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Antibiotics- protein synthesis inhibitors Flashcards

1
Q

Macrolides- MOA

A

bind to 50s subunit and prevent translocation

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2
Q

Macrolides- P/O bioavailability

A

good oral bioavailability

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3
Q

Erythromycin- excretion

A

biliary

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4
Q

Clarithromycin- excretion

A

metabolism and renal clearance

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5
Q

Azithromycin- how long does it last, where does it stay, elimination

A

accumulates in tissues and has renal elimination

t1/2 >3 days

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6
Q

Azithromycin- use

A

singe dose for NGU
H. influenza
Moraxella

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7
Q

Macrolides- clinical uses

A 
Gram + cocci- not MRSA
Mycoplasma
chlamydia
ureaplasma
Legionella
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8
Q

Clarithromycin- use

A

H. Pylori

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9
Q

Erythromycin- toxicities

A

GI distress, cholestasis

CI in pregnancy

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10
Q

Erythromycin and Clarithromycin- AE

A

CYP 450 inhibitors –> enhance:

Carbamazepime, theophylline, warfarin

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11
Q

Spectinomycin use

A

Single dose tx for uncomplicated gonorrhea

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12
Q

Aminoglycoside- spectrum

A

Aerobic Gram - rod

Pseudomonas

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13
Q

Streptomycin- Use

A

2nd line for drug resistant Tb

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14
Q

Neomycin- use

A

dec gut flora bfr GI surgery

TOpical

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15
Q

Gentamicin/ Tobramycin- use

A

serious G- rods

synergy with aminoglycosides

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16
Q

Amikacin- use

A

less susceptible to innactivation enzymes

17
Q

Tetracycline- Spectrum

A

Staph/ Strep
enterics
anaerobes

18
Q

Tetracyclines- Use

A

Chlamydia, PID
Rickettsia
Mycoplasma pneumonia
Lyme dz

19
Q

Tigecycline- spectrum

20
Q

Chloramphenicol- spectrum

A

Gram+ Strep
Gram - except pseudomonas
anaerobes

21
Q

Chloramplhenicol- use

A

Meningitis
Brain abscess
topical eye infection

22
Q

Macrolides- spectrum

A

G+
Straph/strep
anaerobes
Atypical infections- chlamydia, corynobacterium diptheria, b. pertussis, C. Jejuni

23
Q

Macrolides- Use

A

Pt allergic to Penicillin

Atypicals

24
Q

Clarithromycin- Use

A

Respiratory infections especially Mycobacterium

25
Q

Azithromycin- use

A

Single dose chlamydia
H. Flu
Moraxella

26
Q

Telithromycin- use

A

Community RTI

27
Q

Telithromycin- spectrum

A

Pneumonia
E. Faecalis
S. Aureus

28
Q

Lincosamides- spectrum

A

Anaerobes = BACTEROIDES
Starph, strrep
G- anaerobes

29
Q

Lincosamides- use

A

Acne
anaerobic abscess
Staph osteomyelitis

30
Q

Mupirosin- use

A

topical staph/ strep

nasal application for s. aureus

31
Q

Linezolid- spectrum

Pharm main (26 decks)

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