Rheumatology Flashcards
Cryoglobulinaemia Type 1
Cryoglobulins precipitate in cold temperatures -> vasculitis
Associations:
Multiple myeloma
-> (old CRAB - 65yo, calcium high, renal failure, abdo pain/dehydration, bone pain)
Waldenstrom’s macroglubulinaemia
Serum ACE
Sarcoidosis
p-ANCA
Eosinophilic granulomatosis with polyangiitis
Ulcerative colitis
Primary sclerosing cholangitis
Rheumatoid arthritis
c-ANCA
Granulomatosis with polyangiitis
Anti-dsDNA
SLE
Anti-RNP
Mixed connective tissue disease
Anti-Jo1
Polymyositis
with lung involvement (ILD)
and fever
Pseudogout crystals
Weakly positive birefringent rhomboid shaped crystals
Gout crystals
Negatively birefringent needle shaped crystals
Symmetrical proximal muscle weakness
Raynaud’s
Respiratory muscle weakness
Interstitial lung disease
Condition?
Polymyositis
Polymyositis investigations
CK
Muscle biopsy
EMG
Anti-Jo1
Symmetrical proximal muscle weakness
Photosensitive
Macular rash over back and shoulders
Heliotrope rash in peri-orbital region
Dermatomyositis
Dermatomyositis associations
Connective tissue disorders
Malignancy (ovarian, breast, lung)
Marfan’s syndrome - abnormal protein
Fibrillin
HOCM - abnormal protein
Myosin
Joint hypermobility
Stretchy, fragile skin
Ehlers-Danlos syndrome
Tall, thin, long arms/legs/fingers
Upward dislocation of lens
Aortic regurgitation
Marfan’s syndrome
Autosomal dominant
Psoriatic arthritis criteria
- Inflammatory articular disease
- personal history of psoriasis
- negative RF
- Current dactylitis
discoid lupus erythematosus treatment
- Hydroxychloroquine
Rheumatoid arthritis x-ray findings
Peri-articular osteoporosis/osteopenia
AKI
Fever
Upper respiratory tract signs (epistaxis, earache, haemoptysis, crusting of nostrils, sinusitis/sinus pain, runny nose)
Granulomatosis with polyangiitis
HLA-B5
Behcet’s disease
HLA-B27
Ankylosing spondylitis
Reactive arthritis
Anti-mitochondrial antibodies (M2 subtype)
Primary biliary cirrhosis
-> IgM
Movement impaired in adhesive capsulitis
External rotation
