ANTIBODIES AND COMPLEMENT

Question 1

Amino terminal end (light and heavy chains), specificity, antigen binding site

Answer 1

Variable region

Question 2

Carboxyl terminal end, binds to effector cells

Answer 2

Constant region

Question 3

Primary, constant on heavy chains

Answer 3

Isotypes

Question 4

Subtle, heavy and light chains

Answer 4

Allotype

Question 5

Unique, variations on heavy and light, specific

Answer 5

Idiotype

Question 6

First antibody, classical, agglutination

Answer 6

IgM

Question 7

Most abundant, can across placenta except igG2, major immunoglobulin in serum

Answer 7

IgG

Question 8

Allergic responses and parasitic infection

Answer 8

IgE

Question 9

monomer and dimer

Answer 9

IgA

Question 10

IgA that has anti- inflammatory agent

Answer 10

IgA1

Question 11

IgA that has secretory component

Answer 11

IgA2

Question 12

Immunocompetent and unstimulated b lymphocytes

Answer 12

IgD

Question 13

Initial force
Overall force

Answer 13

Affinity
Avidity

Question 14

Classic
1 rxn = multiple binding sites

Answer 14

Complement fixation

Question 15

IgG binds to sites on toxins/viruses

Answer 15

Neutralization

Question 16

Purified immunoglobulin
Single fusion type hybridinoma cell

Answer 16

Monoclonal antibodies

Question 17

Intestinal epithelial cells

Answer 17

C1

Question 18

Adipose tissues

Answer 18

Factor d

Question 19

Bind antibodies to antigen
Binds to CH2 domain

Answer 19

Classical pathway

Question 20

Calcium dependent

Answer 20

C1qrs

Question 21

Resembles a collagen molecule

Answer 21

C1q

Question 22

Initiates the assembly of the MAC

Answer 22

C5b

Question 23

Disrupts the integrity of the cell membrane -> water influx

Answer 23

Membrane attack complex

Question 24

Activated when there is presence of surface microorganisms

Answer 24

Alternative pathway

Question 25

Makes alternative pathway rapid and efficient

Answer 25

Antibody independent activation

Question 26

Hydrolyzed by water then binds to factor B

Answer 26

C3

Question 27

MBL binds to mannose

Answer 27

Lectin pathway

Question 28

Regulatory protein of classical and lectin pathways

Answer 28

CI-INH

Question 29

Inactivates complement components

Answer 29

Factor 1

Question 30

Dissociation of pathway

Answer 30

DAF

Question 31

Principle soluble regulator

Answer 31

Factor H

Question 32

Binds to fluid phase
Inhibits CA polymerization

Answer 32

S-protein

Question 33

Targets later stage of MAC assembly

Answer 33

MIRL