neuro viruses

Question 1

neurological viruses

Answer 1

Rabies
west nile
eastern equine encephalitis (EEE)
venezuelan equine encephalitis (VEE)

Question 2

subfamilies, genomes, enveloped/non

1. Rabies
2. west nile
3. eastern equine encephalitis (EEE)
4. venezuelan equine encephalitis (VEE)

Answer 2

1. rhabdoviridae, -ssRNA, enveloped
2. flaviviridae, +ssRNA, enveloped
3. togaviridae, +ssRNA, enveloped
4. togaviridae, +ssRNA, enveloped

Question 3

how are some togaviridae and flaviruses transmitted

Answer 3

thru arthropod vectors (mosquitos and ticks)

Question 4

neuro viruses reservoirs

Answer 4

birds, small mammals

Question 5

what does transmission require

Answer 5

replication in vector

Question 6

incub per for EEE and VEE

Answer 6

4-10 days

Question 7

proteins in EEE and VEE

Answer 7

E 1 and 2
capsid protein
non structurals

Question 8

how is EEE and VEE introduced

Answer 8

thru infected arthropod bite (infect cells locally or carried to LN by langerhans cells)

Question 9

EEE and VEE vaccine? tx?

Answer 9

TC-83, live attenuated, no tx (mosquite control and repellant)

Question 10

incub per for WNV

Answer 10

2-14 days, most people have asymptomatic infection

illness with 20% of infections lasting 3-6 days

Question 11

WNV vaccine? prevention?

Answer 11

no, no

mosquito control and repellant

Question 12

main transmitters of WNV

Answer 12

culex mosquitos

Question 13

zika virus

Answer 13

flavivirus
enveloped
RNA genome
lifelong inf in Aedes mosquuitos

Question 14

complications of zika fever

Answer 14

guillain barre

newborn microcephaly

Question 15

rabies virus

Answer 15

broad tropism

only replicate in cytoplasm

Question 16

what triggers genome replication in rabies virus

Answer 16

binding of nucleoprotein to RNA

Question 17

transmission of rabies virus

Answer 17

bite of infected animal

Question 18

incub per for rabies virus

Answer 18

1-3 months