Antiviral agents Flashcards
Mechanism of action of Aciclovir and Ganciclovir
inhibits the viral DNA polymerase
side effect of acicylovir ?
Crystalline nephropathy
side effect of gancicylovir ?
Myelosuppression/agranulocytosis
Mechanism of action of ribavarin
inhibits inosine monophosphate (IMP) dehydrogenase, interferes with the capping of viral mRNA
ribavarin side effects ?
haemolytic anemia
Mechanism of action Amantadine
Inhibits uncoating (M2 protein) of virus in cell. Also releases dopamine from nerve endings
side effects of amantidine ?
Confusion, ataxia, slurred speech
mechanism of action of zidovudine (AZT), didanosine, lamivudine, stavudine, zalcitabine
Nucleoside analogue reverse transcriptase inhibitors (NRTI)
mechanism of action of Oseltamivir
Inhibits neuraminidase