POLIOVIRUS Flashcards
1
Q
A
Positive sense ssRNA
Naked Virus
Acid-Stable and it’s R/T is fecal-oral.
2
Q
Pathogenesis
A
Proliferate in the tonsil and Peyer’s PATCHES of terminal illeum. Then, it will enter blood, muscle’s interstitium > Motor neurons > Moves RetroGrade through the motor neuron > Reaches Anterior Horn > Destroys alpha motor neurons. LMN lesion > Atrophied muscle. [PARALYSIS]
ASSYMETERIC paralysis in lower legs, Myalgias and respiratory paralysis.
CAUSES ASEPTIC MENINGITIS
3
Q
L/D
A
Stool Test / Nasopharngeal SWAB TEST
CSF: WBC increased or polio antigen.
4
Q
VACCINE
A
SALK - Killed Vaccine - IM
SABIN - Attenuated - ORAL
