Ribosomal Antibiotics Flashcards
Ribosomal Antibiotics
SAT C MLS L
Sprectinomycin
Aminoglycosides
Tetracyclines
Chloramphenocol
Macrolides
Lincomides
Stregogramins
Linezolid
Spectinomycin- MOA
binds to 30s subunit and prevents the formation of the initation complex
Spectinomycin- MOR
- Change in Binding Site
- Produce innactivating enzyme
Spectinomycin- admin
Parenteral
Spectinomycin- t 1/2
1-2 hours, 50 hrs in kidney failure
Spectinomycin- Use
- Single Dose Antibiotic tx for Gonorhea when resistant organisms are present and want to use a parenteral form
Aminoglycosides- MOA
Binds to 30s subunit –>
- inhibits 70s formation
- inhibits polyribosome formation
- misreading mRNA
Amigoclycosides- MOR
- Group transferases which innactivate the drug- Amino acetyl/aldenyl/Phospho- trasferases
- Normal inhibitory mechs
Aminoglycosides- Transport into cells
- passive diffusion through porins
- active transport across the cell membrane via O2 DEPENDENT MECHANISM, with energy from the E/C gradient, coupled to a protein pump
Therefore it only works on aerobes and is better with a cell wall destroying agent ie beta lactams
Aminoglycosides- AE
- Neprhotoxic
- Ototoxic- cochlear and vestibular
- Neurotoxic
What organ failure requires dose change of aminoglycosides
Renal
Aminoglycosides wide or narrow therapeutic range?
Narrow
Aminoglycosides- how is it dosed, what properties of aminoglycosides allow it to be dosed that way
dosed once a day for 3 reasons
- concentration dependent killing
- long post antibiotic effect
- nephrotoxicity is based on amount of time it spends at the trough, longer trough= more nephrotox, as does any dec RBF or underlying renal failure
Aminoglycosides- spectrum
Gram negative aerobes
- PSEUDOMONAS
- E.Coli
- Proteus
- klebsiella
- Enterobacter
- Serratia
Aminoglycosides- ROA
IV
Aminoglycosides- excretion
renal
Aminoglycosides- Drugs
- Streptomycin
- Gentomycin
- Tobramycin
- Neomycin
- Actinomycin
- Netilmicin