hepatitis virus Flashcards
what do hepatitis viruses specifically target and what do they infect
liver, hepatocytes
subfamily
- HAV
- HBV
- HCV
- HDV
- HEV
- picornaviridae
- hepadnaviridae
- flaviviridae
- deltaviridae
- calciviridae
genome
- HAV
- HBV
- HCV
- HDV
- HEV
- +ssRNA
- circ ds DNA
- +ssRNA
- -ssRNA
- +ssRNA
enveloped/non
- HAV
- HBV
- HCV
- HDV
- HEV
- non
- env
- env
- env
- non
transmission
- HAV
- HBV
- HCV
- HDV
- HEV
- fecal-oral, sex, parenteral
- sex, vertical, parenteral
- sex, vertical, parenteral
- sex, vertical, parenteral
- fecal-oral, sex, parenteral
which types of herpes virus are very rare in the US
HDV and HEV
can HBV be grown in culture
no
what is HBV template for transcription
cccDNA
incub per for HBV
30-180 days
recovery from HBV
3-4 months after jaundice
is HBV chronic?
in 5 % cases
vaccine for HBV
yes, need multiple innoculations
Tx for HBV
IFN alpha, nucleoside analogs (adefovir, lamivudine, tenofovir)
what is HDV and what does it require
a subviral agent that requires an active HBV infection
proteins in HCV
E1 and 2, C, other non structurals
where is the HCV genome passed
into the cytoplasm
is HCV milder or more severe than HBV
milder
HCV chronic infections?
80%
HCV tx, vaccine?
zepatier, no vaccine
common transmission of HAV
fecally contaminated food, water
incub per for HAV
15-40 days
HAV vaccine?
Havrix, vaqta
what is HEV similar to
HAV
who is most threatened by HEV
pregnant women
HEV vaccine?
no
