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systemic pharm > drug mechanisms and indications (midterm 1) > Flashcards

drug mechanisms and indications (midterm 1) Flashcards

1
Q

Angiotensin-converting enzyme (ACE aka kininase) inhibitor; suppresses RAA system and simultaneously inhibits bradykinin degradation

A

lisinopril moa

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2
Q

Indication for lisinopril

A

HTN
CHF
ACUTE MI

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3
Q

VALSARTAN

A

Selective antagonist of Angiotensin II receptor

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4
Q

INDICATION FOR VALSARTAN

A

HTN
CHF
POST MI

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5
Q

amlodipine moa

A

Inhibits trans membrane Ca++ current into vascular smooth muscle&raquo_space; cardiac muscle

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6
Q

indication for amlodipine

A

HTN

CAD

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7
Q

Antagonizes peripheral alpha-1 adrenergic receptors

A

TERAZOSIN MOA

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8
Q

indication for terazosin

A

HTN

BPH

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9
Q
  • Selective competitive antagonism of β1 receptors reducing systolic BP and CO via negative inotropic (beats soft) and chronotropic (beats slow)effects
  • Central acting inhibition of sympathetic outflow
  • Suppression of renin activity
A

metoprolol

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10
Q

indication for metoprolol

A

HTN
angina pectoris
POST MI

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11
Q

Inhibits reabsorption of NaCl at proximal/distal convoluted tubule & loop of Henle

Anti-HTN: High Ceiling/Loop Diuretic (Ca2+ and K+ depleting)

A

FUROSEMIDE MOA

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12
Q

indication of furosemide

A

HTN*,
Acute Pulomo-nary Edema (respiratory distress),
Hyper-calcemia

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13
Q

Inhibits reabsoprtion of NaCl at distal convoluted tubule

Anti-HTN: Thiazide Diuretic (Ca2+ sparing)

A

hctz moa

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14
Q

indication for hctz

A

HTN, Peripheral Edema, CHF, Osteo-porosis

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15
Q

Antagonizes aldosterone receptors in distal convoluted tubule resulting in sodium/water loss and potassium retention

Anti-HTN: Potassium sparing diuretics (drugs that do not promote the secretion of potassium into the urine)

A

spironolactone

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16
Q

spironolactone indication

A

HTN, CHF, Hyperaldosteronism, Hypo-kalemia

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17
Q

Stimulates central and spinal alpha-2 adrenergic receptors (pre-synaptic and post-junctional)
Anti-HTN: Central-Acting Alpha Agonist
-Analgesic

A

clonidine

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18
Q

clonidine indication

A

htn

severe cancer related pain

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19
Q

Directly dilates peripheral vessels via hyperpolarization of vascular smooth muscle which thus inhibits Ca2+ influx (depolarization)

A

moa of hydralazine

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20
Q

indication of hydralazine

A

htn
chf
hypertensive crisis

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21
Q

Stimulates CNS through a sympathomimetic mechanism involving the enhanced release and reduced reuptake of NE and dopamine

A

moa of amphetamine

22
Q

indication for amphetamine

A

ADHD

NARCOLEPSY

23
Q

Selective serotonin reuptake inhibitor (SSRI)

A

ESCITALOPRAM

24
Q

indication for escitalopram

A

Major Depressive Disorder,

Generalized Anxiety Disorder

25
Q

Selective Serotonin & NE reuptake inhibitor (SNRI)

A

duloxetine

26
Q

indication for duloxetine

A

Depression, Anxiety, Neuropathic Pain (DM), Fibromyalgia

27
Q

Selective Serotonin (5-HT) Reuptake Inhibitor (SSRI); Adrenergic alpha-1 blocker & 5-HT2A/C blocker

A

trazadone

28
Q

indication for trazadone

A

major depressive disorder

insomnia

29
Q

Antagonizes D2 receptors & 5-HT2 receptors

Ancillary effects may arise from antagonism of H1 and alpha-1

A

quetiapine moa

30
Q

indication for quetiapine

A

schizophrenia

31
Q

Indirect (central) acting; reversibly binds to and inactivates acetylcholinesterase

A

donepezil

32
Q

indication for donepezil

A

alzheimer

dementia

33
Q
  • Levodopa is a dopamine (DA) precursor that, unlike DA, crosses the BBB to enhance DA synthesis in substantia nigra
  • Carbidopa is an inhibitor of dopa decarboxylase; the latter degrades levodopa to dopa
A

antiparksinson therapy

34
Q

Selectively binds to GABAA-BZD receptors, thereby enhancing GABA effects

A

moa for alprazolam

35
Q

what type of benzodiazepine is alprazolam?

A

intermediate acting

36
Q

indication for alprazolam

A

anxiety

panic disorder

37
Q

Selectively binds to GABAA-BZD receptors, thereby enhancing GABA effects

A

zolpidem

38
Q

indication for zolpidem

A

insomnia

39
Q

Selectivity binds to airway cysteinyl leukotriene receptors blocking their stimulation by their endogenous ligands (LTC4, LTD4, LTE4) which are released by mast cells and eosinophils

A

moa for montelukast

40
Q

indication for montelukast

A

asthma
bronchospasm
allergic rhinitis

41
Q

Selectively stimulates β2 adrenergic receptors causing relaxation in airway smooth muscle

A

albuterol moa

42
Q

indication for albuterol

A

asthma
bronchospasm
copd

43
Q

Acts through classic steroid pathway inhibiting arachidonic acid-based eicosanoid production

A

fluticasone

44
Q

indication for fluticasone

A

asthma

copd maintenance

45
Q

steroidal antiinflammatory for respiratory drugs

A

fluticasone

46
Q

A chemical analog of Albuterol having a lipophilic side chain that enhances duration of action; like Albuterol, this β2 Agonist produces relaxation of airway smooth muscle

A

moa of salmeterol

47
Q

bronchodilator for resp therapy

A

salmetarol

48
Q

indication for salmeterol

A

asthma

COPD maintenance

49
Q

Inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects

A

MOMETASONE

50
Q

indication for momemtazone

A

allergic rhinitis

nasal polyp therapy

systemic pharm (16 decks)

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