Antiviral agents Flashcards

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1
Q

Mechanism of action of Aciclovir and Ganciclovir

A

inhibits the viral DNA polymerase

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2
Q

side effect of acicylovir ?

A

Crystalline nephropathy

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3
Q

side effect of gancicylovir ?

A

Myelosuppression/agranulocytosis

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4
Q

Mechanism of action of ribavarin

A

inhibits inosine monophosphate (IMP) dehydrogenase, interferes with the capping of viral mRNA

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5
Q

ribavarin side effects ?

A

haemolytic anemia

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6
Q

Mechanism of action Amantadine

A

Inhibits uncoating (M2 protein) of virus in cell. Also releases dopamine from nerve endings

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7
Q

side effects of amantidine ?

A

Confusion, ataxia, slurred speech

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8
Q

mechanism of action of zidovudine (AZT), didanosine, lamivudine, stavudine, zalcitabine

A

Nucleoside analogue reverse transcriptase inhibitors (NRTI)

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9
Q

mechanism of action of Oseltamivir

A

Inhibits neuraminidase

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