RHEUMATOID FACTOR Flashcards
an example of systemic autoimmune disorder
rheumatoid arthritis
Thus, infiltration of the inflamed’ synovium with ,,, are evidences of immunologjc activity with the joint.
T and B lymphocytes
plasma certs
dendritic cells
mast cells
granulocytes
The lesions in the rheumatoid joints show an increase
in cell lining the synovial membrane and the
formation of a ,,, , a sheet in the inflammatory
granulation tissue that grows into joint space and
invades the cartilage.
Pannus
The strongest environmental risk factor for RA is ,,, known to activate endogenous sources of free radicals.
smoking
cigarette smoke
The patients with RA are positive for
Rheumatoid Factor
Citrullinated cyclic peptide
Impaired antioxidant systems caused by ,,, which
have a role in the etiology of RA.
free radicals
is the antibody most often with the
IgM class and is directed in the Fc portion of IgG.
Rheumatoid factor
(Local bone erosion) Two key antibodies seen in RA are
Rheumatoid Factor (RF)
anti-citrullinated cyclic peptide
is another feature that is characteristic of the pathology of RA
Local bone erosion
play a role in the pathogenesis of RA by increasing the macrophage activity and enhancing antigen presentation of T cells by APC
rheumatoid factor
Characteristics that increase risk in rheumatoid arthritis
Age
Sex
Genetics/inherited traits
Smoking
History of live births
Early Life Exposures
Obesity
Characteristics that can decrease risk in rheumatoid arthritis
Breastfeeding
are antibodies directed against antigenic sites in the Fo fragment of human and animal IgG.
Rheumatoid factors
positive test results in RF may be observed in a variety of disorders, such as
Sjoren’s syndrome
hepatitis
syphilis
specimens unsuitable for testing
Lipemia
hemolysis
contamination with bacteria
