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Rizk Review > Hematologic Malignancy > Flashcards

Hematologic Malignancy Flashcards

1
Q

Best diagnostic test for Hodgkin Lymphoma?

A

Lymph node excisional biopsy

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2
Q

Stage I Hodgkin Lymphoma?

A

One LN region

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3
Q

Stage II Hodgkin Lymphoma?

A

2+ LN regions on 1 side of diaphragm

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4
Q

Stage III Hodgkin Lymphoma?

A

2+ LN regions on both sides of diaphragm

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5
Q

Stage IV Hodgkin Lymphoma?

A

Extranodal sites

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6
Q

Best treatment for Stage I + II Hodgkin Lymphoma?

A

ABVD chemotherapy, then XRT

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7
Q

Best treatment for Stage III + IV Hodgkin Lymphoma?

A

ABVD chemotherapy

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8
Q

Best management for female who undergoes CTX + XRT for Hodgkin Lymphoma?

A

Begin mammogram screening earlier … Due to increased risk of secondary breast CA

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9
Q

Exposure that increases risk of Non-Hodgkin Lymphoma?

A

CXT + XRT treatment of Hodgkin Lymphoma

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10
Q

Virus associated with Non-Hodgkin Lymphoma?

A

HTLV1

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11
Q

Best treatment for low-grade Non-Hodgkin Lymphoma?

A

Observation

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12
Q

Best treatment for high-grade Non-Hodgkin Lymphoma?

A

R-CHOP chemotherapy

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13
Q

Plasma cell % that diagnoses Multiple Myeloma?

A

> 10%

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14
Q

M protein spike that diagnoses Multiple Myeloma?

A

> 3 mg/dL

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15
Q

Precursor to Multiple Myeloma?

A

MGUS … Monoclonal Gammopathy of Undetermined Significance

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16
Q

Best treatment for MGUS?

A

None

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17
Q

Appearance of Multiple Myeloma on XR?

A

Lytic lesions

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18
Q

Imaging study of choice for Multiple Myeloma?

A

XR (skeletal survey) … bone scan won’t show lytic lesions

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19
Q

Patient with Multiple Myeloma develops acute back pain with neurologic symptoms – diagnosis?

A

Cord compression

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20
Q

Patient with Multiple Myeloma develops acute back pain with neurologic symptoms – diagnosis?

A

Start corticosteroids, Order MRI, XRT + neurosurgery consult

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21
Q

Clinical presentation of Waldenstrom Macroglobulinemia?

A

Hyperviscosity Syndrome … blurry vision, HA, dizziness

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22
Q

Best treatment for Waldenstrom Macroglobulinemia?

A

Plasmapheresis

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23
Q

Myelodysplastic syndrome chromosome with best prognosis?

A

5q deletion

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24
Q

Appearance of Pseudo-Pelger-Huet Syndrome on blood smear?

A

Bilobed nuclei

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25
Q

Most common cause of death in AML?

A

Infection

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26
Q

DOC for patients with Myelodysplastic syndrome with 5q deletion?

A

Lenalidomide

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27
Q

4 myeloproliferative syndromes?

A

CML, Polycythemia vera, Idiopathic myelofibrosis, essential thrombocytopenia

28
Q

Complication of 4 myeloproliferative syndromes?

A

AML

29
Q

Change to LAP in 4 myeloproliferative syndromes?

A

Low … LAP = marker of cell maturity

30
Q

Consequence of t(9;22) mutation in CML?

A

Increased tyrosine kinase activity

31
Q

Change to EPO level in polycythemia vera?

A

Decreased

32
Q

3 treatments of choice for polycythemia vera?

A

ASA, Phlebotomy, Hydroxyurea

33
Q

Change to EPO level in secondary polycythemia?

A

Increased

34
Q

2 aspects of clinical presentation of Idiopathic myelofibrosis?

A

Splenomegaly, anemia

35
Q

Appearance of blood smear in Idiopathic myelofibrosis?

A

Tear-shaped RBCs

36
Q

What accounts for Tear-shaped RBCs in Idiopathic myelofibrosis?

A

Bone marrow fibrosis

37
Q

Clinical presentation of Essential Thrombosis?

A

Thrombosis + Hemorrhage

38
Q

What accounts for Thrombosis in Essential Thrombosis?

A

Excessive platelet count

39
Q

What accounts for Hemorrhage in Essential Thrombosis?

A

Defective platelet function

40
Q

DOC for Essential Thrombosis?

A

Hydroxyurea

41
Q

Lab finding seen in AML?

A

Pancytopenia

42
Q

Genetic mutation responsible for AML?

A

t(15;17)

43
Q

Best treatment for AML?

A

ATRA … (all trans retinoic acid)

44
Q

Appearance of AML on blood smear?

A

Blasts with Auer rods

45
Q

Complication of AML?

A

DIC

46
Q

What accounts for development of DIC in AML?

A

Cytoplasmic granules in malignant cells release procoagulant

47
Q

Composition of Auer rods in AML?

A

Lysosomes

48
Q

Treatment that is protective against renal failure in tumor lysis syndrome?

A

Allopurinol

49
Q

What accounts for appearance of mediastinal mass in ALL?

A

T cell invasion of thymus

50
Q

CD___ indicates favorable prognosis in ALL?

A

CD10

51
Q

Poor prognostic factor in ALL?

A

t(9;22) … unlike BCR-ABL being a good prognostic factor in CML

52
Q

Best stain for blasts in ALL?

A

TdT

53
Q

AE of vinblastine?

A

Bone marrow suppression

54
Q

AE of vincristine?

A

Peripheral toxicity

55
Q

DOC for treatment of CML?

A

Imatinib

56
Q

MOA of Imatinib in treatment of CML?

A

Inhibition of tyrosine kinase

57
Q

65 yo male presents for abnormal labs; HGB = 12, WBC = 66,000 with 96% small lymphocytes, PL = 120; PE shows no LAD, no splenomegaly – diagnosis

A

CLL

58
Q

65 yo male presents for abnormal labs; HGB = 12, WBC = 66,000 with 96% small lymphocytes, PL = 120; PE shows no LAD, no splenomegaly – treatment of choice?

A

Observation

59
Q

CD factors that are (+) in CLL?

A

CD5, CD23

60
Q

Clinical presentation of CLL?

A

Typically asymptomatic … but also Widespread LN enlargement

61
Q

AE of Fludarabine (used to treat CLL)?

A

Leukopenia

62
Q

NML prophylaxis for Pneumocystis jiroveci?

A

TMP-SMX

63
Q

If patient is allergic to sulfa, what is alternate prophylaxis for Pneumocystis jiroveci?

A

Dapsone

64
Q

Which test needs to be performed prior to giving patient prophylactic dapsone?

A

G6PD test

65
Q

2 aspects of clinical presentation for Hairy Cell Leukemia?

A

Pancytopenia, Splenomegaly

66
Q

Specific staining for Hairy Cell Leukemia?

A

TRAP

67
Q

DOC for treatment of Hairy Cell Leukemia?

A

2-CDA

Rizk Review (19 decks)

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