RHABDOVIRIDAE (rabies Virus)

Question 1

Properties

Answer 1

ssRNA
Negative sense RNA Virus
Enveloped
Capsid - Bullet Shaped
NucleoCapside - Helical

Question 2

Pathogenesis

Answer 2

-GP of envelope binds to ACH-NICOTONIC RECEPTORS, entering the cell at MOTOR END PLATE. Replicates here.
-Virus enters the neuron, moves retrograde using dyenin protein. Virus finally reaches CNS.

Question 3

Symptoms

Answer 3

General: Fever, Malise, Paresthesia
Encephalopathy: Hydrophobia, foam production because of sever laryngeal spasm, Saliva production, sweat production.
Paralytic: Paralysis that moves upward.

Question 3

Symptoms

Answer 3

General: Fever, Malise, Paresthesia
Encephalopathy: Hydrophobia, foam production because of sever laryngeal spasm, Saliva production, sweat production.
Paralytic: Paralysis that moves upward.

Question 4

LD

Answer 4

Purkenji cell - Brain
Pyrimadal cells - Hypothalamus

They have Negri bodies. Stains strongly eosinophilic.

Question 5

Post-Exposure

Answer 5

Passive Immunization IgG
Killed Vaccine for Rabies.