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systemic pharm > respiratory therapy pt 2 > Flashcards

respiratory therapy pt 2 Flashcards

1
Q

fluticasone moa

A
  • Acts through classic steroid pathway inhibiting arachidonic acid-based eicosanoid production
  • Steroidal Anti-Inflammatory
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2
Q

fluticasone adverse effects

A

ADVERSE EFFECTS
Common: headache, cough, pyrexia, epistaxis, nasopharyngitis
SEVERE ADVERSE EFFECTS
Hormonal: adrenal suppression, hypercorticism, pediatric growth suppression
Nasal: nasal/oral candidiasis, nasal ulcer or septal perforation
Ocular: cataracts, glaucoma, elevated IOP

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3
Q

salmeterol moa

A

Mechanism of Action
A chemical analog of Albuterol having a lipophilic side chain that enhances duration of action; like Albuterol, this β2 Agonist produces relaxation of airway smooth muscle
CLINICAL PHARMACOLOGY
Βronchodilator

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4
Q

SALMETEROL
ADVERSE EFFECTS
SEVERE ADVERSE EFFECTS

A

SALMETEROL
ADVERSE EFFECTS
Common: headache, nasal congestion, rhinitis, bronchitis, urticaria, tachycardia
SEVERE ADVERSE EFFECTS
Hypersensitivity: anaphylaxis, angioedema
Respiratory: bronchospasm (paradoxical), asthma exacerbation/death
CV: arrhythmia, HTN

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5
Q

Advair diskus indication

A

INDICATION
Asthma / COPD Maintenance
DOSING [100/50, 250/50, 500/50 μg]
1 puff bid

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6
Q

ADVAIR DISKUS

DRUG INTERACTIONS

A

ADVAIR DISKUS
DRUG INTERACTIONS
Β-Blockers (Additive)
Cyclosporine, Azole antifungals (Impaired Metabolism)
Macrolides, Amphotericins, CAIs, Steroids (Hypokalemia)
Macrolides, Sympathomimetics (QT Prolongation)

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7
Q

MOMETASONE

INDICATION

A 
MOMETASONE
INDICATION
Allergic Rhinitis, Nasal Polyp Therapy
DOSING [50 μg/spray]
2 sprays qd-bid
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8
Q

MOMETASONE
CLINICAL PHARMACOLOGY
Mechanism of Action

A 
MOMETASONE
CLINICAL PHARMACOLOGY
Corticosteroid Nasal Spray
Mechanism of Action
Inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
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9
Q

MOMETASONE

ADVERSE EFFECTS

A

MOMETASONE
ADVERSE EFFECTS
Common: Headache, viral infection, epistaxis, conjunctivitis
NOTABLE ADVERSE EFFECTS
Sinus: Septal perforation, ulcer, candidiasis
Ocular: Elevated IOP, glaucoma

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10
Q

MOMETASONE

DRUG INTERACTIONS

A

MOMETASONE
DRUG INTERACTIONS
NONE

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11
Q

MOMETASONE

CONTRAINDICATIONS/CAUTIONS

A 
MOMETASONE
CONTRAINDICATIONS/CAUTIONS
Nasal septal ulcer, recurrent epistaxis
TB infection
Ocular HSV infection, glaucoma, cataracts, vision changes
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12
Q

Montelukast [Singulair®]
Albuterol [ProAir HFA®]
Fluticasone/Salmeterol [Advair Diskus®]
Mometasone [Nasonex®]

A

respiratory therapies

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13
Q

-sone

A

respiratory drugs

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14
Q

inhaled steroids are the first choice in what types of pt?

A

pts with persistent/severe asthma (routinely)

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15
Q

90% of asthma therapy is what

A

swallowed

90% swallowed –> absorption in GI –> first pass in liver–> systemic side effect

10% of it actually reaches the lungs

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16
Q

mouth rinsing is responsible for what?

A

loss of asthma drug

17
Q

creates unusual taste sensation

A

steroid in asthma therapy

18
Q

immunosuppressant property of steroid when inhaled can cause what?

A

potential to dev of microbial growth in oral cavity (gingivitis)

19
Q

what drug creates unusual taste sensation

A

steroid in asthma therapy

20
Q

immunosuppressant property of steroid when inhaled can cause what?

A

potential to dev of microbial growth in oral cavity (gingivitis)

21
Q

steroids inhibit what?

A

healing

22
Q

analog of albuterol

A

salmeterol

*lipophilic side chain

23
Q 
FLUTICASONE
CLINICAL PHARMACOLOGY
Steroidal Anti-Inflammatory
Mechanism of Action
Acts through classic steroid pathway inhibiting arachidonic acid-based eicosanoid production
A

FLUTICASONE

CLINICAL PHARMACOLOGY

24
Q

FLUTICASONE
ADVERSE EFFECTS
Common: headache, cough, pyrexia, epistaxis, nasopharyngitis
SEVERE ADVERSE EFFECTS
Hormonal: adrenal suppression, hypercorticism, pediatric growth suppression
Nasal: nasal/oral candidiasis, nasal ulcer or septal perforation
Ocular: cataracts, glaucoma, elevated IOP

A

FLUTICASONE

ADVERSE EFFECTS

25
Q 
SALMETEROL
CLINICAL PHARMACOLOGY
Βronchodilator
Mechanism of Action
A chemical analog of Albuterol having a lipophilic side chain that enhances duration of action; like Albuterol, this β2 Agonist produces relaxation of airway smooth muscle
A

SALMETEROL

CLINICAL PHARMACOLOGY

26
Q 
SALMETEROL
CLINICAL PHARMACOLOGY
Βronchodilator
Mechanism of Action
A chemical analog of Albuterol having a lipophilic side chain that enhances duration of action; like Albuterol, this β2 Agonist produces relaxation of airway smooth muscle
A

SALMETEROL

CLINICAL PHARMACOLOGY

27
Q

SALMETEROL
ADVERSE EFFECTS
Common: headache, nasal congestion, rhinitis, bronchitis, urticaria, tachycardia
SEVERE ADVERSE EFFECTS
Hypersensitivity: anaphylaxis, angioedema
Respiratory: bronchospasm (paradoxical), asthma exacerbation/death
CV: arrhythmia, HTN

A

SALMETEROL

ADVERSE EFFECTS

28
Q 
ADVAIR DISKUS
INDICATION
Asthma / COPD Maintenance
DOSING [100/50, 250/50, 500/50 μg]
1 puff bid
A

ADVAIR DISKUS

INDICATION

29
Q

ADVAIR DISKUS
DRUG INTERACTIONS
Β-Blockers (Additive)
Cyclosporine, Azole antifungals (Impaired Metabolism)
Macrolides, Amphotericins, CAIs, Steroids (Hypokalemia)
Macrolides, Sympathomimetics (QT Prolongation)

A

ADVAIR DISKUS

DRUG INTERACTIONS

30
Q 
MOMETASONE
INDICATION
Allergic Rhinitis, Nasal Polyp Therapy
DOSING [50 μg/spray]
2 sprays qd-bid
A

MOMETASONE

INDICATION

systemic pharm (16 decks)

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