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Medicine SHELF Prep > Heme > Flashcards

Heme Flashcards

1
Q

Tx thalassemia (2)

A

Folic acid, hydroxyurea

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2
Q

Iron studies in anemia of chronic disease

A

Low iron, low transferrin, high ferritin

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3
Q

Dx hereditary spherocytosis

A

osmotic fragility test

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4
Q

Which diagnosis? Anemia, thrombocytopenia, and neurologic symptoms

A

TTP

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5
Q

Which diagnosis? Anemia, mild thrombocytopenia, AKI

A

HUS

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6
Q

Which diagnosis? Intra-erythrocytic parasites

A

Babesiosis, Malaria

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7
Q

Reason for newborn screening for sickle cell disease

A

Prophylactic PCN x5 years (prevent pneumococcal disease)

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8
Q

Most common cause of death in SCD

A

Acute chest syndrome

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9
Q

Tx of sickle cell anemia (2)

A

folate, hydroxyurea

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10
Q

Tx of SCD CKD (2)

A

EPO, ACEI

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11
Q

Severe cause of ITP

A

IIB/IIIA Inhibitors (Abciximab, eptifibatide, tirofiban)

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12
Q

Screening for what disease is indicated in ITP?

A

HIV

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13
Q

First-line tx of ITP

A

glucocorticoids or IVIG

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14
Q

Indications for ITP treatment (3)

A

Plt <10,000; active bleeding; Plt <50,000 and new dx

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15
Q

Which disease? Antibodies to ADAMTS13 protein

A

TTP-HUS

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16
Q

Tx TTP-HUS

A

Plasma exchange/glucocorticoids in severe cases

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17
Q

Which diagnosis? hypocellularity with increased fatty deposits on bone marrow biopsy

A

Aplastic anemia

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18
Q

Tx aplastic anemia (3)

A

HSCT, Cyclosporine, anti-thymocyte globulin

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19
Q

Dx AML

A

> 20% blasts on bone marrow biopsy

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20
Q

APML mutation

A

t(15;17)/RAR

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21
Q

Tx AML (2)

A

idarubicin, cytarabine

22
Q

Mutation in polycythemia vera

A

JAK2

23
Q

Tx of polycythemia vera

A

Phlebotomy

24
Q

Mutation in CML

A

t(9;22)/BCR-ABL

25
Q

Tx CML

A

Imatinib

26
Q

Dx essential thrombocythemia

A

Plt>600,000; JAK2 negative

27
Q

Which diagnosis? M protein <30, plasma cells <10%

A

MGUS

28
Q

Which diagnosis? Monoclonal IgM gammopathy, anemia, lymphadenopathy

A

Waldenstrom Macoglobulinemia

29
Q

Dx multiple myeloma

A

Plasma cells >10% on bone marrow biopsy or M protein >3.5g IgG

30
Q

Tx Multiple Myeloma

A

Induction therapy then autologous HSCT (age <75)

31
Q

Inheritance vWD

A

AD

32
Q

Dx vWD

A

Ristopetin cofactor assay

33
Q

Tx vWD

A

desmopressin

34
Q

Inheritance Hemophilia

A

XR

35
Q

Reversal of NOACs

A

Prothrombin Complex Concentrate

36
Q

Inheritance Protein C Deficiency

A

AR

37
Q

Inheritance Protein S Deficiency

A

AD

38
Q

Inheritance Antithrombin deficiency

A

AD

39
Q

Dx FVL

A

FVL Gene mutation

40
Q

Dx Hyperhomocyteinemia

A

Fasting plasma homocysteine levels

41
Q

Cause of delayed hemolytic transfusion reaction

A

Minor non-ABO antibodies

42
Q

Which transfusion reaction? dyspnea, cough, cyanosis, edema, elevated BNP; 1-2 hours

A

TACO

43
Q

Which transfusion reaction? drop in hemoglobin, jaundice, fever; 3-10 days

A

Delayed hemolytic transfusion reaction

44
Q

Which transfusion reaction? Fever, flank pain, red/brown urine

A

Acute Hemolytic transfusion reaction

45
Q

Which transfusion reaction? dyspnea, hypoxia, bilateral infiltrates on CXR; within 6 hours

A

TRALI

46
Q

Which transfusion reaction? fever/chills within 1-6 hours

A

Febrile reaction

47
Q

Prevention of transfusion-related anaphylaxis/allergy

A

Washing of cellular blood products

48
Q

Which transfusion reaction? Severe pancytopenia, diarrhea, skin rash, liver test abnormalities

A

Graft vs. Host disease

49
Q

Prevention of GvHD

A

Irradiation of blood products

50
Q

Tx TACO

A

Diuretics, oxygen

Medicine SHELF Prep (12 decks)

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