ANTIBODIES AND COMPLEMENT Flashcards
Amino terminal end (light and heavy chains), specificity, antigen binding site
Variable region
Carboxyl terminal end, binds to effector cells
Constant region
Primary, constant on heavy chains
Isotypes
Subtle, heavy and light chains
Allotype
Unique, variations on heavy and light, specific
Idiotype
First antibody, classical, agglutination
IgM
Most abundant, can across placenta except igG2, major immunoglobulin in serum
IgG
Allergic responses and parasitic infection
IgE
monomer and dimer
IgA
IgA that has anti- inflammatory agent
IgA1
IgA that has secretory component
IgA2
Immunocompetent and unstimulated b lymphocytes
IgD
Initial force
Overall force
Affinity
Avidity
Classic
1 rxn = multiple binding sites
Complement fixation
IgG binds to sites on toxins/viruses
Neutralization
Purified immunoglobulin
Single fusion type hybridinoma cell
Monoclonal antibodies
Intestinal epithelial cells
C1
Adipose tissues
Factor d
Bind antibodies to antigen
Binds to CH2 domain
Classical pathway
Calcium dependent
C1qrs
Resembles a collagen molecule
C1q
Initiates the assembly of the MAC
C5b
Disrupts the integrity of the cell membrane -> water influx
Membrane attack complex
Activated when there is presence of surface microorganisms
Alternative pathway
Makes alternative pathway rapid and efficient
Antibody independent activation
Hydrolyzed by water then binds to factor B
C3
MBL binds to mannose
Lectin pathway
Regulatory protein of classical and lectin pathways
CI-INH
Inactivates complement components
Factor 1
Dissociation of pathway
DAF
Principle soluble regulator
Factor H
Binds to fluid phase
Inhibits CA polymerization
S-protein
Targets later stage of MAC assembly
MIRL
