Respiratory System Flashcards
What’s the outcome of nasal planum tumour in dogs treated with surgery?
Generally good, recurrence is possible especially with incomplete margins. Bigger cut (incisivectomy/ maxillectomy) +/- RT may improve outcome.
What’s the outcome of nasal planum SCC in cats treated with surgery?
Very good, 10% recurrence (62 cats).
- median DFI = 594 days (1.6y; single); 426 days (multiple SCC)
- MST = 673 days (1.8y); 530 days (~1.5y)
What’s the outcome of surgical curettage and diathermy for feline SCC of the nasal planum?
Generally not advised as most SCC are invasive, but one study only had 6% recurrence within 18m
What’s the outcome of RT for canine nasal planum SCC?
disappointing, all recur within 2-3 months
What’s the outcome of RT for feline nasal planum SCC?
Orthovoltage: PFS 60%
Megavoltage: DFI 361-916 days; MST 902 (~2.5y)
Accelerated RT with protons: PFS 64%, MST 946 (2.6y)
What’s the outcome of Sr90 for feline nasal planum SCC?
CR: 80%
Recurrence: 20%
New lesions: 33%
PFS @ 3y = 82%
MST = 3076 days (8.4y)
What’s the outcome of intralesional carboplatin for feline nasal planum SCC?
CR: 73%
local recurrence rate: 30%
PFS: 16 months
What’s the outcome of electrochemotherapy for feline nasal planum SCC?
CR: 75-86%
DFI: 7-36 months
What’s the outcome of photodynamic therapy for feline nasal planum SCC?
ORR: 96%, with 85% CR
at 38 months, 45% had no recurrence (but 50% of those in CR recurred by 5 months)
Describe the staging system for sinonasal tumours.
What’s the likelihood of metastatic LN on presentation for canine sinonasal tumours?
10-20%
What’s the likelihood of distant metastasis on presentation for canine sinonasal tumours?
2-10% pulmonary metastasis.
one study that did thoracic and AUS, had 4/25 dogs with significant alteration to treatment due to concurrent illness
What are 2 rare paraneoplastic syndromes presentation for canine sinonasal tumours that can be noted on bloodwork?
erythrocytosis
hypercalcemia
What’s the outcome of canine nasal carcinoma without treatment?
MST 95 days
MST 88 days vs 224 days (with or without epistaxis)
What’s the general outcome of canine sinonasal tumours treated with CFRT?
MST 8 - 19.7 months
- 1 year survival 43-68%
- 2 year survival 11-44%
What treatment modalities for canine sinonasal tumours had the longest reported MST?
4.2Gy x 10fx followed by surgical exenteration. MST = 47 months! Has increased incidence of last side effects –> rhinits, osteomyelitis, fistula
another one with 3Gy x 18fx had MST of 15m but no long term side effects
What was the outcome of using gemcitabine as a radiation sensitizer for canine sinonasal tumours?
there was significant neutropenia and severe local tissue complications… not worth it.
not clear if radiation sensitizer will improve outcome
What’s the general outcome for canine sinonasal tumours treated with SRT?
MST: 8.5-19.5 months
in a large study with 182 dogs (Hiroto 2023) MST = 441 days (~15m), 3% with skin/oral cavity AE, 61% possible chronic rhinitis post RT
How does tumour stage influence canine sinonasal tumours treated with SRT?
it doesn’t! Stage is not prognostic in SRT settings
What’s the outcome of canine sinonasal tumours treated with PRT?
- 66-100% dogs will have improvement of clinical signs
- median duration of clinical improvement 4-10 months
- MST: 5-17 months
What’s the outcome of chemotherapy with canine sinonasal tumours?
favorable, but the case numbers are small.
- Cisplatin: RR= 27%, MST = 5m
- Doxorubicin, carboplatin, and piroxicam: MST = 7m
all dogs had improvement in clinical signs and tolerated the chemo well, some achieved CR.
What’s the outcome of electrochemotherapy for canine sinonasal tumours?
RR: 90%
MST = 16.9 months
How does the stage of the tumour influence palliative RT for canine sinonasal tumours?
Stage I is correlated with longer survival time
What are the reported times of canine nasal OSA treated with RT/SRT?
RT: MST = 624 (21 months)
SRT: MST = 3 months…
so it’s unclear how nasal OSA responses to RT