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PHARM 2 > migraine > Flashcards

migraine Flashcards

1
Q

two classes for migraine tx

A

1) acute tx

2) prevention

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2
Q

mild to moderate migraines

A

non-opioids
acetaminophen
NSAIDs

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3
Q

mod to severe migraine DOC

A

triptans

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4
Q

triptan

A

agonist 5 HT1D/1B

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5
Q

triptan AE

A

vasoconstrictors: so contraindicated in coronary/cerebrovascular disease

vasospams can occur - chest tightness

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6
Q

ergotamine/dihydroergotamine

A

agonist at alpha, 5HT, D2

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7
Q

prevention of migraines 1st line (3)

A

beta blockers
valproate
topiramate

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8
Q

2nd/3rd line prevention migraines

A 
TCA
SNRIs
CCB
gabapentin
ACEI/ARB
botulinum
NSAIDs
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9
Q

beta blockers used in migraines (first line)

A 
atenolol
timolol
nadolol
metoprolol
propanolol
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10
Q

valproate MOA

A

block Na and T type Ca VG channels

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11
Q

topiramate MOA

A

block VG Na. Antagonist at GABA(a) and glutamate receptor

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12
Q

TCAs used in migraine tx

A

amitryptaline
nortryptiline
imipramine

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13
Q

SNRIs used in migraine tx

A

venalfaxine

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14
Q

CCBs used in migraine tx

A

verapamil: greatest efficacy of CCBs

gabapentin - dec glutamate release

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15
Q

ACEIs and ARBs used in migraine tx

A

lisinopril

candesartan

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16
Q

NSAIDs used in migraine tx

A

naproxen, ibuprofen

for frequent but mild migraines

17
Q

ergot alkaloids AE

A

n/v
vascular occlusion with gangrene in OD cases
dihydroergotamine = weaker vasoconstricter, less AE

contraindicated in arterial dz or uncontrolled HTN

18
Q

valproate AE

A

GI, thrombocytopenia, teratogenic

19
Q

topiramate AE

A

somnolence, fatigue, cognitive slowing, acute myopia, glaucoma, hyperthermia, renal stones
teratogenic

20
Q

TCA AE

A

sedation
dry mouth
weight gain

21
Q

TCA MOA

A

inhibit NE and serotonin reuptake

22
Q

venlafaxine AE

A

nausea, constipation, insomnia, sexual dysfunction

PHARM 2 (18 decks)

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