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Microbiology 2 > RNA Viruses > Flashcards

RNA Viruses Flashcards

0
Q

All RNA viruses replicate in the cytoplasm except the

A

Influenza

Retro

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1
Q

All RNA viruses have a single stranded DNA except

A

Reo

Rota

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2
Q 
RNA viruses
Double stranded
Naked
Icosahedral
Linear
A

Reo

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3
Q

Most common cause of childhood diarrhea

A

Rota

Reo

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4
Q

RNA viruses
Positive sense
Naked
Icosahedral

A

Calici
Picorna
Astro

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5
Q

Caliciviridae

A

Hep E

Norwalk

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6
Q

Hep strain which does not cause liver cirrhosis and cancer

A

Hepatitis E
Expectant mothers
Calici

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7
Q

Most common cause of nonbacterial diarrhea in adults

A

Viral Gastroenteritis
Norwalk virus
Calici

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8
Q

Picornaviridae

A 
PERCHed on a PIC
Polio
Echo
Rhino
Coxsackie
Hep A
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9
Q

Enteroviruses of Picornaviridae

A

Polio
Echo
Coxsackie
- Hep A

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10
Q

Replicates in the anterior horn of the spinal cord causing paralysis

A

Polio

Picorna

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11
Q

Three serologic types of Polio based on _

A

Outer capsid proteins

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12
Q

Most common clinical form of Polio

A

Abortive poliomyelitis

Picorna

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13
Q

Aseptic meningitis caused by Polio

A

Nonparalytic poliomyelitis

Picorna

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14
Q

Flaccid paralysis with permanent motor damage

A

Paralytic poliomyelitis

Picorna

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15
Q

Cowdry type
A
B

A

HSV and ZVZ

Polio

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16
Q

Between the two polio vaccines, which one interrupts transmission and afford secondary protection by spread to others?

A

Live Sabin

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17
Q

Between the two polio vaccines, which one induces intestinal IgA and interferes with virus replication in the gut?

A

Live Sabin

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18
Q

Between the two polio vaccines, which one can revert to virulence and cause disease in the immunocompromised?

A

Live Sabin

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19
Q

Between the two polio vaccines, which one would impair immunization when there is coinfection with other enteroviruses?

A

Live Sabin

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20
Q

Fever, sore throat and tender vesicles in oropharynx

A

Herpangina
Coxsackie A
Picorna

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21
Q

Vesicular rash on hands and feet

Mouth ulcerations

A

Hand foot and mouth disease
Coxsackie
Picorna

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22
Q

Fever and severe pleuritic type pain

A

Pleurodynia
Coxsackie B
Picorna

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23
Q

Most common cause of myocarditis and pericarditis

A

Coxsackie

Picorna

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24
Most common cause of aseptic meningitis
Coxsackie A and B | Picorna
25
``` Aseptic meningitis URTI Fever and rash Infantile diarrhea Hemorrhagic conjunctivitis ```
Enteric Cytopathic Human Orphan Echovirus Picorna
26
Common colds
Rhino Picorna 33C acid labile Corona
27
Enterovirus 72
Hep A | Picorna
28
Self limited hepatitis
Hep A | Picorna
29
Most important diagnostic test of Hep A
Anti HAV IgM
30
Raw shellfish
Hep A | Picorna
31
``` RNA virus Single stranded Positive sense Enveloped Helical ```
Corona
32
Club shaped spikes
Corona
33
Virus binds to _ in the lungs causing atypical pneumonia rapidly progressing to ARDS
V3 receptors SARS Corona
34
Non cavitary ground glass infiltrates
SARS | Corona
35
RNA viruses Positive sense Enveloped Icosahedral
Flavi Toga Retro
36
Worst DENV serotype
DENV2 | Flavi
37
Dengue Diagnostic test Vector
Dengue IgM Aedes aegypti Flavi
38
Influenzalike syndrome with maculopapular rash and severe pains in muscles and joints
Breakbone fever Dengue Flavi
39
Dengue warning signs
``` Persistent vomiting Lethargy Abdominal pain Mucosal bleed Liver >2 cm Fluid accumulation Inc HCT with thrombocytopenia ```
40
Hypervariable region in glycoprotein envelope
Hep C | Flavi
41
Diagnostic test for Hep C
Anti HCV or HCV RNA | PCR
42
Most prevalent blood borne pathogen
Hep C | Flavi
43
IV drug abusers
Hep C | Flavi
44
Main cause of essential mixed cryoglobulinemia
Hep C | Flavi
45
DOC for Hep C Acute Chronic
Interferon | Peginterferon Ribavirin
46
Most common indication for liver transplantation
Hep C | Flavi
47
Prodrome followed by 3 day maculopapular rash and posterior auricular LAD
German Measles Rubella Toga
48
``` PDA Congenital cataracts Sensorineural deafness MR Blueberry muffin baby 1st trimester ```
Bulag bingi bobo butas ang puso blueberry Congenital rubella syndrome Rubella Toga
49
HIV Transmembrane or fusion protein Surface protein for attachment
gp41 | gp120
50
HIV | Major capsid protein
CA or p24
51
HIV Direct entry to nucleus Viral assembly
MA or p17
52
HIV | Nucleocapsid
NC or p7
53
HIV genes
Gag Pol Env
54
HIV genes | Gag codes for
P24 and p7 NC | P17 matrix
55
HIV genes | Pol codes for
Reverse transcriptase Protease Integrase
56
HIV genes | Env codes for
Gp120 | Gp41
57
HIV protein | Antigenicity changes rapidly
Gp120
58
Serologic markers for infection in HIV
Anti- p24
59
Most immunogenic region of gp120
V3
60
Stages of HIV infection
``` 0 infection 1 window period 2 seroconversion viral load, + HIV test 3 latent CD4 goes down 4 early symptomatic CD4 500-200 5 years 5 AIDS CD4<200 2 years ```
61
Definitive diagnosis for HIV
Western blot analysis
62
HIV treatment
Highly active antiretroviral therapy (HAART)
63
HAART is composed of
2 nucleoside inhibitors - zidovudine and lamivudine | Protease inhibitor - indinavir
64
HIV+ | HBV, HCV, MAC/MAI
Immune reconstitution syndrome
65
``` RNA virus Single stranded Negative sense Enveloped Helical ```
Paramyxo Filo ebola Orthomyxo
66
Major antigens of influenza
Hemagglutinin | Neuraminidase
67
Influenza A B C
Pandemics Outbreaks Mild respiratory tract infection
68
Binds to the cell surface receptor | Target of neutralizing antibody
Hemagglutinin | Influenza A - 16
69
Cleaves neuraminic acid to release progeny virus | Degrades protective mucus layer in respiratory tract
Neuraminidase | Influenza A - 9
70
T or F Influenza B virus is only a human virus Influenza B has no antigens in common with influenza A
T | T
71
Sudden major changes based genomic reassortment leading to pandemics
Antigenic shift
72
Slow progressive minor pchanges based on mutations in the genome RNA leading to epidemics
Antigenic drifts
73
DOC for Influenza
Oseltamivir or Zanamivir
74
DOC for Influenza A
Amantidine or rimantidine
75
Paramyxoviridae
Parainfluenza RSV Measles Mumps
76
Hemagglutinin + Neuraminidase + Fusion protein +
Parainfluenza Mumps Paramyxo
77
Hemagglutinin + Neuramidase - Fusion protein +
Measles | Paramyxo
78
Hemagglutinin - Neuraminidase - Fusion protein +
RSV | Paramyxo
79
Warthin Finkeldey cells
Measles | Paramyxo
80
Vasculitic rash
Measles | Paramyxo
81
Koplik's spot enanthem
Measles | Paramyxo
82
Nagayama enanthen
Roseola
83
Forch Heimer enanthem
Rubella
84
Cough Coryza Conjunctivitis
Measles | Paramyxo
85
Damson disease
SSPE Measles Paramyxo
86
Tender swelling of the parotid glands which increase in pain when drinking citrus juices
Mumps | Paramyxo
87
Parotitis Orchitis Meningitis septic
Mumps | Paramyxo
88
Most important cause of pneumonia and bronchilitis in infants
Viral pneumonia RSV Paramyxo
89
DOC for RSV
Rivabirine
90
Stipple sign
Laryngotracheobronchitis or croup Parainfluenza 1 and 2 Paramyxo
91
RNA virus Negative sense Enveloped Linear
Rhabdo
92
Bullet shaped enveloped virus which moves by axonal transport to CNS
Rabies | Rhabdo
93
Negri bodies
Rabies | Rhabdo
94
Pre exposure to rabies
Vaccine
95
Post rabies exposure with intact skin
No treatment
96
Post rabies exposure with minor scratches or abrasion
Vaccine
97
Post rabies exposure to transdermal bites or scratches, contamination with mucous membrane, and exposure to bat bites
Vaccine and Ig
98
Only vaccine used postexposure
Rabies
99
Malignant T cells with FLOWER shaped nucleus | Adult T cell leukemia and myelopathy
HTLV
100
Long threadlike viruses
Ebola | Filo
101
Most common cause of epidemic encephalitis prevalent in SEA
Japanese B encephalitis | Flavi
102
Thalamic infarcts | Temporal lobe infarcts
Japanese B encephalitis | Herpes
103
Aedes | Culex
Dengue | Japanese B virus
104
Post transfusion hepatitis
Hep C

Microbiology 2 (13 decks)

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