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PHARM 2 > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

celecoxib

A

COX 2 selective inhibitor

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2
Q

meloxicam

A

COX 2 selective inhibitor

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3
Q

diclofenac

A

nonselective COX inhibitor

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4
Q

ibuprofen

A

nonselective COX inhibitor

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5
Q

indomethacin

A

nonselective COX inhibitor

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6
Q

ketorolac

A

nonselective COX inhibitor

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7
Q

naproxen

A

nonselective COX inhibitor

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8
Q

piroxicam

A

nonselective COX inhibitor

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9
Q

what is contraindicated with gout

A

ASA - inhibits urate excretion at low doses

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10
Q

tx of gastric damage induced by NSAIDs (3)

A

misoprotsol
PPI
H2 blockers

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11
Q

only selective COX2 inhibitor in US

A

celecoxib

rofecoxib and valdecoxib = withdrawn
meloxicam = not as selective for COX-2 as celecoxib

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12
Q

NSAID AE

A

1) GI: gastric damage
2) CV: inc risk of CV events
3) renal: dec RBF, analgesic nephropathy
3) ASA HS: b/c of excess LK synthesis (shunted after blocked COX)

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13
Q

NSAID contraindications (illnesses)

A

HTN, HF, CKD pts = can elevate BP and reduce effects of anti-HTN meds, cause fluid retention, worsen kidney function

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14
Q

phenacetin AE

A

analgesic nephropathy

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15
Q

celecoxib AE

A

sulfonamide = may cause HS rxn

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16
Q

medications contraindicated with NSAIDs

A

1) ACE-I
2) corticosteroids
3) warfarin

17
Q

Triple Whammy

A

risk of acute kidney injury when ACE-I (or ARB) combined with diuretic and NSAID

  • NSAID: constrict afferent = dec GFR
  • ACE-I: dilate efferent = dec GFR
  • diuretics: dec PV = dec GFR

must monitor these pt for creatinine and K+

18
Q

ASA effects on CO2

A

uncouple oxidative phosphorylation = inc CO2 - inc breathing

at toxic levels of ASA = respiratory paralysis

19
Q

ASA dosage uses

A

lowest: cardioprotective/antiplatelet
low: analgesic and antipyretic
high: anti-inflam, AE of tinnitus

20
Q

ASA AE

A

1) epigastric distress
2) prolonged BT
3) Reye’s
4) Hypersensitivity
5) uricosuric effects: low doses of ASA compete with uric acid for secretion = dec uric acid secretion
6) hepatic effects: hepatic injury with high dose

21
Q

ASA contraindications

A

elevated uric acid levels

chronic liver disease

22
Q

what drug is contraindicated in pt with sulfa allergy

A

celecoxib

PHARM 2 (18 decks)

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