reversal of anticoagulant

Question 1

Heparin overdose may be reversed by?

Answer 1

protamine sulphate

only partially reverses the effect of LMWH!!!!

Question 2

x

Answer 2

x

Question 3

x

Answer 3

x

Question 4

x

Answer 4

x

Question 5

x

Answer 5

x

Question 6

warfarin with INR 5.0-8.0
No bleeding

Answer 6

Withhold 1 or 2 doses of warfarin
Reduce subsequent maintenance dose

Question 7

warfarin with INR 5.0-8.0
Minor bleeding

Answer 7

Give intravenous vitamin K 1-3mg
Restart when INR < 5.0

Question 8

warfarin reversal if INR 8 or more and no bleeding

Answer 8

Give oral vitamin K 1-5mg IV prep
Repeat dose of vitamin K if INR still too high after 24 hours
Restart warfarin when INR < 5.0

Question 9

warfarin reversal if INR 8 or more and minor bleeding

Answer 9

Give intravenous vitamin K 1-3mg
Repeat dose of vitamin K if INR still too high after 24 hours
Restart warfarin when INR < 5.0

Question 10

major bleeding rapid reversal of warfarin ?

Answer 10

iv vit k 5mg
prothrombin complex 1st or if not fresh frozen plasma

Question 11

reversal for dabigatran ?

Answer 11

Idarucizumab is a recently developed monoclonal antibody fragment which binds free and thrombin-bound dabigatran and rapidly neutralises its activity.

Prior to its development management of bleeding on dabigatran was limited to dialysis or supportive treatment with blood products, which was only partially effective

RIVAROXABAN and edoxaban