Rickettsiae/Endothelial Infections Flashcards
disease caused by rickettsia ricketsii
rocky mt spotted fever
type of microbe for rickettsia, vector?
obligate intracellular G- bacteria, coccobacilli, tick borne
how do rickettsiae parasitize hosts
energy parasites, use host carbon and ATP
how do rickettsiae spread? why is this way helpful?
use host actin for motility and cell invasion, can go from cell to cell w/o encountering host defenses or blood-borne drugs
pathophys of rickettsiae infection
target endothelial cells, alter membranes of these cells which starts cascade leading to DIC, can cause blood to leak out of vessels and lead to shock
clinical presentation of rickettsiae
prodromal: chills, fever, rash (erythematous, maculopapular, petechial) on extremities and trunk
causes vasculitis and is fatal 25% w/o Tx
first line of tx for rickettsia
doxycycline- should be used right away when RMSF suspected, effective when w/i first 5 days of Sx
hantavirus transmission
robovirus (from rodents) and no arthropod vector, usually from inhalation of rodent feces or urine
structure of hanta virus
enveloped RNA viurs w/ segmented genome
seroprevalence of hantavirus
low! means not many antibodies in population and fewer asymptomatic cases
hantavirus patho
viral replication in capillary endothelial cells increases vascular permeability, symptoms caused by this effect and immune responses
esp affects cardiac, pulm and renal systems
geography of hantavirus
also called sin nobre virus, american southwest
CMV connection to endothelia
infects and persists in endothelial cells as well, can be disseminated when replicate in these cells
HHV-8 affect on endothelium
connected to kapsosi’s sarcoma-endothelial neoplasm
infection of endothelium causes angiogenesis
