Rheumatology Flashcards
What antibody is found in limited systemic sclerosis?
Anti centromere antibodies
What combination of symptoms is seen in limited cutaneous systemic sclerosis (CREST syndrome)
Calcinosis, Raynauds, oesophageal dysmotility, sclerodactyly and telangiectasia
What antibody is found in SLE?
Anti DS DNA
What antibody is found in drug induced lupus?
Anti histone antibodies
What antibody is found in dermatomyositis?
Anti Mi 2 - very specific
ANA are more commone
What antibody is found in diffuse cutaneous systemic sclerosis?
Anti SCL 70
What is the most common cause of death in diffuse cutaneous systemic sclerosis?
Respiratory involvement - interstitial lung disease and pulmonary arterial hypertension
What disease patterns are seen in psoriatic arthritis?
- Rheumatoid like polyarthritis
- Asymmetrical oligoarthritis
- Sacroilitis
- DIP joint disease
- Arthritis mutilins
What is pagets disease?
A disease of increased but uncontrolled bone turnover. It is primarily a disorder of osteoclasts
What are the biochemical findings in pagets disease of bone?
Raised ALP
Normal calcium and phosphate
What is the treatment for pagets disease?
Bisphosphonates
What features are associated with ankolysing spondylitis?
Apical fibrosis Anterior uveitis Aortic regurgutation Achilled tendonitis AV node block Amyloidosis Cauda equina syndrme
What antibodies are associated with mixed connective tissue disease?
Anti ribonuclear (anti RNP)
What type of collagen is abnormal in osteogenesis imperfecta?
Type 1
What is the mechanism of action of azathioprine?
Inhibition of purine synthesis
