAI

A

Immune reconstitution syndrome

65
Q 
RNA virus
Single stranded
Negative sense
Enveloped
Helical
A

Paramyxo
Filo ebola
Orthomyxo

66
Q

Major antigens of influenza

A

Hemagglutinin

Neuraminidase

67
Q

Influenza
A
B
C

A

Pandemics
Outbreaks
Mild respiratory tract infection

68
Q

Binds to the cell surface receptor

Target of neutralizing antibody

A

Hemagglutinin

Influenza A - 16

69
Q

Cleaves neuraminic acid to release progeny virus

Degrades protective mucus layer in respiratory tract

A

Neuraminidase

Influenza A - 9

70
Q

T or F
Influenza B virus is only a human virus
Influenza B has no antigens in common with influenza A

A

T

T

71
Q

Sudden major changes based genomic reassortment leading to pandemics

A

Antigenic shift

72
Q

Slow progressive minor pchanges based on mutations in the genome RNA leading to epidemics

A

Antigenic drifts

73
Q

DOC for Influenza

A

Oseltamivir or Zanamivir

74
Q

DOC for Influenza A

A

Amantidine or rimantidine

75
Q

Paramyxoviridae

A

Parainfluenza
RSV
Measles
Mumps

76
Q

Hemagglutinin +
Neuraminidase +
Fusion protein +

A

Parainfluenza
Mumps
Paramyxo

77
Q

Hemagglutinin +
Neuramidase -
Fusion protein +

A

Measles

Paramyxo

78
Q

Hemagglutinin -
Neuraminidase -
Fusion protein +

A

RSV

Paramyxo

79
Q

Warthin Finkeldey cells

A

Measles

Paramyxo

80
Q

Vasculitic rash

A

Measles

Paramyxo

81
Q

Koplik’s spot enanthem

A

Measles

Paramyxo

82
Q

Nagayama enanthen

A

Roseola

83
Q

Forch Heimer enanthem

A

Rubella

84
Q

Cough
Coryza
Conjunctivitis

A

Measles

Paramyxo

85
Q

Damson disease

A

SSPE
Measles
Paramyxo

86
Q

Tender swelling of the parotid glands which increase in pain when drinking citrus juices

A

Mumps

Paramyxo

87
Q

Parotitis
Orchitis
Meningitis septic

A

Mumps

Paramyxo

88
Q

Most important cause of pneumonia and bronchilitis in infants

A

Viral pneumonia
RSV
Paramyxo

89
Q

DOC for RSV

A

Rivabirine

90
Q

Stipple sign

A

Laryngotracheobronchitis or croup
Parainfluenza 1 and 2
Paramyxo

91
Q

RNA virus
Negative sense
Enveloped
Linear

A

Rhabdo

92
Q

Bullet shaped enveloped virus which moves by axonal transport to CNS

A

Rabies

Rhabdo

93
Q

Negri bodies

A

Rabies

Rhabdo

94
Q

Pre exposure to rabies

A

Vaccine

95
Q

Post rabies exposure with intact skin

A

No treatment

96
Q

Post rabies exposure with minor scratches or abrasion

A

Vaccine

97
Q

Post rabies exposure to transdermal bites or scratches, contamination with mucous membrane, and exposure to bat bites

A

Vaccine and Ig

98
Q

Only vaccine used postexposure

A

Rabies

99
Q

Malignant T cells with FLOWER shaped nucleus

Adult T cell leukemia and myelopathy

A

HTLV

100
Q

Long threadlike viruses

A

Ebola

Filo

101
Q

Most common cause of epidemic encephalitis prevalent in SEA

A

Japanese B encephalitis

Flavi

102
Q

Thalamic infarcts

Temporal lobe infarcts

A

Japanese B encephalitis

Herpes

103
Q

Aedes

Culex

A

Dengue

Japanese B virus

104
Q

Post transfusion hepatitis

A

Hep C

Microbiology 2 (13 decks)

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