respiratory viruses Flashcards

1
Q

3 main resp viruses

A

influenza
adenovirus
rhinovirus

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2
Q

subfamily of

  1. influenza
  2. adenovirus
  3. rhinovirus
A
  1. orthomyxoviridae
  2. adenoviridae
  3. picornavirus
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3
Q

genome type of

  1. influenza
  2. adenovirus
  3. rhinovirus
A
  1. -ssRNA
  2. ds DNA
  3. +ssRNA
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4
Q

enveloped or non

  1. influenza
  2. adenovirus
  3. rhinovirus
A
  1. enveloped
  2. nonenveloped
  3. nonenveloped
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5
Q

most common influenza serotype

A

A

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6
Q

reservoir for type A influenza

A

animal

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7
Q

how is influenza identified

A

surface antigens HA and NA

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8
Q

what is the major determinant for ifluenza human-human transmission

A

HA

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9
Q

where does influenza trabscription and replication take place

A

nucleus

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10
Q

which protein is critical to influenza budding

A

NA

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11
Q

transmission of influenza

A

aerosols, large and small droplets

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12
Q

influ. incubation period

A

1-4 days

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13
Q

which influ. strains are currently circulating

A

H3N2 and H1N1

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14
Q

vaccine for influ?

A

yes, live attenuated

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15
Q

antiviral therapy for influ?

A

yes

blocks virus entry, inhibits M2 activity

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16
Q

characterization of adenovirys

A

by serotype, 2 and 5 most frequently studied

17
Q

entry of adenovirus

A

thru coxsackie-adenovirus receptor (CAR)

18
Q

what triggers adenovirus capsid disassembly

A

pH

19
Q

what does E1A inactivate

A

pRb, causes s phase gene expression

20
Q

what does E1B inactivate

A

p53, prevents apoptosis

21
Q

acute respiratory disease

A

adenovirus
severe pneumonia
common in military personelle
vaccine available

22
Q

what does rhinovirus frequently cause

A

mild UR infection

23
Q

reservoir for rhinovirus

A

humans only

24
Q

where does rhinovirus attach

A

ICAM-1 and VLDL receptor

25
Q

incubation per for rhinovirus

A

1-4 days

26
Q

rhinovirus vaccine and antivirals

A

no, no

27
Q

what is ebola virus

A

filovirus, enveloped, RNA genome