GI therapy Flashcards
4 common medical conditions affecting GIT
- gastric peptic ulcers
- nsaid toxicity
- diarrhea
- constipation
2 types of gastric/peptic ulcers
Excessive hydrochloric acid secretion
Helicobacter pylori infection
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Excessive hydrochloric acid secretion
3 types of GIT for excessive HCL secretion
Proton Pump Inhibitors (PPIs)
H2 Receptor Blockers
Antacids
4 types of proton pump inhibitors
Esomeprazole [Nexium®]
Omeprazole [Prilosec®]
Lansoprazole [Prevacid®]
Pantoprazole [Protonix®
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esomeprazole
indication for esomeprazole
INDICATION
GERD, Gastric Ulcer Prophylaxis (NSAID-associated), Hypersecretory Disorders, H. pylori infection
DOSING [20-40mg tab vs oral suspension vs IV]
1 tab qd
moa of esomeprazole
CLINICAL PHARMACOLOGY
Proton Pump Inhibitor (PPI)
Mechanism of Action
Irreversibly inhibits gastric parietal cell H+-K+-ATPase, thereby inhibiting gastric acid secretion
adverse effects of esomeprazole
ADVERSE EFFECTS
Common: headache, constipation or diarrhea, xerostomia, flatulence
SERIOUS ADVERSE EFFECTS
SJS, TEN
esomeprazole drug interaction
Impaired absorption of Azole Antifungals and Certain Antiviral Agents
Azole Antifungals (Impaired metabolism)
CAIs (Exacerbation of Hypomagnesemia)
4 types of H2 receptor blockers
Cimetidine [Tagamet®]
Ranitidine [Zantac®]
Famotidine [Pepcid®]
Nizatidine [Axid®]
cimetidine indication
INDICATION
GERD, Peptic Ulcer, Dyspepsia
DOSING [200mg]
1-2 tab PO qd
cimetidine moa
CLINICAL PHARMACOLOGY
H2 Blockers
Mechanism of Action
Selective antagonism of gastric parietal cell H2 receptors
ADVERSE EFFECTS Common Headache, dizziness SERIOUS ADVERSE EFFECTS Food and drug allergies Blood dyscrasias Psychosis, depression Reversible impotence, gynecomastia
cimetidine adverse effects
cimetidine drug interactions
Impaired absorption of Azole Antifungals and Certain Antiviral Agents
Impaired metabolism of caffeine affecting NSAIDs w/ Caffeine
Impaired metabolism of Cyclosporine
