Rheumatology Short Flashcards
Pattern of joint involvement in RA?
symmetrical deforming small joint polyarthritis sparing DIPs
Extra articular signs of psoriatic arthritis?
psoriatic rash dactylitis enthesitis nail pitting, ridging, onycholysis aortic regurgitation apical lung fibrosis conjunctivitis/uveitis
Risk factors for destructive disease in RA?
high titre RF or positive anti CCP constitutional symptoms erosions early on XR rheumatoid nodules early HLA-DR4
Causes of early onset osteoarthritis?
trauma juvenile arthritis haemochromatosis acromegaly charcot's joint
Antibodies associated with SLE?
anti dsDNA
anti-Sm
ANA
Antibodies associated with systemic sclerosis?
Anti-Scl-70
Antibodies associated with limited sclerosis?
anti-centromere
Antibodies associated with scleroderma renal crisis?
anti-RNA polymerase III
Extra articular manifestations of ankylosing spondylitis (6 As)?
apical lung fibrosis AR anterior uveitis achilles tendonitis (enthesitis) atlanto-axial subluxation amyloidosis (+ IBD)
What joint deformities may be present in RA?
swan neck deformity boutonniere deformity ulnar deviation of MCP radial deviation of wrist joint z deformity of thumb volar (anteior) subluxation of the fingers - towards palm
Findings on hand examination in scleroderma?
sclerodactyly calcinosis raynaud's digital ulceration telangectasia
Extra articular manifestations of RA?
eye disease - episcleritis/scleritis anaemia ILD pleural effusions pericardial effusions pyoderma gangrenosum splenomegaly mononeuritis multiplex
What are the possible causes of anaemia in a patient with RA?
anaemia of chronic disease GI blood loss due to NSAIDs folate deficiency due to methotrexate pernicious anaemia bone marrow suppression due to methotrexate felty's syndrome autoimmune haemolytic anaemia
What are the 5 different patterns of joint involvement in psoriatic arthritis?
assymmetrical oligoarthritis involving mainly DIPs
symmetrical polyarthritis sparing DIPs (RA pattern)
DIP arthritis
arthritis mutilans
spondyloarthritis
Which biologics are used for the management of psoriatic arthritis?
anti-TNF
anti-IL17
anti-IL23/23
JAK inhibitor