respiratory viruses Flashcards
3 main resp viruses
influenza
adenovirus
rhinovirus
subfamily of
- influenza
- adenovirus
- rhinovirus
- orthomyxoviridae
- adenoviridae
- picornavirus
genome type of
- influenza
- adenovirus
- rhinovirus
- -ssRNA
- ds DNA
- +ssRNA
enveloped or non
- influenza
- adenovirus
- rhinovirus
- enveloped
- nonenveloped
- nonenveloped
most common influenza serotype
A
reservoir for type A influenza
animal
how is influenza identified
surface antigens HA and NA
what is the major determinant for ifluenza human-human transmission
HA
where does influenza trabscription and replication take place
nucleus
which protein is critical to influenza budding
NA
transmission of influenza
aerosols, large and small droplets
influ. incubation period
1-4 days
which influ. strains are currently circulating
H3N2 and H1N1
vaccine for influ?
yes, live attenuated
antiviral therapy for influ?
yes
blocks virus entry, inhibits M2 activity
characterization of adenovirys
by serotype, 2 and 5 most frequently studied
entry of adenovirus
thru coxsackie-adenovirus receptor (CAR)
what triggers adenovirus capsid disassembly
pH
what does E1A inactivate
pRb, causes s phase gene expression
what does E1B inactivate
p53, prevents apoptosis
acute respiratory disease
adenovirus
severe pneumonia
common in military personelle
vaccine available
what does rhinovirus frequently cause
mild UR infection
reservoir for rhinovirus
humans only
where does rhinovirus attach
ICAM-1 and VLDL receptor
