Respiratory Histology Flashcards

1
Q

Hilum of lung

A

Medium indentation in the trachea in which the arteries veins and lymphatics, and bronchi go through

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2
Q

Root of the lung

A

Those first two bronchis from the trachea

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3
Q

Two anatomical Division of the lung

A

The upper Respiratory Airways and theLower respiratory Airways

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4
Q

Three parts of the respiratory system

A

lungs and respiratory portion
the ventalation mechanism (ie the rib and muscle)
and the air passages

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5
Q

Two functional regions of the lungs

A

Conducting portion and the respiratory portion

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6
Q

Conducting Portion of Lung

A

Function - conduct air and condition the air (filter heat and humidify)
Structure - varying size, much thicker than lower
Outside the lung - is the nasal cavity nasal pharynx and trachea
in the lung - is the bronchi bronchioles and the last part is the terminal bronchioles

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7
Q

Terminal Bronchioles

A

The last bronchiloles in the conducting zone

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8
Q

Respiratory Portion of Lung

A

Function - Gas exchange
Structure - thin walls only location of alveoli
First part is the respiratory bronchioles

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9
Q

Respiratory Bronchioles

A

the first part of the respiratory zone in the lung

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10
Q

Blood Supply in the Lung (Two Systems)

A

Bronchiole Circulation - nutrient vessels bring nutrients to lung, to the tunica adventitia and muscle layer
Pulmonary circulation - function as respiratory vessels, like the pumonary artery brings deoxy blood

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11
Q

Location of the pumonary artery and vein near the lung

A

They do not travel together, the pulmonary artery - is adjacent to the airway
the pulmonary vein - is in the connective tissue
4 veins return blood to left atrium

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12
Q

Cartilage in the lung (and regional qualities)

A

It is hyaline cartalige
C Shaped in the trachea - lays open to the esophagus for food
Bronchi have plates of cartilage less supportive and more prone to colapse
bronchioles have no cartilage

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13
Q

Smooth Muscle In lungs

A

Regulate airway Diameter

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14
Q

Type of Fibers in the Lung

A

Collagen and Elastic for recoil

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15
Q

Emphysema

A

Breakdown of fibers causing decrease Surface area, is a COPD and enlarged airspace distal. It causes problems

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16
Q

The Pleura is What in the lungs

A

the serous membrane around the lungs that is mesothelium and connective tissue
it hangs in the pulmonary cavity
Pleura is continuous with hilum

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17
Q

The two pleuras seen around the lung and whats between

A

We see the visceral peura adhering to the lung surface
we see the pleural cavity crucial next for vaccum
then we see pariatel pleura which is on the edge of the pulmonary cavity

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18
Q

Nasal Cavity (Structure and Function)

A

Turbinates or Conchae are the bone shelf
Structure - bone shelf projections lined with pseudostratified epithelium. Well vascularized
also olfactory epithelium located at the roof
Function - increase surface area so resp epithelium can humidify and filter

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19
Q

Trachea layers that Exist (3)

A

Mucosa, Submucosa, and Adventitia Cartilage

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20
Q

Trachea Mucosa

A

Elastic rich, with lamina propria (loose connective tissue)
We see pseudostratified cells on the epithelium
There is no muscularis mucosa
Basement membrane looks glassy looking can see in fibrosis

21
Q

Tracheal Submucosa

A

location of glands along with basement membrane, mucous production

22
Q

Tracheal perichondrium

A

inner cell layer outer fibrous surrounds the cartilage

this is the adventitia layer that is also cartilage

23
Q

5 Cell Types of epithelium in the trachea

A

Ciliated, Mucous, Brush Cells, Small granule Cell, Basal Cells

24
Q

Ciliated Cells of the Trachea

A

Secretes pericilliary Fluid (water layer) that is critical. surround the cilia so mucous does not thicken around the cilia too much
cilia can also form mucociliary escalator - that moves mucous up and out of the body
each cell has so man cilia that sweep

25
Cystic Fibrosis
Increase mucus and a decrease in the pericilliary fluid | so the cilia can not move as well
26
Mucous Cells of trachea
Secretes mucous in to the cytoplasm. The mucous floats on the serous fluid Cilia moves this up and out
27
Mucociliary escalator
The movement of mucous coat out up the trachea
28
Brush Cells of trachea
Columnar Cells with blunt microvilli sensory receptor cells with synaptic contact on the basal side It is a receptor cell
29
Small Granule Cells of trachea
AKA enteroendocrine cells Contain secreotory ranules may function in reflexes
30
Basal Cell of trachea
Stem cell and will regenerate trachea epithelial
31
Metaplasia
The changing of epithelia from type to type in response to an irritant or toxin ex// ciliated pseudostrat to strat squamous will happen causing a caugh because of lack of cilia and smokers cough
32
Layers of the Bronchi
Mucosa - Same cells as the trachea, has the lamina propria and such more elastic fibers seen Muscularis mucosa - regulates diameter of airway Submucosa - location of glands Adventiatia/ cartilage - has the cartilage plates and decrease diameter
33
Epithelial Change in Bronchioles
Psuedostratified to simple columnar to Simple Cuboidal (not abrupt)
34
Layers in the Bronchioles
No Cartilage layer, no submucosal, thick smooth muscle layer, simple columnar to simple cuboidal
35
Cell Type Changes in the Bronchioles
The ciliated cells gradual decrease while club cells increase
36
Club Cells (Aka Clara Cells)
Take over epithelum from above. BEcome stem cell Secrete lipoportein to prevent adhesion to walls Detoxifies harmful compounds Non ciliated simple columnar
37
Alveoli Progression of Names
Alveoli - to alverolar ducts - to Alveolar Sacks
38
Alveoli Lining
Pneumocytes line the alveoli. this is the side of gas exchange
39
Alveolar Ducts
Only elastin and collagen fibers support with no smooth muscle
40
Alveolar Sacks
Just space surrounded by alveoli
41
Type I Pneumocytes
Gas Exchange happens V thin cell Squamous shaped with organelles wrapped aorund nucleus (so the cytoplasm is free for gas exchange) 95% of SA in alveolus
42
Type II pneumocytes
Septal Cells - Structure - rounded cells contains lamellar bodies Brown nucleus poke in to air space seen in corners occupy 5% of area Function - undergo mitosis to regenerate self and Type I also produce Surfactant to prevent collapse of alveoli
43
Interalveolar Septum Two Portions
Thick - pulmonary interstitium - we have collagen elastin, fibroblast, immune cells in these walls between sacks Thin - is the blood air barrier thin region one capillary wide only I pneumocytes
44
blood air barrier Cell layers
Endothelium of capillary. Basement membrane fuses t the Type I pneumocyte basement membrane with capillary. Four Components - Surfactant, alveolar epithelium, fused basement, endothelial
45
What connects the Type I and II pneumocytes
Desmosomes and occluding tight junctions
46
Alveolar Pores
Pores of Kohn **** Function - equalize pressure in alveoli enable colateral ventilation - if you block one oyu can shunt to another Allows for Dust Cell Migration
47
Defenses within the Lung System (3)
Nose and Trachea (done by Cilia) Mucociliary Ecalator - transport toward phayrnx Macrophages - called dust cells engulf and then migrate away or stay (depending on if system is overloaded)
48
What are the stem cells of each section
Trachea and Bronchi - the basal cell Bronchiole - club cell Alveolar - Type II pneumocyte