Antifungals

Question 1

Drug class - AZOLE (Clotrimazole) mechanism of action ?

Answer 1

inhibits 14a demethylase which produces ergosterol

Question 2

adverse side effects of Azole ?

Answer 2

P450 INHIBITOR

LIVER TOXICITY

Question 3

drug mechanism of Amphotercin B ?

Answer 3

binds to ergosterol - forming transmembrane channel - leading to monovalent ION (Na / potassium / ) LEAKAGE

Question 4

side effects of amphotercin B

Answer 4

NEPHROTOXICITY

HYPOKALEMIA / HYPOMAGNESIA

Flu like symptoms

Question 5

Amphotercin B indication ?

Answer 5

systemic fungal infection

Question 6

Mechanism of action of terbinafine ?

Answer 6

inhibits squalene epoxidase

Question 7

indication for terbinafine ?

Answer 7

commonly used in oral form

fungal skin and nail infections - athlete foot

Question 8

mechanism of action of GRISEOFLUVIN ?

Answer 8

intercats with microtubules - disrupt mitotic spindle

Question 9

side effects of GRISEOFLUVIN ?

Answer 9

induces P450 system
teratogenic

Question 10

Mechanism of action of flucytosine ?

Answer 10

converted by cytosine deaminase to 5 - fluorocil - inhibiting thymidylate synthase and disrupts fungal protein synthesis

Question 11

side effects of flucytosine ?

Answer 11

vomiting

Question 12

mechanism of action of caspofungin ?

Answer 12

inhibit synthesis of beta glucan - major fungal wall component

Question 13

side effect of caspofungin?

Answer 13

flushing

Question 14

mechanism of action of nystatin ?

Answer 14

binds with ergosterol - forming transmembrane channel - leads to leakage of ions

Question 15

Indication NOTES WITH NYSTATIN ?

Answer 15

can be very toxic - can only be used topically - EG FOR ORAL THRUSH