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Rheum / MSK Flashcards

1
Q

PBC

A

Females
Pruritis, Xanthomas, Anti-Mitochondrial Abs

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2
Q

PSC

A

p-ANCA Abs
Bile duct inflammation
IBD, Onion-skinnig

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3
Q

Type I Auto-immune hepatitis

A

Young women
Anti-SM

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4
Q

Type II auto-immune hepatitis

A

Kids
Anti-LKM

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5
Q

Bullous Pemphigoid vs Vulgaris

A

Bullous: anti-HemiDesmosome, sub-epithelial
Vulgaris: +Mouth, anti-Desmosome

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6
Q

Dermatitis Herpitiformis

A

Vesicles on anterior thigh
anti-BMZ
Anti-Endomysial

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7
Q

Dermatomyositis

A

Anti-Jo-1
Myositis with a rash
Associated with occult malignancy

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8
Q

Anti-GAD abs

A

DM 1

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9
Q

Drug-Induced Lupus

A

Anti-Histone Ab
Hydralazine, INH, Phenytoin, Procainamide, Penicillamine, Ethosuximide

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10
Q

Gastritis A

A

Anti-Parietal Cell Ab
Atrophic gastritis
Associated with Adenocarcinoma

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11
Q

Goodpasture

A

Anti-GBM
Lung and kidney
Can progress to RPGN

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12
Q

Hashimoto’s

A

Anti-Microsomal Ab

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13
Q

ITP

A

Anti-Platelet Ab
Anti-GP2b3a

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14
Q

Mixed connective tissue disease

A

Anti-RNP

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15
Q

Membranoproliferative Glomerulonephritis II

A

Anti-C3 convertse (nephritic factor) Ab

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16
Q

Paroxysmal hemolysis

A

Donath Landsteiner Ab
Bleed when cold

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17
Q

Polyarteritis Nodosa

A

p-ANCA
Gut, kidneys, nervous system
Hep B association

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18
Q

Post-Strep glomerulonephritis

A

ASO ab
Nephritic with compliment deposition
3 weeks post-infection

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19
Q

Scleroderma

A

Anti-Scl70 (Topo 1)
Fibrosis, tight skin, Masked faces

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20
Q

Sjogren’s

A

Anti-SSA
Increased NHL risk

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21
Q

SLE

A

Anti-ds DNA / SM / Cardiolipin
Rheumatoid Factor+
False+ VRDL
FTA abs confirm

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22
Q

SLE Cerebritis

A

Anti-Neuronal
Anti-Ribosomal

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23
Q

Warm hemolysis

A

Anti-Rh
Bleeds at body temperature

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24
Q

Wegner’s (GPA)

A

c-ANCA
ENT, Lungs, Kidney

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25
Q

Berger’s

A

IgA disease 2 weeks post-vaccine
Serum Sickness
(Buerger’s is the finger necrosis w/ smoking thing)

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26
Q

Alport’s

A

IgA disease 2 weeks after diarrhea, HSP, Polio

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27
Q

Myotonic Dystrophy

A

Birds beak face
Can’t let go when shaking hands

28
Q

Myasthenia Gravis

A

Anti-ACH postsynaptic Ab
Get weaker as the day goes on
Rule out Thymoma

29
Q

Lambert Eaton

A

Small Cell Lung CA
Get stronger as the day goes on

30
Q

MS

A

Anti-Myelin Abs
Vision disturbances, UMN, decreased sensation, wax and wane
Each MS attack gets worse

31
Q

Metachromatic leukodystrophy

A

Arylsulfatase deficiency
Child who presents like MS

32
Q

AT

A

IgA deficiency
Spider veins

33
Q

Friedrich’s Ataxia

A

Retinitis Pigments
Scoliosis

34
Q

Adrenal Leukodystrophy

A

Broken Carnitine Shuttle (CAT-1)
Adrenal Failure (X-Recessive)
Long chain fatty acid stuck in cytoplasm

35
Q

Werdig-Hoffman

A

Fasciculations in a newborn
Failure of anterior horns to develop

36
Q

Polio

A

Asymmetric fasciculations in kids
2 weeks after Gastroenteritis

37
Q

Choreoathetosis

A

Dance like movements, wringing of hands, quivering and unsteady hands

38
Q

Atonic cerebral palsy

A

No muscle tone, floppy

39
Q

Seborrheic keratosis

A

Tan-brown-black stuck on appearance

40
Q

Stucco keratoses

A

Barnacles
White-flesh colored stuck on papules

41
Q

Dermatosis papulosa nigra

A

Variant of SK on the face, neck of dark-skinned people

42
Q

Keratoacanthoma

A

smooth, dome-shaped, red papule
Central filled keratin crater
Precursor to SCC

43
Q

Epidermal nevus

A

hamartomas that follow Blaschkos lines

44
Q

Syringomas

A

Sweat duct tumor on lower eyelid

45
Q

Erysipelas

A

Superficial cellulitis along lymph channel

46
Q

Woods light

A

Tinea versicolor
Tuberous Sclerosis
Helps see HYPO-pigmented lesions

47
Q

Tinea Versicolor

A

Pityrosporum
KOH prep spaghetti and meatballs

48
Q

Leishmaniosis

A

Protozoan from Sandflies
Painless ulcer with central crater

49
Q

Molluscum contagiosum cause

50
Q

Dew drop on rose petal

A

Varicella / Chickenpox
HHV3

51
Q

Cafe au lait spots

A

NF1 and McCune Albright

52
Q

HLA-B27

A

Ankylosing Spondylitis
Psoriatic, Enteropathic, Reactive Arthritis

53
Q

HLA-DR4

A

Rheumatoid Arthritis

54
Q

HLA-C

55
Q

HLA-DQ2/8

56
Q

HLA-B8

57
Q

HLA-A3

A

Homochromoatosis

58
Q

Leg cutaneous nerve roots

A

Back, around to lateral foot: S1 (between L5-S1)
Medial foot and leg, across thigh: L4
Middle of foot, lateral leg: L5

59
Q

C5

A

Biceps reflex, deltoid sensation, forearm flexion

60
Q

C6

A

Brachioradialis reflex
Lateral forearm and first 2 digit sensation
Wrist extionsion, bicep flexion

61
Q

C7

A

Tricep reflex
Middle finger sensation
Arm extionsion, wrist flexion

62
Q

C8

A

4-5 digit and medial forearm sensation
Finger flexion

63
Q

T1

A

Medial aspect of arm sensation
intercostal motor

64
Q

Treat Sjogrens

A

Mild: Secreatagogues (Civemiline, pilocarpine)
Systemic: Glucocorticoids
Severe: HCQ, DMARDs

65
Q

Treat Celiac associated dermatitis herpitiformis

A

Dapson and d/c gluten

Clues (14 decks)

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