Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

systemic pharm > analgesics > Flashcards

analgesics Flashcards

1
Q

NSAIDS AND OPIODS

A

2 types of analgesics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

important inflammatory mediators that are produced locally and dont circulate to any significant degree

A

prostaglandin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

sensitizes nerve endings to the action of bradykinin, histamine, and other chemical mediators

A

PGE2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

act by inhibiting the synthesis of prostaglandins

A

NSAID function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

binds to cyclooxygenase, irreversible –> cant be reproduced
*if NSAID binds to cyclooxygenase –> platelet does not work

prostaglandin 2 synthase –> acts at final inflammatory level

platelets are fragments of thrombocytes (anuclear) –> no capacity to regenerate
SSRI –> will interfere with seratonin pathway –> inhibits platelet aggregation

thromboxane A 2 –> mediator of platelet aggregation

A

NSAID random facts about blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

acetaminophen (tylenol)
ibuprofen (advil)
celecoxib (celebrex)

A

3 popular nsaid drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

acetaminophen (tylenol)
ibuprofen (advil)
celecoxib (celebrex)

A

3 popular nsaid drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

indication: pain (mild), fever
dose: 325-1000 mg; 1 tab q4-6h

A

acetaminophen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

– Act by inhibiting COX and enhancing 5-HT release (attenuates pain mediator generaIon)
– Regulates body temperature by acIng centrally at the hypothalamus; PG synthetase inhibition

A

acetaminophen moa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

– Anti-inflammatory
– Anti-platelet
– Anti-pyretic
– Central

A

ASA (aspirin) distinctions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q 
No inflammatory control i.e. not an NSAID
– No platelet inhibition
– Anti-pyretic
– Central pain relief only
– No GI effects – Safe in pregnancy
A

acetaminophen distinctions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ADVERSE EFFECTS
• Common: nausea, rash, headache
SERIOUS ADVERSE EFFECTS
• Hepatic: acute hepatotoxicity usually w/ doses >4g/d
• Renal: acute renal tubular necrosis, chronic analgesic nephropathy

A

acetaminophen effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

NT that we see as a target NT in nausea pathway

A

seratonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

why do people over use acetaminophen?

A

acute hepatotoxicity –> causes death

*therefore dont use with people who have liver disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

why do people over use acetaminophen?

A

acute hepatotoxicity –> causes death

*therefore dont use with people who have liver disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

classic sign of liver disease

A

jaundice, yellow sclera

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q
  • Acetaminophen/Antihistaminic Combos (additive hepatotoxicity)
  • ASA (additive nephropathy)
  • Lidocaine Topical (additive methemoglobinemia)
A

acetaminophen drug interactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

• INDICATION
• Mild to Moderate Pain, Primary
Dysmenorrhea, Fever
• DOSING [100-800mg] • 400mg q4-6h

A

ibuprofen indication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

• CLINICAL PHARMACOLOGY – NSAID Analgesic
• Mechanism of Action
– Inhibits COX, reducing PG and TXA2 synthesis

A

ibuprofen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

ADVERSE EFFECTS
• Common: headache, fluid retention, ecchymosis, photosensitivity
NOTABLE ADVERSE EFFECTS
• Neuro: tinnitus
• Renal: acute renal tubular necrosis, chronic analgesic nephropathy

A

ibuprofen adverse effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

• DRUG INTERACTIONS
• ASA NSAIDs, Acetaminophen (addiIve
hemorrhagic risk)
• Acetaminophen, Cyclosporine (addiIve nephrotoxicity)

A

ibuprofen drug interactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

• INDICATION
• ArthriIs, Ankylosing SpondyliIs,
Dysmenorrhea, Acute Pain
• DOSING [50-400mg] • 200 mg qd-bid

A

celecoxib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

• INDICATION
• ArthriIs, Ankylosing SpondyliIs,
Dysmenorrhea, Acute Pain
• DOSING [50-400mg] • 200 mg qd-bid

A

celecoxib indication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

• INDICATION
• ArthriIs, Ankylosing SpondyliIs,
Dysmenorrhea, Acute Pain
• DOSING [50-400mg] • 200 mg qd-bid

A

celecoxib indication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

• INDICATION
• ArthriIs, Ankylosing SpondyliIs,
Dysmenorrhea, Acute Pain
• DOSING [50-400mg] • 200 mg qd-bid

A

celecoxib indication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

• CLINICAL PHARMACOLOGY – NSAID Analgesic
• Mechanism of AcIon
– SelecIvely inhibits COX-2 and reduces PG synthesis

A

celecoxib moa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q 
ADVERSE EFFECTS
•  Common: headache
BLACK BOX WARNINGS
•  CV: Stroke, CHF, MI
•  GI: Bleed, ulceraIon/perforaIon
A

celecoxib adverse effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q
  • NSAIDs (esp Ketorolac), Corticosteroids (hemorrhage)

* Azoles (impaired metabolism)

A

celecoxib drug interactions

29
Q

• CONTRAINDICATIONS/CAUTIONS • Sulfonamide allergy

A

contraindication of celecoxib

30
Q

Alleviation of pain depends on the specific type of pain, nociceptive (ache) or neurogenic (tingle) pain
• Neurogenic pain responds best to anticonvulsants or antidepressants
• Opioids are natural or synthetic (heroin) compounds that produce morphine - like effects

A

opiod fun facts

31
Q

drugs For severe or chronic malignant (worst and worst with progression of disease) or
nonmalignant pain

A

opiods

32
Q
  • Hydrocodone/Acetaminophen [Vicodin®]
  • Oxycodone [Oxycontin®]
  • Meperidine [Demerol®]
  • Fentanyl [Duragesic®]
A

4 kinds of opiods

33
Q
  • Hydrocodone/Acetaminophen [Vicodin®]
  • Oxycodone [Oxycontin®]
  • Meperidine [Demerol®]
  • Fentanyl [Duragesic®]
A

4 kinds of opioids

34
Q

ADVERSE EFFECTS
• Common: lightheadedness, dizziness, sedation, miosis [no tolerance], pruritus and flushing (histamine release [little tolerance])

A

hydrocodone adverse effects

35
Q

suppresses hypothalamus –> reducing outputs from pit gland –> stimulates prolactin and growth hormone release

A

hydrocodone (opioids in general)

36
Q

NOTABLE ADVERSE EFFECTS
• CNS:drowsiness ((tolerance in about 1 (wk), mood changes quick tolerance;elevated intra cranial pressure,enhanced w/ head injury
• CV:bradycardia/tachycardia; orthostatic hypotension
• Respiratory:dose related respiratory
depression at brainstem respiratory center

A

Hydrocodone notable adverse effects

37
Q

which drug should not be given when pt comes in with car accident involving blunt trauma?

A

opioid (hydrocodone)

38
Q

respiratory suppression leading to death

A

seen in drug overdose in hydrocodone

39
Q

pt is complaining of itchy eyes (allergic conj?) - how do we distinguish this vs. opioid use?

A

opioid is taken systemically so flushing should occur throughout body

40
Q

pt is complaining of itchy eyes (allergic conj?) - how do we distinguish this vs. opioid use?

A

opioid is taken systemically so flushing should occur throughout body

41
Q

classic systemic side effect to hydrocodone

A

constipation

42
Q
  • DRUG INTERACTIONS

* Carbonic Anhydrase Inhibitors (CAIs)

A

acetaminophen

43
Q

CONTRAINDICATIONS/CAUTIONS

• Mydriatic Procedures (antagonized)

A

hydrocodone/acetaminophen

44
Q

• CLINICALPHARMACOLOGY– Central Acting Synthetic Opioid Analgesic
• Mechanism of Action
Agonist at mu receptors and weak inhibitor of NE/5VHT reuptake;mu agonist effect is greater with active metabolite

A

tramadol moa

45
Q

CONTRAINDICATIONS/CAUTIONS

• Mydriatic Procedures (antagonized)

A

hydrocodone????

46
Q

• CLINICALPHARMACOLOGY– Central Acting Synthetic Opioid Analgesic
• Mechanism of Action
Agonist at mu receptors and weak inhibitor of NE/5VHT reuptake;mu agonist effect is greater with active metabolite

A

tramadol

47
Q
  • INDICATION
  • Moderate–(Moderate/Severe Pain
  • DOSING([50-300mg]
  • 50-100mg q4-6h
A

tramadol indication

48
Q

analgesic

A

tramadol

49
Q

drug moa resembling snri

A

tramadol

50
Q

ADVERSE EFFECTS
• Common:headache,pruritus,flushing
NOTABLE ADVERSE EFFECTS
• Respiratory:bronchospasm, respiratory depression
• CNS:Serotoninsyndrome, seizures, suicidal ideation
• CVS:Orthostatic hypotension

A

tramadol adverse effects

51
Q

unlike most opioids, miosis is not listed as an adverse effect of which drug?

A

tramadol

52
Q

if you have a pt with respiratory complication, which drug could worsen it?

A

tramadol

53
Q

orthostatic hypotension is seen in which two drugs?

A

tramadol and hydrocodone

54
Q

DRUG INTERACTIONS
• Anticholinergic additive constipation/ paralytic(ileus)
• Sedating Classic Antihistaminics ((additive CNS depression)
• Azole Antifungals (impaired metabolism)

A

tramadol drug interactions

55
Q
  • INDICATION(
  • Moderate(–(Moderate/Severe(Pain
  • DOSING [50V300mg]
  • 50V100mg q4-6h
A

tramadol indication

56
Q

ADVERSE EFFECTS
• Common:headache, pruritus, flushing
NOTABLE ADVERSE EFFECTS
• Respiratory:bronchospasm, respiratory depression
• CNS:Serotonin syndrome, seizures, suicidal ideation
• CVS:Orthostatic hypotension

A

tramadol adverse effects

57
Q

orthostatic hypotension is seen in which two drugs?

A

tramadol and hydrocodone

58
Q

DRUG INTERACTIONS
• Anticholinergic additive constipation/ paralytic(ileus)
• Sedating Classic Antihistaminics ((additive CNS depression)
• Azole Antifungals (impaired metabolism)

A

tramadol drug interactions

59
Q

which drugs are contraindicated for sulfonamide allergies/hypersensitivities?

A

celecoxib, furosemide, and HCTZ

60
Q

is there tolerance to opioids over time?

A

no

61
Q

do opiods cause miosis or mydriasis?

A

miosis

62
Q

what FDA schedule are opioids?

A

2

63
Q

is there tolerance to opioids over time regarding miosis?

A

no

64
Q

what FDA schedule are opioids?

A

2

65
Q

which two types of drugs can cause seratonin syndrome and suicidal ideation?

A

tramadol and antidepressants

66
Q

which two types of drugs can cause seratonin syndrome and suicidal ideation?

A

tramadol and antidepressants

67
Q

pruritis is a very common side effect to which drug?

A

tramadol

68
Q

pruritis is a very common side effect to which drug?

A

tramadol

69
Q

no ocular therapeutics involved

A

montelukast and levodopa + carbidopa

systemic pharm (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions