GI Flashcards
Which abdominal pathology? metabolic acidosis, thumb printing on XR
Mesenteric ischemia
Which abdominal pathology? non-tender palpable gallbladder
Pancreatic cancer
Tx IBS constipation
Fiber/SSRIs
Tx IBS diarrhea
loperamide, TCAs
Indications for EGD in dyspepsia
Age>55 or alarm features
Indications for H pylori testing in dyspepsis
Age under 55 without alarm features
Diagnosis of GERD
PPI trial or ambulatory esophageal reflux monitoring
Frequency of endoscopy in Barrett Esophagus
4-5 years (no dysplasia), 6-12 months (low-grade dysplasia)
Dx of H pylori
Histology or rapid urease
Tx H pylori
PPI + metronidazole + clarithromycin, PPI + amoxicillin + clarithromycin
Dx Wilson Disease
Serum ceruloplasmin
Dx Autoimmune hepatitis
Anti-smooth muscle antibodies
Dx hemochromatosis
Ferritin, transferrin, hepcidin
Dx primary biliary cholangitis
anti-mitochondrial antibodies
Which liver pathology? Low alkaline phosphatase
Wilson disease
Post-exposure ppx HAV
HAV Ig to household/daycare/sexual contacts
Post-exposure ppx HBV
HBV Ig for exposure
Screening for viral hepatitis (4)
Born 1945-1965, transfusion before 1992, IVDU, needle-stick
Extra-hepatic manifestations of HBV (3)
Glomerulonephritis, Cryoglobulinemia, polyarteritis nodosa
Extra-hepatic manifestations of HCV (3)
Glomerulonephritis, Cryoglobulinemia, Porphyria cutanea tarda
Which liver pathology? inclusions on PAS stain
alpha-1-antitrypsin deficiency
Tx autoimmune hepatitis
azathioprine, steroids
Tx Wilson disease
Tridentine or penicillamine, zinc (decreases absorption)
Dx PSC
endoscopic cholangiography
Cirrhosis: serum-ascites albumin gradient
> 1.1
Dx Spontaneous bacterial peritonitis
Ascites granulocyte count >250
Cirrhosis immunization:
HBV, HCV, PCV, flu
Tx ascites
spironolactone + lasix
Indication for albumin infusion in cirrhosis
> 5L ascitic fluid removed
Tx SBP
fluoroquinolone or TMP-SMX
Tx hepatorenal syndrome
decrease diuretics, norepinephrine/vasopressin (improves renal blood flow)
Tx hepatic encephalopathy (2)
Lactulose, rifaximin
Charcot Triad for Acute cholangitis
Fever, jaundice, RUQ pain
Reynold Pentad for Acute cholangitis
Fever, jaundice, RUQ pain, AMS, shock
Abx for acute cholecystitis
Metronidazole + (ampicillin-sulbactam or ciprofloxacin)
Tx PBC
UDCA
Systemic complications of pancreatitis (5)
hypocalcemia, hyperglycemia, ARDS, AKI, DIC
Tx pancreatic pseudocyst
Drainage ONLY IF symptomatic
Tx pancreatic abscess
Abx/drainage
Which diarrheal pathogen? Mayonnaise, potato salad
S. aureus
Which diarrheal pathogen? reheated rice
Bacillus cereus
Which diarrheal pathogen? shellfish
Vibro cholerae
Which diarrheal pathogen? raw milk
Campylobacter or Yersinia
Which diarrheal pathogens? associated with GBS
Campylobacter and Yersinia
Which diarrheal pathogens? Associated with HUS
EHEC, Shigella
Tx C difficile
Metronidazole > PO Vancomycin
Secretory diarrhea osmotic gap
under 50
Osmotic diarrhea osmotic gap
> 125
Diarrhea with pH<6
Carbohydrate malabsorption
Positive hydrogen breath test
Lactase deficiency
Which diagnosis? chronic relapsing-remitting watery diarrhea with normal colonoscopy and abnormal biopsy
Microscopic colitis
Which diagnosis? erythematous papulovesicles on extensor surfaces associated with diarrhea
Celiac disease
Which diagnosis? post-prandial flushing and tachycardia
Dumping syndrome (often w/hx of bariatric surgery)
Dx SIBO
quantitative culture of duodenal aspirate
Which diagnosis? hx of ileal resection, cholestasis
Bile acid malabsorption
Tx Bile acid malabsorption
cholestyramine
Which diagnosis? arthralgia, neurologic/ophthalmologic symptoms, LAD
Whipple Disease
Ophthalmologic emergencies in CD
Uveitis, Scleritis
Which diagnosis? Anti-saccharyomyces antibody
CD
Which diagnosis? diarrhea and positive p-ANCA
UC
Which diagnosis? Associated with erythema nodosum and pyoderma gangrenosum
UC
Which IBD medication? associated with interstitial nephritis
5-aminosalicylates (sulfasalazine, etc.)
Which IBD medication? antibiotics that may be used in CD
Metronidazole, ciprofloxacin
Which IBD medication? Immunomodulator used in CD associated with hepatotoxicity and pneumonitis
MTX
Which IBD medication? Immunomodulator in UC associated with nephrotoxicity and neurotoxicity
Cyclosporine
Which IBD medication? Immunomodulators associated with hepatotoxicity, leukopenia, lymphoma, and pancreatitis
6-MP, Azathioprine
Which IBD medication? used in CD refractory to anti-TNF therapy, associated with PML
Natalizumab
Which IBD medication? Associated with demyelination, heart failure, lymphoma
Anti-TNF
Which diagnosis? intermittent large volume upper GI bleeding
Dieulafoy lesion