Dermatology Flashcards
DOC for urticaria?
Diphenhydramine
MOA of Diphenhydramine?
H1 receptor blocker
DOC for urticaria that is refractory to Diphenhydramine?
Add famotidine
MOA of famotidine?
H2 blocker
3 conditions that might be responsible for prolonged urticaria?
Hepatitis C, Lymphoproliferative disorder, Parasitic infection
Next step of workup for prolonged urticaria?
ESR + CRP; Skin biopsy
3 pathogens that may be responsible for prolonged urticaria?
H. pylori (related to Campylobacter), Strongyloidiasis, Fliariasis
Children presents with genital edema after riding bicycle – diagnosis?
Hereditary angioedema
3 labs to check in setting of hereditary angioedema?
C2, C4, C1 esterase inhibitor
Change to C2, C4, C1 esterase inhibitor in hereditary angioedema?
Low
Change to C2, C4, C1 esterase inhibitor in acquired angioedema?
NML
3 treatment options for acquired angioedema?
Epinephrine, Antihistamines, Corticosteroids
Which medication is NOT effective in treatment of hereditary angioedema?
Epinephrine
2 options for acute treatment of hereditary angioedema?
C1 inhibitor concentrate, FFP
Long term prophylaxis for hereditary angioedema?
Danazol
MOA of Danazol?
Modified testosterone
MOA of Danazol in prophylaxis for hereditary angioedema?
Increased C1 inhibitor production in liver
AE of Danazol?
Hiruisitism
Etiology of urticaria?
Allergy with associated HSN reaction
Etiology of dermatitis?
Inflammatory reaction
Triad of symptoms seen in setting of Atopic Dermatitis?
Atopic dermatitis, Asthma, Hay fever
DOC for Atopic Dermatitis?
1% topical hydrocortisone
DOC for refractory cases of Atopic Dermatitis?
Tacrolimus
Example of Contact dermatitis?
Poison ivy/oak
Contact dermatitis represents a Type ___ HSN reaction
4
DOC for Contact dermatitis?
Topical corticosteroid (ointment, not cream)
DOC for Nummular dermatitis?
Bath oils, topical steroids
Young male presents with seborrheic dermatitis that is difficult to treat – what is next test to order?
HIV testing
Pathogen associated with seborrheic dermatitis?
Malassezia
3 DOCs for treatment of seborrheic dermatitis?
Selenium sulfide, ketoconazole, topical steroids
What can distinguish SLE from seborrheic dermatitis?
SLE = spares the nasolabial fold; Seborrheic dermatitis = involves the nasolabial fold
Leser-Trelat sign involves multiple crops of …
Seborrheic keratosis
Leser-Trelat sign suggests …
Gastric carcinoma
2 nail changes seen in setting of psoriasis?
Nail pitting, Onycholysis
___ Sign refers to scraping of psoriasis spots, resulting in bleeding
Auspitz
Which medication by exacerbate psoriasis flairs?
Lithium … (think of bipolar patient)
39 yo female presents with psoriatic rash after streptococcal pharyngitis – diagnosis?
Guttate psoriasis
4 pathogens that may result in Guttate psoriasis?
Staph, Candida, HPV, HIV
Classic description of Guttate psoriasis?
Drop-shaped lesions
3 treatments for Guttate psoriasis?
Treat underlying infection, UV-B light, Topical corticosteroids
Why is Erythrodermic psoriasis considered to be a dermatologic emergency?
Electrolyte imbalance, dehydration
DOC for psoriasis?
High potency TOPICAL (not systemic!) steroids … NOT over-the-counter (low-dose)
4 conditions associated with Porphyria Cutanea Tarda?
ETOH use, Hepatitis C, Estrogen therapy, Hemochromatosis
First step of workup for Porphyria Cutanea Tarda?
24-hour urine porphyrin studies
Target morphology rash that results after taking TMP-SMX for UTI?
Erythema multiforme
2 pathogens associated with Erythema multiforme?
HSV, Mycoplasma pneumoniae
3 drugs associated with Erythema multiforme?
Sulfonamides, Barbiturates, Phenytoin
Toxic Epidermal Necrolysis (TEN) involves ___% of body surface area
>10-20
3 conditions associated with Erythema Nodosum?
Sarcoidosis, IBD, Behcet’s Disease
2 medications associated with Erythema Nodosum?
Sulfonamides, OCPs
3 pathogens associated with Erythema Nodosum?
Histoplasmosis, Coccidiosis, Strep pharyngitis
Antibodies seen in setting of bullous pemphigoid?
IgG directed against hemidesmosomes
Clinical presentation of bullous pemphigoid?
Tense blisters
Are mucous membranes involved in bullous pemphigoid?
No
Best treatment for bullous pemphigoid?
Corticosteroids
Antibodies seen in setting of pemphigus vulgaris?
Desmosome proteins
Clinical presentation of pemphigus vulgaris?
Loose blisters that rupture easily
___ Sign refers to blister rupture in pemphigus vulgaris with slight lateral shearing
Nikolsky
Are mucous membranes involved in pemphigus vulgaris?
Yes
Best treatment for pemphigus vulgaris?
High dose corticosteroids
First step of workup of cellulitis?
Evaluate for MRSA
Outpatient treatment for cellulitis with MRSA involvement?
TMP-SMX, clindamycin, doxycycline
First step of workup of necrotizing fasciitis?
Immediate CT/MRI; Surgical debridement
Best treatment for non-inflammatory acne with comedones?
Topical retinoid + Benzyl peroxide
Best treatment for inflammatory acne with pustular or nodular appearance?
Topical ABX, then oral ABX
ABX of choice for inflammatory acne?
Doxycycline
Best treatment for severe nodular acne?
Oral isotretinoin
What is needed before beginning patient on Oral isotretinoin?
2 methods of contraception
Patient presents with papules, pustules, cysts, and nodules that appear similarly to acne, but without comedones – diagnosis?
Rosacea
Treatment for Rosacea?
Topical metronidazole
___ refers to Rosacea that involves the nose
Rhinophyma
Oral ABX used for treatment of refractory Rosacea?
Tetracycline, Doxycycline
Alternate name for Tinea versicolor?
Pityriasis
Pathogen responsible for Tinea versicolor?
Malassezia furfur
Appearance of Malassezia furfur on culture?
Spaghetti + Meatballs
Etiology of Malassezia furfur fungemia in infants?
IV lipid nutrition
Pathogen responsible for Tinea Capitis?
Trichophyton microsporum
Relationship of Tinea Capitis to hair?
Invasion of hair shaft
Pathogen responsible for Tinea Barbae?
Trichophyton verrucosum
Pathogen responsible for Tinea Corporis?
Tinea rubrum
Clinical presentation of Tinea Corporis?
Annular lesions
Pathogen responsible for Tinea Cruris?
Tinea rubrum
Pathogen responsible for Tinea Pedis?
Tinea rubrum
Treat all fungal infections with ___, except for …
Topical antifungal agents; Onychomycosis, tinea capitis
Example of topical antifungal agent used to treat all fungal infections, except onychomycosis and tinea capitis?
Imidazole
Treatment for Onychomycosis?
Oral terbinafine
Treatment for recurrent tinea versicolor?
Single-dose ketoconazole, fluconazole
Alternate name for verruca vulgaris?
Warts
Pathogen responsible for verruca vulgaris?
HPV
Treatment for verruca vulgaris?
Cryotherapy
Treatment for refractory verruca vulgaris?
Salicylic acid … (except on face)
Pathogen responsible for condyloma accuminatum?
HPV 6/11
Which strains of HPV cause cervical CA?
HPV 16-18-31-33
Pathogen responsible for Molluscum Contagiosum?
Poxvirus
Next step of workup for child who presents with genital Molluscum Contagiosum?
Suspect sexual abuse … (human is only reservoir)
Pattern of itching seen in Scabies?
Worse at night
Classic skin region that is affected by Scabies?
Finger webs
Treatment for Scabies?
Permethrin, Lindane
Treatment for refractory Scabies?
Ivermectin
CI to oral Ivermectin?
Children, pregnancy
Complication of actinic keratosis?
Squamous cell carcinoma
Treatment for actinic keratosis?
Topical 5-FU (many lesions), Cryotherapy (2-3 lesions)
Indication for systemic 5-FU?
Colon CA treatment
Most common type of skin CA?
Basal Cell Carcinoma
Description of Basal Cell Carcinoma?
Rolled borders
What types of skin CA are associated with Xeroderma pigmentosa?
Squamous cell, Basal cell, Melanoma
Best treatment for Basal Cell Carcinoma?
Excision
Risk factor for Squamous cell carcinoma?
Immunosuppression, Organ transplant
Most significant risk factor for Squamous cell carcinoma?
UV exposure
Most common type of melanoma?
Superficial spreading
Type of melanoma with worst prognosis?
Nodular
Unique characteristic of acral lentiginous melanoma?
Not related to sun exposure
When should you perform sentinel LN biopsy in melaoma?
Lesion > 1 mm
Best treatment for patient with melanoma lesion > 4mm with (+) LN?
Interferon

2 conditions associated with Acanthosis Nigricans?
Metabolic syndrome, Gastric CA
Is albinism inherited or acquired?
Inherited
Etiology of albinism?
Inability of melanocytes to form melanin due to defects in tyrosinase enzyme
Treatment for albinism?
Sun protection
Is vitiligo inherited or acquired?
Acquired
Etiology of vitiligo?
Autoimmune loss of melanocytes
Treatment for vitiligo?
Topical corticosteroids
Complication of vitiligo and albinism?
Increased risk of actinic keratosis + skin CA
47 yo female presents with enlarged tongue, weight loss, peripheral neuropathy, purpura – diagnosis?
Amyloidosis
Characteristic purpura seen in setting of amyloidosis?
“Pinch Purpura” over eyelids