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Medicine SHELF Prep > Rheum > Flashcards

Rheum Flashcards

1
Q

Causes of additive arthritis

A

OA, RA

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2
Q

Causes of migratory arthritis

A

Gonococcal, rheumatic fever

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3
Q

Causes of intermittent arthritis

A

Gout, Pseudogout, SLE

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4
Q

Which diagnosis? Pencil in cup deformity

A

Psoriatic arthritis

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5
Q

Which diagnosis? Squaring of vertebral bodies, enthesophytes

A

Ankylosing spondylitis

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6
Q

Which diagnosis? Associated with uveitis, conjunctivitis, oral ulcers

A

Reactive arthritis

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7
Q

Which diagnosis? Positively birefringent crystals

A

CPPD

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8
Q

Target uric acid level on allopurinol

A

<6

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9
Q

Which diagnosis? Associated with painless pustular lesions

A

Gonococcal arthritis

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10
Q

Tx septic arthritis: staph/strep (3)

A

nafcillin, oxacillin, cephazolin

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11
Q

Tx septic arthritis: Neisseria

A

Ceftriaxone (+ azithromycin for chlamydia)

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12
Q

Tx septic arthritis: Pseudomonas

A

3rd-4th cephalosporin + aminoglycoside

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13
Q

Tx septic arthritis: culture negative

A

3rd-4th cephalosporin +/- vancomycin

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14
Q

Tx RA First-line

A

Methotrexate

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15
Q

C/I Methotrexate (3)

A

Liver disease, lung disease, immunosuppression

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16
Q

Tx RA Second-line

A

Hydroxychloroquine, Leflunomide, Sulfasalazine

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17
Q

MOA Methotrexate

A

Folic acid antimetabolite

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18
Q

Tx RA exacerbations (2)

A

NSAIDs, steroids

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19
Q

Lupus Mucocutaneous (4)

A

Malar, discoid, mouth ulcers, photosensitivity

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20
Q

Lupus Internal Findings (4)

A

Pleuritis/pericarditis, renal disease, seizures, arthritis

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21
Q

Lupus Lab criteria

A

Antibodies, ANA, Hematologic

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22
Q

Lupus antibodies

A

Anti-smith, anti-dsDNA, anti-phospholipid

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23
Q

Dx Antiphospholipid Syndrome

A

1 Clinical + 1 Lab

24
Q

Antiphospholipid syndrome clinical criteria (2)

A

Recurrent pregnancy loss, thrombosis

25
Q

Antiphospholipid syndrome lab criteria (3)

A

Lupus anticoagulant, Anticardiolipin antibody, Beta-2-glycoprotein 1 antibody

26
Q

Dx Ankylosing Spondylitis

A

MRI SI Joint

27
Q

Tx Ankylosing Spondylitis

A

TNF-alpha Inhibitors

28
Q

TNF-alpha Inhibitors (3)

A

Infliximab, etanercept, adalimumab

29
Q

Which diagnosis? acute lower extremity arthritis, usually resolving within 4-6 months

A

Reactive Arthritis

30
Q

Tx reactive arthritis

A

NSAIDs (first-line)

31
Q

Tx Axial enteropathic arthritis or psoriatic arthritis

A

TNF-alpha Inhibitors

32
Q

Tx Psoriatic arthritis

33
Q

Polymyositis/Dermatomyositis Antibodies (3)

A

Anti-Jo1, Anti-Mi-2, Anti-SRP

34
Q

Tx Poly/Dermatomyositis (Acute)

A

Prednisone

35
Q

Tx Poly/Dermatomyositis (Maintenance) (2)

A

MTX or azathioprine

36
Q

CREST

A

Calcinoshs, Raynaud, Esophageal Dysmotility, Sclerodactyly, Telangiectasias

37
Q

Scleroderma Antibodies

A

Anti-Scl-70 (topoisomerase 1)

38
Q

Which diagnosis? Red sclerae, enlarged parotid glands, periodontal disease

A

Sjogren Syndrome

39
Q

Dx Sjogren Syndrome

A

Salivary Gland Biopsy

40
Q

Tx Sjogren Syndrome

A

Parasympathomimetics (pilocarpine, cevimeline

41
Q

Tx Fibromyalgia (first-line)

A

Exercise, CBT

42
Q

Which diagnosis? Anti-U1-RNP

A

Mixed Connective Tissue Disease

43
Q

Which diagnosis? spiking fevers, arthralgias, salmon-colored rash

A

Adult Onset Still Disease

44
Q

Dx Giant cell arteritis

A

Temporal artery biopsy

45
Q

Tx Giant cell arteritis

A

Steroids (even before biopsy)

46
Q

Which disease? Claudication, vascular bruits, and aortic regurgitation in young women

A

Takayasu Arteritis

47
Q

Which disease? Necrotizing vasculitis leading to aneurysm formation; presenting with mesenteric ischemia, muscle pain, renal disease, and skin findings

A

Polyarteritis Nodosa

48
Q

Dx Polyarteritis Nodosa

A

Aneurysms on imaging, biopsy

49
Q

Which disease? upper respiratory tract, lower respiratory tract and renal involvement?

A

Granulomatosis with Polyangiitis

50
Q

Antibody in Granulomatosis with Polyangiitis

51
Q

Tx Granulomatosis with Polyangiitis

A

Steroids, cyclophosphamide

52
Q

Which disease? asthma, allergic rhinosinusitis, glomerulonephritis, mononeuritis multiplex

A

Eosinophilic Granulomatosis with Polyangiitis

53
Q

Tx Eosinophilic Granulomatosis with Polyangiitis

A

Steroids, cyclophosphamide

54
Q

Which disease? Glomerulonephritis, pulmonary hemorrhage, palpable purpura, arthralgias/myalgias

A

Microscopic Polyangiitis

55
Q

Tx Microscopic Polyangiitis

A

Steroids, cyclophosphamide

56
Q

Labs in cryoglobulinemia

A

+RF, C4 decrease out of proportion to C3

57
Q

Tx Cryoglobulinemia (3)

A

Steroids, rituximab, plasma exchange

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