Rheumatology Flashcards
tx for Lower back pain from lubosacral strain
NSAIDs
when do you do a MRI for back pain?
Positive SLR + low back pain + sensory deficits
*no sensory deficits = no MRI
back pain + super high ESR + fever + point tenderness dx?
S. aureus cord abscess
back pain, bowel/bladder dysfunction, bilateral leg weakness and saddle anesthesia. dx? tx?
cauda equina sy.
tx: steroids + surgical decompresssion
tx of Sciatica?
NSAIDs > stretches > steroids
Felty Syndrome
RA + Splenomegaly + neutropenia
Caplan Syndrome
RA + Pneumoconiosis + lung nodules
MCC of death in ppl with RA?
CAD
if your gonna operate on someone with RA what must you do first? why?
cervical XR looking for C1/C2 subluxation
Rheumatoid Arthritis(RA) dx criteria
4+ of the following:
- morning stiffness lasting >1hr
- wrist and finger involvement(MCP, PIP)
- swelling of at least 3 joints
- symmetric involvement
- rheumatoid nodules
- XR abnormalities showing erosions
- +RF (70% specific) or + anti-CCP(>80% sen. 95% specific)
- CRP or ESR elevation
anemia in RA? why?
anemia of chronic dz, normal MCV
whats special about RA pleural effusions?
lowest glucose levels of all causes
tx of RA
NSAIDs + DMARD(methotrexate > infliximab > hydroxychloroquine(check eyes often))
Seronegative Spondyloarthropathies
what are they? why they called that?
PAIR = Psoriatic Arthritis, Ankylosing Spondyylitis, Idiopathic Juvenile RA, Reactive Arthritis
*called that bc negative Rheumatoid factor
what are all the Seronegative Spondyloarthropathies assocaited wiht…
negative RF, usually involve the spine, sacroiliac joint involvement, HLA B27, Uveitis
Ankylosing Spondylitis
sx? tx?
young male <40, spin or back stiffness worse at night, relieved by leaning forward +/- arthritis, bamboo spine, uveitis(30%), restrictive lung dz(2-15% due to spinal shit)
*tx w/NSAIDs + exercise
Reactive Arthritis
sx?tx?
cant see cant pee cant climb a tree!
* urethrits, GI infection, fever, weight loss, fatigue, arthritis, conjunctivitis,
tx: NSAIDs
Psoriatic Arthritis
sx? tx?
nail pitting, DIP involvment = pencil in cup, sausage-shaped digits, enthesis(inflammation @ tendon insertion sites)
tx: NSAIDs > methotrexate
Idiopathic Juvenile Rheumatoid Arthritis(JRA)
sx? tx?
> 6wks joint pain, fever(>104), salmon-colored rash, polyarthritis, lymphadenopathy, myalgias, splenmegaly, pericardial effusions, high ferritin, anemia of chronic dz, elevated WBC, negative RF & ANA
tx: NSAIDs > steroids
kid with JRA what must you do for him?
EYE EXAM EVERY YEAR TO LOOK FOR UVEITIS
whipple dz
sx? tx?
whipple dz
Dude with joint pains, diarrhea, fat malabsorption, weight loss, bowel bx shows PAS + shit.
tx: TMP/SMX
Osteoarthritis(OA)
sx?
morning stiffness <30 min, crepitus, DIPS involved, Heberdens nodes(DIPS), Bouchards(PIPs)
OA dx?
Xray joint + low leukocytes <2k
tx of OA
acetaminophen
Rotator cuff tear/tendonitis/frozen sx
tear = weakness tendonitis = pain on abduction and external rotation + pt tenderness frozen = ^ + decreased ROM
patellofemoral Syndrome
sx? tx?
imbalance of quads strength or menisal tear. due to trauma = pain in front of knee behind patell when walking up or down stairs, crepitis, joint locking, worse after moveing from sitting for awhile
tx: PT
Systemic Lupus Erythematousus(SLE)
dx criteria?
4 of:
- Skin: malar rash, photosensitivity, Oral ulcers, discoid rash
- Arthralgias
- blood: leukopenia, thrombocytopenia, hemolysis
- Renal: benign proteinuria to ESRD(membranous GN)
- cerebral: behavior change, stroke, seizure, meningitis
- Serositis: pericarditis, pleuritc chest pain, pulmonary HTN, Pneumonia, myocarditis
- Serology: ANA(95% sen), DS-DNA(60% sen but more specific 70%)
How can you differentiate a SLE flare vs another illness like pneumonia?
complement levels drop(C3) and Anti-ds DNA rises in flares
Antiphospholipid syndrome
PTT & PT
elevated PTT, normal PT and normal INR
antiphospholipid syndrome mixing studies
- mixing with APL = no change in PTT; if due to factor deficiency it would return to normal.
- Russel Vipor Venom Test(RVVT) - prolonged and doesnt correct with mixing
tx of antiphosphoplipid syndrome?
heparin then warfarin
Sjogren’s Syndrome
sx?
ab to lacrimal glands and salivary glands +/- vasculitis, lung dz, pancreatitis, RTA, dysparenia(pain w/intercourse)
*dry eyes, drye mouth, sand under eyes and dental carries
Sjogren Syndrome
dx?
- Schirmer test = paper to eye to show decreased wetting
- lip bx
- ANA +, RF +
tx of Sjogren syndrome?
moisturizers, Pilocarpine for eyes & Cevimeline = increases the rate of saliva production
ab positive with systemic scleroderma?
anti-topoisomerase = Scl-70
ab positive in CREST scleroderma?
anti-centromere ab
CREST Scleroderma
Calcinosis of fingers, Raynauds, Esophageal Dysmotitlity, Sclerodactyly, Telangiectasia
Eosinophilic Fasciitis
sx? tx?
inflammation of the fasia under the skin = thick skin taht can look like scleroderma + “orange peel” appearance. will see EOSINOPHILIA(not seen in scleroderm)
- worse with excise
tx: steroids
whats the same between polymyositis and dermatomyositis?
both: proximal M weakness(difficulty rising from chair) & muslce inflmmation(pain + tenderness)
dermato: DERM SHIT! = Gottrons papules(scales over fingers), Heliotrope rash, Shawl Sign(shoulder and neck erythema)
dx & Tx of poly/dermatomyositis?
elevated CPK, elevated aldolase, abnormal electromyogram(EMG)
tx: steroids
anti Jo-1 is associated with…
poly/dermatomyositis + increased risk of intersitial lung dz with both these
what will labs look like in fibro?
all normal!
sx of fibromyalgia?
muscle aches and stiffness with trigger points/point tenderness on palpation and nonrefreshing sleep
*depression and anxiety are common
tx of fibro
exercise > SSRI, TCA(amitriptyline)
Polymyalgia Rheumatic(PMR)
> 50 yoa profound pain and stiffness on the proximal muscles such as shoulders and pelvic girdle. worse in teh mroning and is localized to the muscles rather than to the joints + associated with GCTA
Common lab finding with all vasculitisissss
normocytic anemai = chronic dz, elevated ESR, thrombocytosis
Polyarteritis Nodosa(PAN) sx? tx?
fatigue, malaise, weight loss, feer, skin lesions = purpura rash, joint pain, neuropathy(mononeuritis multiplex)
+ abdomainl pain(worse with eatting), renal involvement, testicular involvment, pericarditis, HTN, lower extremeity ulcers
tx: prednisone + cyclophosphamide
common findings with all vasculitis
list some commonvasculitis
fatigue, malaise, weight loss, feer, skin lesions = purpura rash, joint pain, neuropathy(mononeuritis multiplex)
-PAN, Wegners, Churg-Strauss, GCTA, Takayasu, Henoch-Sclone purpura, Cryogloulinemia, Behcet dz,
Wegener’s granulomatosis
sx? tx?
C dz! = CANCA, UR+ LR findsing, + kidney + otitis
dx = bx tx: steroids + cyclo
Churg-Strauss Syndrome
aka allergic angiitis = PANCA, Vasculitis, Eosinophilia & asthma
Giant Cell Temporal Arteritis
tx?
fever weight loss fatigue, jaw claudication, visual sx, HA, scalp tenderness/pain when brushing hair, decrease pulses in arm, aortic regurge
tx: steroids 1st then bx
Takayasu Arteritis
arteritis of the aorta = different pulses n shit
Cryoglobulinemia
vasculitis + fatigue, malaise, skin lesions, joint pain & ASSOCIATED WITH HEPATITIS C = TX HEP C AND WILL GO AWAY
Behcet Disease
sx? tx?
oral/genital ulcers, middle eastern ppl/asian, ocular involvment(uveitis, optic neuritis), skin lesions = pathergy = hyperreactivity to mild skin trauma, CNS disease
tx: prednisone and colchicine
Gout birefringent?
negative needles
tx of gout
NSAIDS, steroids then colchicine within 1st 24 hrs or as preventative
*allopurinol for prevention only do not use as acute tx
Calcium Pyrophosphate (Pseudogout) birefringent? what is this associated with?
positive rhomboid
- hyperparathyroidism & hemochromatosis
- *usually effects big joints
Carpel Tunnel Syndrome
nerve? whats the tunnel?
median nerve trapped under felxor retinaculum
Tinel & Phalen sign
tinel = pain when tapping median nerve phalen = pain with wrists at 90 degrees
*carpel tunnel syndrome
Dupuytren Contraction
hyperplasia of palmer fascia leading to nodule formation and contraction of 4-5th digits
what is dupuytren contraction associated with?
alcohol, cirrhosis
tx of dupuytren contraction
Triamcinolone > surgery
Plantar Fasciitis vs Tarsal Tunnel Syndrome
PF: tenderness at insertion, sever in morning, imporves with walking, tx NSAIDs will resolve
TTS: more painful with use, like carpel tunel of foot, tx avoid high heels, may need steroids, may need surgery
baker’s cysts
dx? tx?
posterior herniation of the synovium of the knee, usually seen with RA or OA; dx w/ U/S tx: NSAIDs or steroids
Morton Neuroma
sx
painful burning senation in the INTERDIGITAL WEB SPACE BETWEEN THE 3rd and 4th toes, tenderness when pressure is applied, shap intermitten pain radiating nto the toes that feels better with shoes off