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Micro/Immuno II > Childhood diseases > Flashcards

Childhood diseases Flashcards

1
Q

virus families of

  1. measles
  2. respiratory syncytial virus
  3. VZV
  4. poliovirus
  5. rotavirus
A
  1. paramyxovirus
  2. paramyxovirus
  3. alphaherpesvirus
  4. picornavirus
  5. reoviridae
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2
Q

enveloped or nonenveloped?

  1. measles
  2. respiratory syncytial virus
  3. VZV
  4. poliovirus
  5. rotavirus
A
  1. enveloped
  2. enveloped
  3. enveloped
  4. non enveloped
  5. non enveloped
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3
Q

genome type?

  1. measles
  2. respiratory syncytial virus
  3. VZV
  4. poliovirus
  5. rotavirus
A
  1. -ssRNA
  2. -ssRNA
  3. dsDNA, large
  4. +ssRNA
  5. dsRNA, 11 segments
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4
Q

infection method?

  1. measles
  2. respiratory syncytial virus
  3. VZV
  4. poliovirus
  5. rotavirus
A
  1. via inhaling droplets
  2. via inhaling droplets, and fomites (only ciliated cells in RT)
  3. via inhalation of droplets
  4. via ingestion of material containing viruses (primary rep in peyers patches, secondary rep is major viremia)
  5. via ingestion of material containing viruses
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5
Q

incubation period?

  1. measles
  2. respiratory syncytial virus
  3. VZV
  4. poliovirus
  5. rotavirus
A
  1. 10-14 days
  2. 4-5 days (LRT symptoms 1-3 days after URT symptoms)
  3. 10-21 days
  5. 2 days
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6
Q

measles prevention

A
  • vaccine, live attenuated
  • vit A can reduce severity
  • no antivirals
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7
Q

poliovirus prevention

A
  • inf doesn’t yield life long immunity
  • vaccination (salk: killed, sabin: live attenuated)
  • no animal reservoir
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8
Q

rotavirus prevention

A
  • infant vaccines (Rota teq: 2, 4, 6 mos, Rotarix: 2, 4 mos)
  • no antivirals
  • wash hands
  • tx: oral rehydration
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9
Q

VZV prevention

A
  • vaccination, lifelong, live attenuated

- antivirals (Acyclovir) interferes with genome replication, but cannot eliminate latent, doesn’t prevent inf of cells

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10
Q

RSV prevention

A
  • Ribavirin: administered via inhalation
  • no vaccine
  • passive immunoprophylaxis (Palivizumab): targets F proteins
  • animal reservoir
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11
Q

location of replication?

  1. measles
  2. respiratory syncytial virus
  3. VZV
  4. poliovirus
  5. rotavirus
A
  1. in cell
  2. in cell (only in RT)
  3. in cell (active cells for replication, resting cells for latent infection (ex, neurons->shingles)
  4. in cell (creates pore in CM)
  5. in cell (membrane disruption)
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12
Q

when do measles symptoms arise

A

with second round virus replication in lymph nodes, tonsils, lungs, GI

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13
Q

rash associated with measles

A

virus/immune response to damaged epithelium /endothelium cells
-Koplik spots (on buccal mucosa)

pt is infectious 2-3 days before rash

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14
Q

recovery time for measles

A

20 days after infection

most deadly childhood disease

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15
Q

complications from measles

A

immune suppression (CD46 and SLAM receptors)
opportunistic infections
blindness (in vit A def kids)
ADEm and SSPE

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16
Q

lab diagnosis of measles

A

serology, ELISA, RT-PCR

17
Q

RSV recovery

A

7-12 days after symptom onset

18
Q

rash associated with VZV

A

1-2 days after symptoms (progress for 3-6 days)

19
Q

VZV recovery

A

2 weeks, mainly due to cell mediated immunity

20
Q

CNS involvement for poliovirus

A

in 1:200 pts
virus replicated in grey matter
ant horn damage: limb paralysis
medulla damage: resp paralysis

21
Q

virus shedding with rotavirus

A

weeks before symptom onset, days after recovery

22
Q

diagnosis of rotavirus

A

antigens in stool

Micro/Immuno II (10 decks)

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