Rheumatology Flashcards
In Fibromyalgia how long is the pain present before diagnosis can be made
3 Months
What Rheum condition presents with characteristics such as: Stiff after sleep, worsened by cold, stress and activity, Pain in back and neck worse.
Fibromyalgia
What conditions are associated with fibromyalgia?
Chronic fatigue syndrome, restless leg syndrome, Depression and anxiety, Irritable bladder, IBS, Migraines, painful periods,
What Rheum condition presents with characteristics such as: Flu-like illness followed by; weakness, back and neck pain and stiffness, tender muscle and tendons
Fibromyalgia
What is the Goal of pharmacological intervention in fibromyalgia
To aid associated symptoms like depression and difficulty sleeping
Name three management options for fibromyalgia
CBT, exercise and heated pools
what drugs are associated with drug induced lupus?
chlorpromazine, Methyldopa , Hydralazine, Isoniazid, d-penicillamine, minocycline
What Infection is linked to causing SLE
Epstein barr virus
what is the characteristics of the SLE rash
malar (butterfly) rah precipitated by sunlight and sparing of the naso-labial folds. erythmatous and well demarcated
What Cardiac conditions are linked with SLE
pericarditis, HTN and endocarditis
name three Respiratory conditions associated with SLE
Fibrosing alveolitis, Pulmonary Emboli
What renal conditions are linked with SLE
nephritis and GN
What antibody should be tested for diagnosis of drug induced lupus
anti-histone
What antibody Is 30% prevalent in polymyositis and dermatomyositis
Anti-Jo
What antibody Is prevalent in scleroderma
anti-centromere (70%)
ds-DNA is 70 % prevalent in what condition
SLE
what antibody is most sensitive to SLE
ANA
what antibodies is most specific to SLE
Anti-dsDNA and Anti smith
what antibodies are prevent in both SLE and Sjögren’s
Anti-Ro and anti La
What antibodies are most prevalent in sjögrens
Anti-Ro and anti La
anti-sm antibodies are more prevalent in what ethnic group in SLE patients
black African
What Rheum condition presents with characteristics such as: dry eyes, dry mucosa, fatigue and arthralgia
Sjögren’s
name three conditions associated with Sjögren’s
autoimmune thyroid disease, coeliacs, Primary bilary cirrhosis
What cancers are associated with Sjögren’s
B-call lymphoma, non-hodgkins lymphoma and parotid tumour
What clinical test contributes to diagnosis of Sjögren’s?
Schirmers test
What result in the Schirmers test is suggestive of Sjögren’s ?
less than 5mm/5mins
What results in antibody testing is suggestive of enteropathic arthritis
Seronegative
what antigen positive is heavily associated with enteropathic arthritis ?
HLA-D27
What Rhuem condition presents with only Symmetrical proximal muscle weakness and Skin lesions
Dermatomyositis
What three cancers are most associated with Dermatomyosistis
Lung, breast and ovarian
Photosensitive macular rash over back and shoulders is indicative of what Rheum condition
Dermatomyositis
It is a reddish-purple rash on the upper eyelids that is usually bilateral is what rash
Heliotrope rash
A heliotrope rash is in what condition
juvenile dermatomyositis
What systemic vasculitis affects medium sized vessels
Polyarteritis Nodosa and Kawasakis disease
What systemic vasculitis affects large sized vessels
Giant cell arteritis and takayasus arteritis
Name 4 conditions that are ANCA positive
Microscopic polyangitis, granuloatosis with polyangitis, eosiniophillic granulomatosis with polyangitis, HSP
What vasculits presents with: sudden blindness, jaw claudication and limb pain
Giant cell arteritis
What vasculits presents with: reduced BP and pulse in one arm and renal dysfunction
takayasus arteritis
What vasculits presents with: foot drop, abdomen pain and haemorrhage, gangrene, glomeronephritis, rash
polyarteritis Nodosa
What vasculits presents with: conjunctivitis, dry sore mouth, polymorphic rash, red and swollen palms,
kawasakis
What vasculits presents with: ENT symptoms (Epitaxisis, deafness), GN, neuropathy, pulmonary fibrosis
granulomatosis wth Polyangitis
What vasculits presents with: rash, Late onset asthma, GN, peripheral neuropathy
eosiniophillic granulomatosis with polyangitis
What vasculits presents with: Pulmonary fibrosis, GN, Rash, ENT symptoms, peripheral neuropathy,
Microscopic polyangitis
What vasculitis presents predominantly in turkey, Japan and Iran
Behçets disease
What vasculitis presents with genital ulcers, Eye lesions, skin lesions and Oral ulcers
Behçets disease
