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Jason's MD2 Intersession 2 > Rheumatoid Arthrititis > Flashcards

Rheumatoid Arthrititis Flashcards

1
Q

mechanism of reactive arthritis?

A

immune complex mediated, post-infectious cross reaction/inflam

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2
Q

mechanical joint pain time frame?

A

months to years

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3
Q

mechanical joint pain describe?

A

improved by rest
not much swelling
little stiffness
worsen slowly

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4
Q

describe inflammatory joint pain

A 
acute/subacute
worsen quickly
improve with movement
worse with rest
swelling
morning stiffness (immobility)
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5
Q

‘slapped cheek’ syndrome which virus?

A

Parvovirus B19

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6
Q

RA risk factors?

A

smoking

FHx

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7
Q

How does lupus differ from RA?

A

no synovitis

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8
Q

how to check for MCP swelling?

A

effaced gutters when making a fist

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9
Q

investigations to dx Rheumatoid Arthritis?

A

Rheumatoid Factor
Serological: Anti-CCP (antibodies)
ANA to exclude lupus

FBE: CRP, ESR (more general)

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10
Q

what two antibodies for dx of RA?

A

ACPA+ (more specific) Anticitrullinated Peptide Antibody

RF+

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11
Q

what condition can mimic rheumatoid arthritis??

A

reactive arthritis

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12
Q

Pharmacological Rx of RA?

A

simple analgesics
NSAIDS
DMARDS
Biologics

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13
Q

DMARDS - 4 main ones

A

hydroxychloroquine
sulphasalazine
methotrexate
leflunomide

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14
Q

Biologics 4 main ones

A

TNF inhibitors
B-cell - rituximab
cell adhesion inhibitors - abatacept
IL-6 inhibitor - tocilizumab

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15
Q

RA when all else fails besides surgery

A

prednisolone

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16
Q

how does cortisone injection work?

A

crystal of steroids are phagocytosed by neutrophils, neutralizing them locally

17
Q

treatment paradigm in Rheumatology these days?

A

combination therapy: 3 drugs

Methotrexate
sulfasalazine
hydroxychloroquine
azathioprine

remission and maintenance therapy

18
Q

how to check for synovitis, cartilage damage, bone oedema/erosions radiologically?

A

MRI

19
Q

DDx for pain and stiff hands and feet for 6/52?

A

RA
Lupus
Reactive arthritis

20
Q

what can you give pregnant woman with RA

A

prednisolone doesn’t cross placenta, gets metabolized

Jason's MD2 Intersession 2 (15 decks)

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