ADME Flashcards
What is absorption?
the
substance enters the
body
What is distribution?
the
substance moves
from the site of entry
to other areas of the
body.
What is biotransformation?
the body changes the
substance into new
chemicals
(metabolites)
What is excretion?
the
substance or its
metabolites leave the
body
Why is ADME important? (4)
-Determines the concentration of a compound in the body
-determines Bioavailability
-development of drug, food product
-assessing toxic effects
What are the ADME compartments?
Absorption: intestines, skin, lungs
Distribution: from blood to organs
Elimination: feces, urine, air
What are the ADME compartments macro and micro?
macro: lungs, intestines, kidneys
micro: cells, organells
What are type of membranes?
connective tissues
cell membranes
organel membranes
What is the general structure of membranes?
dubbele fosfolipide laag
cholesterol
glycoprotein
channel proteins
Wat is het verschil tussen cis en trans vetzuren?
cis = waterstoffen naast elkaar
trans = waterstoffen kruislings van elkaar
Wat is het verschil tussen verzadigde en onverzadigde vetzuren?
verzadigde = zonder dubbele binding. vast bij kamertemp
onverzadigde = met dubbele binding. vloeibaar bij kamertemp
onverzadigd = beter
What is passive transport?
-gaat met de concentratiegradient mee
hangt af van:
-ionisatiegraad
-ph
-oplosbaarheid water
-oplosbaarheid vet
-grootte vd molecuul
What are influential factors of passive transport?
-ionisatiegraad
-ph
-oplosbaarheid water
-oplosbaarheid vet
-grootte vd molecuul
What does de partition coeffecient tell you?
Ratio of the concentrations of a substance in 2 immiscible solvents
fat soluble or water soluble
Partition coëfficiënt
High P =
Low P =
high P = easily through membranes
low p = better through pores
