Antiretrovirals Flashcards
NRTI’s
Zidovudine, Zalcitabine, Diadanosine, Stavudine, Abacavir, tenofovir, Lamivudien, emcitabine
NRTI’s MOA
substrate for RT, lack 3’OH group can’t elongate RNA
NRTI’s- what cells does it work in
Newly infected cells
NRTI- HIV1, 2 or both
Both
What is given to mother to prevent spread of HIV during child birth
NRIT
NRTI- AE
Lactic Acidosis (mtDNA interference), hepatic steatosis, N/V/D, fatigue, insomnia drugs with a d cause reversible, dose dependent peripheral neuropath
Zidovudine- abrev
AZT
Zidovudine- AE
Bone marrow suppression, malaise, myopathies, N/V, HA
Zidovudine- Contraindications
Don’t give to people with Ganciclovir, used to tx CMV
Zalcitabine- abrev
ddC
Zalcitabine- AE
peripheral neuropathy, pancreatitis
Didanosine- Abrev
ddl
Didanosine- AE
Pancreatitis- deadly Peripheral neuritis is common
Didanosine- meals
Do not take with meals, acid will destroy the drug
Stavudine- Abrev
d4t
Stavudine- AE
lipodystrophy- prevrent with pravastatin and atrovastatin peripheral nueropathy
Abacavir- abrev
ABC
Abacavir- AE
hypersensitivity rxn- deadly
Tenofovir- AE
nephrotoxic
Lamivudine, emtricitabine- AE
minimal toxicity, GI, HA
Emtricitabine- abrev
FTC
NRTI- MOR
3-4 AA mutations
NNRTI’s
Nevirapine, delavirdine, enfavirenz, etravirine, rilpirivine
NNRTI- MOA
non competitive antagonist of RT
NNRTI- new or old cells?
New
NNRTI- HIV1, 2, or both
HIV 1