Quinolones Flashcards
1
Q
mechanism of action of quinolone?
A
antibiotics which work by inhibiting DNA synthesis and are bactericidal in nature
2
Q
examples of quinilones ?
A
ciprofloxacin
levofloxacin
3
Q
adverse effects of qinilones ?
A
lower seizure threshold in patients with epilepsy - do not give with seizures !!!
tendon damage (including rupture) - the risk is increased in patients also taking steroids
cartilage damage has been demonstrated in animal models and for this reason quinolones are generally avoided (but not necessarily contraindicated) in children
lengthens QT interval
4
Q
cipro/levofloxacillin safe to give in breast feeding ?
A
no
5
Q
in which deficiency do we avoid quinilones ?
A
G6PD
