Dermatology Flashcards
DOC for urticaria?
Diphenhydramine
MOA of Diphenhydramine?
H1 receptor blocker
DOC for urticaria that is refractory to Diphenhydramine?
Add famotidine
MOA of famotidine?
H2 blocker
3 conditions that might be responsible for prolonged urticaria?
Hepatitis C, Lymphoproliferative disorder, Parasitic infection
Next step of workup for prolonged urticaria?
ESR + CRP; Skin biopsy
3 pathogens that may be responsible for prolonged urticaria?
H. pylori (related to Campylobacter), Strongyloidiasis, Fliariasis
Children presents with genital edema after riding bicycle – diagnosis?
Hereditary angioedema
3 labs to check in setting of hereditary angioedema?
C2, C4, C1 esterase inhibitor
Change to C2, C4, C1 esterase inhibitor in hereditary angioedema?
Low
Change to C2, C4, C1 esterase inhibitor in acquired angioedema?
NML
3 treatment options for acquired angioedema?
Epinephrine, Antihistamines, Corticosteroids
Which medication is NOT effective in treatment of hereditary angioedema?
Epinephrine
2 options for acute treatment of hereditary angioedema?
C1 inhibitor concentrate, FFP
Long term prophylaxis for hereditary angioedema?
Danazol
MOA of Danazol?
Modified testosterone
MOA of Danazol in prophylaxis for hereditary angioedema?
Increased C1 inhibitor production in liver
AE of Danazol?
Hiruisitism
Etiology of urticaria?
Allergy with associated HSN reaction
Etiology of dermatitis?
Inflammatory reaction
Triad of symptoms seen in setting of Atopic Dermatitis?
Atopic dermatitis, Asthma, Hay fever
DOC for Atopic Dermatitis?
1% topical hydrocortisone
DOC for refractory cases of Atopic Dermatitis?
Tacrolimus
Example of Contact dermatitis?
Poison ivy/oak
Contact dermatitis represents a Type ___ HSN reaction
4
DOC for Contact dermatitis?
Topical corticosteroid (ointment, not cream)
DOC for Nummular dermatitis?
Bath oils, topical steroids
Young male presents with seborrheic dermatitis that is difficult to treat – what is next test to order?
HIV testing
Pathogen associated with seborrheic dermatitis?
Malassezia
3 DOCs for treatment of seborrheic dermatitis?
Selenium sulfide, ketoconazole, topical steroids
What can distinguish SLE from seborrheic dermatitis?
SLE = spares the nasolabial fold; Seborrheic dermatitis = involves the nasolabial fold
Leser-Trelat sign involves multiple crops of …
Seborrheic keratosis
Leser-Trelat sign suggests …
Gastric carcinoma
2 nail changes seen in setting of psoriasis?
Nail pitting, Onycholysis
___ Sign refers to scraping of psoriasis spots, resulting in bleeding
Auspitz
Which medication by exacerbate psoriasis flairs?
Lithium … (think of bipolar patient)
39 yo female presents with psoriatic rash after streptococcal pharyngitis – diagnosis?
Guttate psoriasis
4 pathogens that may result in Guttate psoriasis?
Staph, Candida, HPV, HIV
Classic description of Guttate psoriasis?
Drop-shaped lesions
3 treatments for Guttate psoriasis?
Treat underlying infection, UV-B light, Topical corticosteroids
Why is Erythrodermic psoriasis considered to be a dermatologic emergency?
Electrolyte imbalance, dehydration
DOC for psoriasis?
High potency TOPICAL (not systemic!) steroids … NOT over-the-counter (low-dose)
4 conditions associated with Porphyria Cutanea Tarda?
ETOH use, Hepatitis C, Estrogen therapy, Hemochromatosis
First step of workup for Porphyria Cutanea Tarda?
24-hour urine porphyrin studies
Target morphology rash that results after taking TMP-SMX for UTI?
Erythema multiforme
2 pathogens associated with Erythema multiforme?
HSV, Mycoplasma pneumoniae
3 drugs associated with Erythema multiforme?
Sulfonamides, Barbiturates, Phenytoin
Toxic Epidermal Necrolysis (TEN) involves ___% of body surface area
>10-20
3 conditions associated with Erythema Nodosum?
Sarcoidosis, IBD, Behcet’s Disease