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MCCEE > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Investigations in SLE that specific

A

AntiCCP

Anti SM

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2
Q

Clinical signs of SLE

A

MD SOAP BRAIN

Malar Rash 
Discoid Rash 
Serositis 
Oral ulcer
ANA +ve 
Photosensitivity 
Blood (haemolytic anaemia, thrombocytopenia)
Renal (red cell casts, proteinuria)
Arthritis  
Immune deficient (leukopenia)
Neurological (headache, seizure, neuropathy)
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3
Q

Treatment of SLE

A

Goals

  • early treatment
  • avoid steroids long term
  • monitor follow up

Derm
Sunscreen , ravoid UV light, estrogen

MSK
Vitamin D
Antiinflammatories
hydroxychloroquine to control long term control and prevent flares

Severe disease

  • High dose Pred IV
  • steroid sparing azathioprine, mtx
  • IV cyclophosphamide
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4
Q

Diagnosis of SLE

A

7 clinical features

4 investigations

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5
Q

What is scleroderma?

A

Small vessel vasculopathy

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6
Q

Syndrome associated with scleroderma?

A

CREST

Calcinosis 
Raynaud 
Esophageal dysmotility 
Sclerodactyly 
Telangectasia
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7
Q

Investigations to diagnose scleroderma

A

Anti centromere
Anti topiramase
Anti Scl-70

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8
Q

Management of scleroderma

A 
Derm - steroids topical 
Vascular - vasodilators (CCB)
GI - GERD PPI 
Renal - ACE 
Lungs - interstitial disease cyclophosphamide 
Heart - csc 
Arthritis - , NSAIDS
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9
Q

What is antiphospholipid Ab?

A

Ab interfere with normal coagulation

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10
Q

Investigations to diagnose Antiphospholipid Ab?

A

Anti cardiolipin
ANA positive
Anti beta glycoproteins

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11
Q

Symptoms of antiphospholipid ab syndrome ?

A

Vascular thrombosis
- TIA, multi infarct dementia,
Recurrent spontaneous abortions

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12
Q

Management of antiphospholipid ab syndrome?

A

Lifelong anticoagulant

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13
Q

Investigations to diagnose Sjogrens disease?

A

Anti-SSA/Ro
Anti SSB/La
ANA

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14
Q

Name of the complex involved in Sjogrens?

A

Sicca complex

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15
Q

What is sicca complex?

A

Dry eyes

Dry mouth

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16
Q

What sort of vasculitis is GCA?

A

Large vessel vasculitis

17
Q

Treatment

A
  1. CSC 4 weeks
  2. then tapering regimen
  3. Methylpred if vision loss
18
Q

Prognosis of GCA?

A

Increased risk thoracic aneurysm and aortic dissection

19
Q

Medications that precipitate Gout?

A

FACT

Frusemide
Aspirin low dose / alcohol
Cytotoxic
Thiazide

20
Q

Acute treatment of gout?

A

NSAID
CSC
Colchicine if within 12 hours of onset of sx

21
Q

What is the treatment of pseudo gout?

A

NSAIDS

22
Q

Treatment of pulmonary HTN in scleroderma?

A

Bosetan
Epoprostenol
PE5 inhibitors

23
Q

Difference between diffuse and limited systemic Scleroderma?

A

Limited: skin face hand neck, pulmonary HTN, CREST

Diffuse: widespread, more organ involvement

24
Q

What is pseudo gout associated with?

A 
Haemochromatosis 
Hyopthyroidism 
Hypophosphataemia 
DM 
Hypomagnesaemia 
HyperPTH

MCCEE (16 decks)

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