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PHARM 2 > Rheumatoid Arthritis > Flashcards

Rheumatoid Arthritis Flashcards

1
Q

3 classes of tx for RA

A

1) NSAIDs
2) glucocorticoids
3) DMARDs

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2
Q

1st DOC for RA

A

DMARD

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3
Q

leflunomaide liver function concern

A

leflunomide + MTX = inc risk of hepatotoxicity

must monitor

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4
Q

which drugs do not prevent disease progression or joint destruction in RA

A

NSAIDs and corticosteroids

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5
Q

which drug reduces/prevents joint damage and can delay progression

A

DMARDs

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6
Q

Biological vs nonbiological: MTX

A

non biological

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7
Q

Biological vs nonbiological: leflunomide

A

non biological

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8
Q

Biological vs nonbiological: hydroxychloroquine

A

non biological

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9
Q

Biological vs nonbiological: sulfasalazine

A

non biological

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10
Q

Biological vs nonbiological: cyclosporine

A

non biological

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11
Q

Biological vs nonbiological: azathioprine

A

non biological

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12
Q

Biological vs nonbiological: cyclophosphamide

A

non biological

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13
Q

Biological vs nonbiological: adalimumab

A

biological - anti TNF

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14
Q

Biological vs nonbiological: infliximab

A

biological - anti TNF

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15
Q

Biological vs nonbiological: etanercept

A

biological - anti TNF

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16
Q

Biological vs nonbiological: anakinra

A

biological

for mod to severe RA

17
Q

Biological vs nonbiological: rituximab

A

biological - usually given with MTX or another nonbiological DMARD

18
Q

Biological vs nonbiological: abatacept

A

biological

given to pt who didn’t respond to non-biologicals or anti-TNF

19
Q

cyclosporine AE

A

nephrotoxicity

20
Q

which drug tx refractory RA

A

azathioprine

21
Q

which drug is reserved for the most severe cases of rheumatoid

A

cyclophosphamide

22
Q

DOC for RA

A

MTX - mild, mod, or severe RA

23
Q

when are biological DMARDs appropriate

A

more moderate to severe RA

24
Q

if pt doesn’t respond to MTX, what next

A

try combo leflunomide + MTX

25
Q

least toxic of all DMARDs

A

hydroxychloroquine

26
Q

cyclophosphamide AE

A

long term use - inc risk of infection and malignancy

27
Q

anti-TNFalpha’s (3)

A

adalimumab
infliximab
etanercept

28
Q

initial tx for RA

A

non-biological DMARD (MTX) + NSAID or corticoid

if moderate: first line = TNF-inhibitors - biological DMARD + non-biological DMARD

29
Q

mildest RA cases tx

A

hydroxychloroquine

sulfasalazine

30
Q

first line DOC for RA in moderate to severe

A

TNF-inhibitors

PHARM 2 (18 decks)

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