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Rizk Review > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Pattern of AM stiffness in OA?

A

Lasts < 30 minutes

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2
Q

2 XR findings for OA?

A

Osteophytes, Joint narrowing

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3
Q

Pattern of arthritis in Hereditary Hemochromatosis?

A

2nd + 3rd MCP joint

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4
Q

XR appearance of arthritis in Hereditary Hemochromatosis?

A

Hook-shaped osteophytes

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5
Q

Best initial treatment for OA?

A

Scheduled acetaminophen

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6
Q

Only role for corticosteroids in setting of OA?

A

Intra-articular injection … (never systemic)

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7
Q

Pattern of AM stiffness in RA?

A

Lasts > 45 minutes

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8
Q

Patient with HX of RA presents with swelling in popliteal fossa – diagnosis?

A

Baker cyst

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9
Q

Diagnostic test for Baker cyst?

A

Need to distinguish from popliteal artery aneurysm … US

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10
Q

Extra-articular manifestations of RA are more common in patients with high titers of …

A

RF

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11
Q

What treatment typically worsens RA nodules?

A

Methotrexate

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12
Q

2 characteristics of RA pleural effusion?

A

High LDH, Low glucose (< 30)

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13
Q

Are RA pleural effusions exudative or transudative?

A

Exudative

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14
Q

Ocular manifestation of RA?

A

Episcleritis

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15
Q

Triad of clinical symptoms seen in Felty Syndrome?

A

RA, Splenomegaly, Neutropenia

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16
Q

3 aspects of treatment for Felty Syndrome?

A

Methotrexate, Corticosteroids, Splenectomy

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17
Q

56 yo female with HX of RA develops R knee pain; PE shows fever, R knee redness/swelling – diagnosis?

A

Septic arthritis

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18
Q

First step in management of Septic arthritis?

A

Joint aspiration

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19
Q

What is the only medication that slows the progression of joint destruction in RA?

A

DMARDs … Methotrexate

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20
Q

AE of sulfasalazine?

A

Reversible oligospermia

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21
Q

Major AE of hydroxyurea?

A

Retinopathy

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22
Q

Monthly monitoring required for patients on hydroxyurea?

A

Ophthalmology visits

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23
Q

AE of D-penicillinamine?

A

Bronchiolitis obliterans PNA

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24
Q

3 conditions that contraindicate methotrexate use?

A

Renal disease, ETOH abuse, Liver failure

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25
Q

Medication that is contraindicated with methotrexate use?

A

TMP-SMX

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26
Q

Which cytokine is a significant mediator of inflammation in RA?

A

TNFa

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27
Q

6 aspects of clinical presentation for Adult Still’s Disease?

A

Fever, Arthritis, Rash during febrile episodes, Sore throat, LAD, Splenomegaly

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28
Q

Characteristic lab finding in setting of Adult Still’s Disease?

A

Increased ferritin

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29
Q

Most common cause of death in Ehlers-Danlos Syndrome?

A

Aortic aneurysm rupture

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30
Q

Malignancy associated with Sjogren Syndrome?

A

Lymphoma

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31
Q

Diagnostic test for Sjogren Syndrome?

A

Lip biopsy of minor salivary glands

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32
Q

Appearance of biopsy in Sjogren Syndrome?

A

T lymphocyte infiltration

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33
Q

DOC for Raynaud’s phenomenon in Systemic sclerosis?

A

CCBs

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34
Q

Most common cause of death in Systemic sclerosis?

A

Pulmonary HTN

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35
Q

What accounts for development of pulmonary HTN in Systemic sclerosis?

A

Intimal proliferation

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36
Q

Patient with PMHX of scleroderma is diagnosed with acute renal failure, severe HTN, edema – diagnosis?

A

Scleroderma renal crisis

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37
Q

Best treatment for Scleroderma renal crisis?

A

ACEIs

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38
Q

Change to GI that is pathognomonic for scleroderma?

A

Wide-mouth diverticula

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39
Q

Best treatment for SIBO?

A

10 days of ciprofloxacin

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40
Q

What is most specific skin finding for dermatomyositis?

A

Grotton papules

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41
Q

Characteristic of Grotton papules?

A

Spares the interdigital spaces

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42
Q

Lab value that is always seen in Polymyalgia Rheumatica?

A

ESR > 50

43
Q

Best test for establishing diagnosis of ankylosing spondylitis?

A

Pelvic XR

44
Q

2 aspects of clinical presentation for ankylosing spondylitis?

A

Iritis, Sacroilitis

45
Q

Heart murmur associated with ankylosing spondylitis?

A

AR

46
Q

Best treatment for ankylosing spondylitis?

A

Anti-TNFa

47
Q

Patient develops painful keratotic papules + plaques of soles, penis; Reports recent HX of urethritis, arthritis – diagnosis?

A

Reiter’s Syndrome

48
Q

Most common pathogen responsible for Reiter’s Syndrome?

A

Chlamydia

49
Q

3 DOC for psoriatic arthritis?

A

Anti-TNFa, Methotrexate, NSAIDs

50
Q

MSK disorder associated with Crohn’s Disease?

A

SI joint arthritis

51
Q

Location of pathogen in joint in reactive arthritis?

A

Aseptic effusion … No growth of pathogen in joint

52
Q

Location of pathogen in joint in Whipple’s Disease?

A

Synovial tissues

53
Q

What is required for definitive diagnosis of gout?

A

Aspiration of fluid

54
Q

DOC for overproduction of uric acid causing gout?

A

Allopurinol

55
Q

DOC for underexcretion of uric acid causing gout?

A

Probenecid

56
Q

2 conditions associated with Pseudogout?

A

Hyperparathyroidism, Hemochromatosis

57
Q

Which joint is most affected by Pseudogout?

A

Knee

58
Q

XR appearance seen in setting of Pseudogout?

A

Chondrocalcinosis

59
Q

Description of chondrocalcinosis seen in Pseudogout XR?

A

Linear calcification of joint cartilage

60
Q

Best treatment for Pseudogout?

A

NSAIDs, Intra-articular corticosteroids

61
Q

Most SN lab for SLE?

A

ANA

62
Q

Most SP lab for SLE?

A

Anti-dsDNA

63
Q

Antibody associated with Mixed Connective Tissue Disease?

A

Anti-U1-RNP

64
Q

Which lab finding is most characteristic of Anti-Phospholipid Syndrome?

A

Prolonged PTT

65
Q

Which antibody is needed on ELISA for diagnosis of Anti-Phospholipid Syndrome?

A

Anti-Cardiolipin Antibody

66
Q

Characteristic of rash in vasculitis?

A

Palpable

67
Q

2 examples of large-vessel vasculitis?

A

Takayasu arteritis, Giant cell arteritis

68
Q

Change to vision in Giant cell arteritis?

A

Amaurosis fugax … transient loss of vision

69
Q

Clinical presentation of Takayasu arteritis?

A

Raynaud’s phenomenon

70
Q

Which vessels are most affected in Takayasu arteritis?

A

Aortic arch vessels

71
Q

2 DOC for treatment of Takayasu arteritis?

A

Glucocorticoids, CCBs

72
Q

1 example of medium-vessel vasculitis?

A

Polyarteritis nodosum

73
Q

Pathogen associated with Polyarteritis nodosum?

A

Hepatitis B

74
Q

Which organ system is always spared in Polyarteritis nodosum?

A

Lungs

75
Q

Most common site of aneurysm in Polyarteritis nodosum?

A

SMA

76
Q

Is P-ANCA or C-ANCA (+) in Polyarteritis nodosum?

A

Both are (-)

77
Q

3 examples of small-vessel vasculitis?

A

Microscopic polyarteritis, Wegner’s granulomatosis, Churg-Strauss disease

78
Q

Is P-ANCA or C-ANCA (+) in Microscopic polyarteritis?

A

P-ANCA

79
Q

Renal manifestation of Microscopic polyarteritis?

A

Rapidly Progressive GN

80
Q

Is P-ANCA or C-ANCA (+) in Churg-Strauss disease?

A

P-ANCA

81
Q

Hallmark lab test seen in Churg-Strauss disease?

A

Eosinophilia

82
Q

Clinical presentation of Churg-Strauss disease?

A

Adult-onset asthma

83
Q

Is P-ANCA or C-ANCA (+) in Wegner’s granulomatosis?

A

C-ANCA

84
Q

Alternate name for Wegner’s granulomatosis?

A

Granulomatosis with polyangiitis

85
Q

Which 3 organ systems are most affected by Wegner’s granulomatosis?

A

Sinuses, Lungs, Kidneys

86
Q

2 DOC for treatment of Wegner’s granulomatosis?

A

Corticosteroids, Cyclophosphamide

87
Q

Pathogen associated with cryoglobulinemia?

A

Hepatitis C

88
Q

Which PE finding will differentiate Rotator Cuff Tendinitis from Rotator Cuff Tear?

A

Tear = (+) drop arm test

89
Q

Which 2 motions are limited by Biceps tendinitis?

A

Elbow flexion, Supination

90
Q

3 aspects of treatment for De Quervain’s Tenosynovitis?

A

Spica splint, Steroid injection, NSAIDs

91
Q

Which 2 tendons are affected by De Quervain’s Tenosynovitis?

A

EBP + APL

92
Q

Best diagnostic test for Carpal Tunnel Syndrome?

A

EMG

93
Q

Best initial treatment for Carpal Tunnel Syndrome?

A

Immobilization

94
Q

Patient presents with clenched fist; Recently punched someone in mouth – pathogen responsible for symptoms?

A

Staph, Eikenella

95
Q

Patient presents with clenched fist; Recently punched someone in mouth – best treatment?

A

Ampicillin-Sulbactam

96
Q

Best treatment for plantar fasciitis?

A

Stretching

97
Q

Patient presents with pain to upper medial aspect of tibia that increases with climbing stairs – diagnosis?

A

Anserine bursitis

98
Q

2 aspects of treatment for Anserine bursitis?

A

Steroid injection, Quadriceps training

99
Q

Best test for diagnosis of avascular necrosis?

A

MRI

100
Q

Best treatment for trochanteric bursitis?

A

Stretching, Steroid injection

101
Q

Best treatment for lumbar strain?

A

Exercise therapy, NSAIDs

102
Q

MRI appearance of spinal stenosis?

A
103
Q

3 conditions associated with Cauda Equina Syndrome?

A

Paget Disease, Ankylosing spondylitis, Tumors

Rizk Review (19 decks)

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