Onc Flashcards
Lung Ca Screening Indications
Age 55-80, 30py hx (within past 15 yrs)
Lung Ca Screening Test
Low-Dose CT
Lung Ca Staging
CT Chest/Abd, PET-CT chest
Absolute indication for lung nodule biopsy
> 1.5cm
Which Lung Ca stage? Mediastinal involvement
III
Which Lung Ca stage? Ipsilateral node positive
II
Tx NSCLC Stage I-II
Surgery (adjuvant ctx for 1B+)
Tx NSCLC Stage III
Neoadjuvant Ctx, then surgery
Tx SCLC
Cisplatin + etoposide
Eval palpable lump under 30, more than 2 menstrual cycles
US
Eval palpable lump age over 30
Mammogram
Eval BIRADS 1-3
US
Eval BIRADS 4-5
Biopsy
Colorectal Ca Screening PSC
annual colonoscopy
Tx colorectal cancer: indications for chemotherapy
Stage III+ (node-positive)
Tx rectal cancer: indications for radiation therapy
Stage II+
Tx colorectal cancer regimen
5-FU + leucovorin + oxaliplatin
Cervical cancer staging
CT abd/pelvis, CXR
Prostate Ca: indications for CT abd/pelvis and bone scan
PSA>10 or Gleason>7
Tx prostate Ca hormone therapy
Leuprolide/goserelin + androgen inhibitor (flutamide or bicalutamide)
Indication for melanoma SLNB
thickness >1mm
Precursor lesion to melanoma
Dysplastic nevus
Precursor lesion to squamous cell carcinoma (skin)
Actinic keratosis
Indication for interferons in melanoma
Node-positive
Dx Lymphoma
Excision lymph node biopsy
Tx Hodgkin Lymphoma
ABVD: doxorubicin, bleomycin, vinblastine, dacarbazepine
What testing is indicated in a patient with new dx of NHL?
HBV, HCV, HIV
Which NHL type? MALT lymphoma
Marginal Zone
Which NHL type? Cyclin D1 overexpression
Mantle Cell
Which NHL type? c-myc, starry sky appearance
Burkitt
Which NHL type? Most common
Diffuse Large B cell
Which NHL type? Curable
Diffuse Large B cell, Burkitt
Dx Chronic Lymphocytic Leukemia
Clonal >5,000 WBC increase in absence of cause
Which sign/pathology? Onset of facial flushing and inspiratory stridor with raising arms above head
Pemberton sign/SVC syndrome
Tx CNS metastases
Glucocorticoids
Electrolyte disturbances in Tumor Lysis Syndrome (4)
Hypocalcemia, hyperkalemia, hyperphosphatemia, hyperuricemia
Tx Hypercalcemia of Malignancy
NS/loop diuretics (+/- bisphosphonates)
Which diagnosis? flushing, diarrhea, wheezing, pellagra
Carcinoid syndrome
Which diagnosis? Palpitations, sweating, headache, confusion/seizures, hypoglycemia
Insulinoma
Lung Ca associated with PTHrP
SCC
Lung Ca associated with ACTH-secretion
SCLC
Ca associated with Lambert-Eaton
SCLC
Ca associated with DIC
APML
Syndrome/Ca associated with clubbing and arthritis
Hypertrophic Pulmonary Osteoarthropathy/Lung carcinoma