EPSTEIN-BAR-VIRUS

Question 1

Properties

Answer 1

dsDNA
Enveloped

Question 2

Transmission

Answer 2

It’s transmiitted by Kiss AKA Kiss Disease..

Question 3

Disease

Answer 3

1. Infectious Mononucleosis

Question 4

Pathogenesis

Answer 4

EBV enters body, enters B-Cell via CD21 receptor though complement CD3, Latent there, travel throughout the lymph nodes and causes lymphadenopathy regionally and generalized.
EBV damages epithelial cells of Pharynx > Pharyngitis and enters lymphoid causes inflammation aka tonsillitis.
In spleen, CD8+ Cytotoxic cells will cause Reactive Lymphocytosis, Atypical cells AKA Downy cells.

.Causes SplenoMEGALY.

Question 5

Strept. Pneumoniae vs EBV

Answer 5

S.pnemoniae - children
EBV - Adults

When amoxycillin is given in EBV pt, there is maculopapular Rash.

Question 6

EBV causes Cancer!

Answer 6

1. Hodgkin’s Lymphoma(Reed Sternbag cells - Owl cells)
2. Burkitt’s Lymphoma(t8:14) in African.
3. Nasopharngeal Lymphoma in Asians.

Oral Hairy LeukoPlakia - In Immunocompromised.

Question 7

Laboratory Diagnosis

Answer 7

MonoSpot IgG test:
Heterophile Antibodies that are effective against’s sheeps RBC and cause them to agglutinate.