PARAMYXOVIRIDAE [Measles, Mumps, RSV, Parainfluenza Virus]

Question 1

Properties

Answer 1

ssRNA
Negative sense RNA
Enveloped virus

Vaccine: MMR [Mumps, Measles, Rubella], a live vaccine.
-Contraindicated in Females.

Question 2

MEASLES

Answer 2

CCCC = Cough, Conjunctivitis, Coryze, Koplick’s spot.
Fever - 104 F
MaculoPapular Rash starts from face and goes pheriperal.
Rash will become Confluent.

COMPLICATIONS:
1. Pneumonia.
2. SSPENSE [SSPE = SubAcute Sclerosing Pan Encephalitis]

VIRULENCE Factors:
Fusion Proteins - Form MNG cells in lymphoid.
Hemagglutinin.

Tx: No treatment, Vitamin A.

Question 3

MUMPS VIRUS

Answer 3

Lives in Parotid Salivary Gland - Parotitis.

Lives in Epididymus - Orchiditis
Meningitis [POM]

MMR vaccine covers it.

Virulence Factors: FP, HA, NA.

Question 4

RSV

Answer 4

Attaches to G-protein.
It causes pnemonia, Bronhiolotis. Most COMMON in infants.

Virulence Factors: Fusion Proteins.
Tx: Ribavirin.

Question 5

PARAINFLUENZA

Answer 5

Seal-Bark-Cough.
In Adults: Croup Disease.
-Inspiratory Stridor
-Laryngot

Question 6

PARAINFLUENZA

Answer 6

Seal-Bark-Cough.
In Adults: Croup Disease.
-Inspiratory Stridor
-Laryngotracheobronchitis