Risk assessment Flashcards
What is the definition of Risk Assessment?
Process in which the hazard and risks of negative effects on humans
and/or the environment as a result of exposure to substances are
evaluated
What is a hazard?
something that has the potential to cause unwanted consequences
What is a risk?
the chance that undesirable consequences will occur
How is risk calculated?
Risk = hazard x exposure
What is researched with a hazard assessment?
Has the compound the potency to
cause an adverse effect?
What is researched with a Dosis-effect assessment?
What is the relationship between
the dose and manifestation of
the effect in humans?
What 3 assessment does risk assessment consist of?
Hazard assessment
Dosis-effect assesment
exposure assessment
What does risk characterisation determine?
The estimated
occurrence of a
negative effect in a
given population
What aspects determine experience of risks?
-risk of health damage
-consequences of health damage
-voluntary exposure
-attention in media
-trust in responsible authorities
What is LD50?
Dose at which 50% lethality occurs
(=acute toxicity value)
What are the 2 classification types of substances?
- non-genotoxic substances = threshold
-genotoxic carcinogens = non-threshold
What are steps to derive a standard for threshold?
- Toxicity tests
- Point of Departure (PoD)
- Establish critical effect
- From PoD to standard
What is the purpose of a chronic test?
estimate NOAEL
What is TDI?
Tolerable Daily Intake
- unavoidable compounds
What is ADI?
Acceptable Daily Intake
- avoidable compounds
