CYTOMEGALOVIRUS

Question 1

-DNA VIRUS
-HerpesViridae
Latent in MonoNuclear Cells i.e B-cell, T-cell, Macrophahges.

When you become immunosupressed, it wakes up!

Question 1

CONGENITAL CMV: Most common fetal viral infection.
#1 cause of fetal viral infection and fetal mental retardation.
#1 cause of sensorineural hearing loss.
>BlueBerry Muffin Rash.
>SensoriNeural Deficiet
>HepatoSplenomegaly
>Ventricularmegaly, Peri-ventricular calcifications (Mental Retardation, Seizures).
>80% asymptomatic.
>2nd trimester
Hydrops Fetalis: Failed CVS, leading to generalized edema.

Question 2

Immunosuppressed, HIV, Transplant.
Transplant>CMV Pnemonia.
HIV: CD4<50, Pizza Pie Reinitis.
CMV esophagitis and Colitis.
CMV esophagitis: single, linear, deep.,

Question 3

LD: What is LD?

Answer 3

PCR
When it infects cell, there are owl-eye inclusion bodies.

Question 4

What is Tx?

Answer 4

CAN>GanCyclovir
If UL-97 mutation, Use Fast-Car-Net (FosaCarnet)