Immunology

Question 1

What are the symptoms of C1 inhibitor protein deficiency?

Answer 1

Hereditary angioedema - likely mechanism is due to uncontrolled release of bradykinin resulting in oedema.

Question 2

What are the symptoms of C1q, C1rs, C2, C4 deficiency?

Answer 2

These are the classical pathway components. Deficiency predisposes to immune complex disease such as SLE and henoch schonlein purpura

Question 3

What are the symptoms of C3 deficiency?

Answer 3

Recurrent bacterial infections

Question 4

What are the symptoms of C5 deficiency?

Answer 4

predisposition to leiner disease

Recurrent diarrhoea, wasting and seborrhoeic dermatitis.

Question 5

What are the symptoms of C5 - 9 deficiency?

Answer 5

These are the proteins that encode the membrane attack complex. Deficiency means people are more prone to neisseria meningitidis